Abstract: The present invention relates to a method for assessing (analyzing) the risk of potential adverse effects for a human patient mediated by the administration of a CD19xCD3 bispecific antibody to said patient comprising determining the ratio of B cells to T cells of said patient, wherein a ratio of about 1:5 or lower is indicative for a risk of potential adverse effects for said patient or determining the total B cell count of said patient, wherein a total B cell count of less than about 50 B cells per microliter of peripheral blood is indicative for a risk of potential adverse effects for said patient.

Abstract: The present invention relates to the use of an anti-EpCAM antibody for the manufacture of a medicament for the treatment of metastatic breast cancer. The present invention further relates to a method of treating metastatic breast cancer comprising administering said anti-EpCAM antibody.

Abstract: The present invention provides means and methods for treating diffuse large B cell lymphoma (DLBCL). Specifically, a bispecific CD19×CD3 antibody which engages T cells via its CD3 binding portion and concomitantly binds to CD19 on the surface of in particular, lymphoma cells via its CD19 binding portion (i.e. a bispecific T cell engager, “BiTE”) is administered for use in the treatment of tumorous mass of lymophoreticular tissue and/or extranodal lymphoma caused by DLBCL in a patient.

Abstract: The present invention relates to a glucocorticoid (GC) for use in the amelioration, treatment or prophylaxis of neurological/psychiatric adverse events caused by a CD3 binding domain. Kits comprising a GC, a CD3 binding domain and instructions for use which indicate that the GC is to be employed for the treatment amelioration and/or prophylaxis of neurological adverse events caused by said CD3 binding domain, are also disclosed.

Abstract: A composite polypeptide, said composite polypeptide comprising a desired polypeptide and an expression enhancing domain (“EED”), said EED comprising first and second cysteine amino acid residues Cys1 and Cys2, respectively, Cys1 being located closer to the N-terminus of the composite polypeptide molecule than Cys2, wherein Cys1 and Cys2 are separated by a polypeptide linker, said linker—being free of cysteine and proline;—defining a length sufficient to allow Cys1 and Cys2 to engage in an intramolecular disulfide bond with one another; and—having a flexible polypeptide conformation essentially free of secondary polypeptide structure in aqueous solution, wherein at least one of Cys1 and Cys2 is derivatized with a derivatization moiety.

Abstract: The present invention relates to the use of an anti-EpCAM antibody for the manufacture of a medicament for the treatment of metastatic breast cancer. The present invention further relates to a method of treating metastatic breast cancer comprising administering said anti-EpCAM antibody.

Abstract: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by these methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by these methods.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to the use of an anti-EpCAM antibody for the manufacture of a medicament for the treatment of metastatic breast cancer. The present invention further relates to a method of treating metastatic breast cancer comprising administering said anti-EpCAM antibody.

Abstract: The present invention provides dual-fuel burners for the oxidation of liquid and of gaseous fuel with air. A dual-fuel burner is provided with an atomizer nozzle which generates a divergent spray cone of liquid fuel, and with an annular atomizer lip as an impact member for the liquid fuel spray cone. The dual-fuel burner has a primary channel for a first air stream through the spray cone and the inside of the atomizer lip, and a secondary channel for a second air stream over the outside of the atomizer lip with a common, coaxial mouth at an atomizer edge thereof. A channel for the gaseous fuel leads into the inside of the atomizer lip between the primary and secondary channels and discharges into one or both of the primary and secondary channels upstream of the atomizer edge.

Abstract: The curvature of an edge such as the trailing edge of a turbine blade having a specular reflection surface is inspected by illuminating the surface area to be measured with a laser beam and sensing the reflected laser light. The laser beam intensity across the cross-section of the laser beam is varied by a radiation intensity matrix located between the laser beam generator and the edge to be sensed or measured, whereby local radiation intensity variations are provided in the form of illuminating laser beam segments (A, B, C, . . . ) having different intensities. The beam reflected segments (A', B', C', . . . ) have a reflection angle that is equal to the incidence angle of the respective illuminating laser beam segments (A, B, C, . . . ). This fact is used for the correlation (A, A'; B, B'; C, C', . . . ). The reflected beam segments (A', B', C', . . . ) are scanned in a line-by-line fashion whereby the radiation intensity values varying along the curvature are measured.

Abstract: A vibration damper for rotor housings includes a rubber-elastic damping band (6) that encircles the outer circumference of the rotor housing (4) in a contour fitting manner. A clamping band (7) encircles the damping band (6) and secures the damping band to the housing (4). The clamping band is made of a material having a different modulus of elasticity than the material of the rotor housing, which achieves a detuning of the vibrational system including the rotor housing and the vibration damper as components. Such a detuning reduces the vibrational tendency of the rotor housing. Frictional rubbing between the damping band and the housing surface, and between the damping band and the clamping band effectively damps or dissipates the energy of any vibration that does occur.

Abstract: A change-over arrangement for an integrated turboramjet engine has a guide ring which can be displaced in the axial direction and an annular cone which can be displaced against the guide ring. In the turbo-operation, the annular cone is in its front position and the guide ring is in its rear position closing off a ram air inlet duct, and in the ramjet operation, the annular cone, in its rear position, closes off the turbo-inlet duct, and the guide ring opens up the ram air inlet duct. As a result, a low-loss introduction of the air current can take place into the turbo-inlet duct or into the ram air inlet duct, without, at the same time, requiring disadvantageous enlargements of the diameter of the outer casing of the engine.

Abstract: A heat exchanger having a tube matrix formed by a plurality of heat exchange tubes in which a trelliswork consisting of flexible carrier strips is wound on the tubes such that the tubes serve as crossbars of the trelliswork. The trelliswork is supported at its opposite ends to the frame of the heat exchanger via stay bars to provide support against shock forces and to absorb gravitational and flow forces on the tubes.

Abstract: A propeller blade of fiber-reinforced plastic with a combined erosion, icing and lightning protection system has a metal shroud fitted to its leading edge, the shroud enclosing a cavity and accommodating a heating conductor at its interior. A ground line of the heating conductor is connected to ground and serves as a lightning conductor.

Abstract: Rotor blades have feet engaged in axial grooves in a rotor disc and foot plates on the blades form with the surface of the rotor disc, axially and circumferentially extending intermediate spaces. Between sections of the blades and the rotor disc, overlaps of structural parts are developed at the intermediate spaces, by which the blades are fixed axially in the grooves in one direction. The overlaps of the structural parts can be formed between profiled or ground contours surfaces of the blade feet and profiled or broached contours surfaces of the rotor disc.

Abstract: An axial blade wheel of a gas or steam-driven turbine comprising blades having substantially laminar boundary layer flow up to a point of maximum velocity on the upper surface of the blade, the upper surface of the blade being provided in a region downstream of the point of maximum velocity where the fluid flow velocity decreases with a spoiler edge of saw tooth profile which extends substantially over the entire blade length.

Abstract: A non-contacting sealing arrangement for sealing two counter-rotating shafts with the aid of a housing having a tire-casing-like shape which surrounds at least one centrifugal disk connected for rotation in unison with one rotatable shaft and laterally surrounded by the casing-like part with a narrow gap; the casing-like part is arranged eccentrically to the axis of the shaft on which the centrifugal disk is mounted in order to thus assure a return feed for the liquid sealing medium, such as oil, to bearing places. The invention enables alternate pressure loads and is particularly suited in applications between at least two bearing chambers of aircraft propulsion units.

Abstract: Method and apparatus for manufacturing planar fiber webs from reinforcing fibers which are oriented in their passage through a hydrodynamic orientation section and deposited on a filter surface. In the process, the rotating orientation section produces a laminar flow pattern causing the reinforcing fibers in the slurry to be oriented. The filter surface is rotated, as is the orientation section, to hasten the extraction of the slurry liquid by filtration, to improve the degree of orientation of the fibers, and to fix the oriented fiber cake on the filter area. Extraction of the slurry liquid by filtration eliminates the need for washing or rewashing.