Abstract: The present invention relates to the use of a monophosphate ester of a phthalein compound as a substrate for Tartrate-Resistant Acid Phosphotase (TRAP). The substrate is used in assays for obtaining a measure of the amount of TRAP 5b in a sample of a subject, as an indication of the rate of bone resorption and therefore the likelihood of conditions such as osteoporosis. Also provided are kits comprising a monophosphate ester of a phthalein compound and optionally an antibody which binds total TRAP and methods.
Type:
Application
Filed:
April 8, 2009
Publication date:
May 5, 2011
Applicant:
MUNODIAGNOSTIC SYSTEMS LIMITED
Inventors:
Brian Houston, David Laurie, Jussi Halleen