Patents Assigned to Murdoch University
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Publication number: 20240141360Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: ApplicationFiled: May 1, 2023Publication date: May 2, 2024Applicants: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen WILTON, Merlin Christopher THOMAS, Carlos ROSADO, Raelene Jane PICKERING
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Publication number: 20230348977Abstract: The present disclosure relates generally to methods and protocols for the diagnosis, prognosis and stratification of patients with, or at risk of developing, sporadic amyotrophic lateral sclerosis (ALS). In particular, the methods and protocols of the present disclosure are based on determination of the presence and number of cytosine (C) adenine (A) dinucleotide repeats (CA dinucleotides) within the STMN2 gene.Type: ApplicationFiled: December 4, 2020Publication date: November 2, 2023Applicants: The University of Western Australia, Murdoch UniversityInventors: Frances THEUNISSEN, Patrick Anthony AKKARI, Loren FLYNN, Ryan ANDERTON
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Patent number: 11786611Abstract: An isolated or purified antisense oligonucleotide targeted to a nucleic acid molecule encoding vascular endothelial growth factor A (VEGF-A) pre-mRNA, wherein the antisense oligonucleotide has a nucleobase sequence selected from the list comprising SEQ ID NO: 1 to SEQ ID NO: 22 which has a modified backbone structure and sequences with at least 95% sequence identity to SEQ ID NO: 1-22 which have a modified backbone structure, and wherein the antisense oligonucleotide inhibits the expression of human VEGF-A.Type: GrantFiled: May 10, 2019Date of Patent: October 17, 2023Assignee: Murdoch UniversityInventor: Rakesh Veedu
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Patent number: 11674143Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: GrantFiled: September 7, 2022Date of Patent: June 13, 2023Assignees: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen Wilton, Merlin Christopher Thomas, Carlos Rosado, Raelene Jane Pickering
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Publication number: 20230015481Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: ApplicationFiled: September 7, 2022Publication date: January 19, 2023Applicants: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen WILTON, Merlin Christopher THOMAS, Carlos ROSADO, Raelene Jane PICKERING
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Patent number: 11459563Abstract: An isolated or purified antisense oligomer for modifying RNA cleavage and processing in the NEAT1 gene transcript or part thereof.Type: GrantFiled: February 5, 2018Date of Patent: October 4, 2022Assignees: The University of Western Australia, MURDOCH UNIVERSITYInventors: Stephen Donald Wilton, Sue Fletcher, Archa Fox, Ruohan Li
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Patent number: 11441148Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: GrantFiled: August 25, 2021Date of Patent: September 13, 2022Assignees: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen Wilton, Merlin Christopher Thomas, Carlos Rosado, Raelene Jane Pickering
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Patent number: 11236338Abstract: The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage disease type II (GSD-II) (also known as Pompe disease, glycogenosis II, acid maltase deficiency (AMD), acid alpha-glucosidase deficiency, and lysosomal alpha-glucosidase deficiency), and more specifically relates to inducing inclusion of exon 2 and thereby restoring levels of enzymatically active acid alpha-glucosidase (GAA) protein encoded by the GAA gene.Type: GrantFiled: September 5, 2014Date of Patent: February 1, 2022Assignees: SAREPTA THERAPEUTICS, INC., MURDOCH UNIVERSITYInventors: Stephen Donald Wilton, Sue Fletcher, Gunnar James Hanson, Richard Keith Bestwick
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Publication number: 20210388363Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: ApplicationFiled: August 25, 2021Publication date: December 16, 2021Applicants: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen WILTON, Merlin Christopher THOMAS, Carlos ROSADO, Raelene Jane PICKERING
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Patent number: 10457568Abstract: The invention discloses a method of removing dissolved elements from a liquid. The method comprises a first heating step for heating the liquid using a first heat source, a plurality of distillation steps for purifying the liquid heated by the first heating step, each of the plurality of distillation steps comprising at least one evaporation step and at least one condensation step, and a second heating step, using a second heat source to heat a plurality of flashing chambers, each generating a volume of vapor; wherein the vapor from at least one of the plurality of flashing chambers of the second heating step is introduced into at least one of the plurality of distillation steps.Type: GrantFiled: April 3, 2015Date of Patent: October 29, 2019Assignee: MURDOCH UNIVERSITY, National Centre of Excellence in Desalination AustraliaInventors: Bijan Rahimi, Hui Tong Chua, Alexander Christ
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Patent number: 10376536Abstract: An antisense oligomer capable of binding to a selected target on the ITGA4 gene transcript to modify pre-mRNA splicing in an ITGA4 gene transcript or part thereof.Type: GrantFiled: May 10, 2016Date of Patent: August 13, 2019Assignee: MURDOCH UNIVERSITYInventors: Stephen Donald Wilton, Sue Fletcher, May Aung-Htut
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Publication number: 20170029290Abstract: The invention discloses a method of removing dissolved elements from a liquid. The method comprises a first heating step for heating the liquid using a first heat source, a plurality of distillation steps for purifying the liquid heated by the first heating step, each of the plurality of distillation steps comprising at least one evaporation step and at least one condensation step, and a second heating step, using a second heat source to heat a plurality of flashing chambers, each generating a volume of vapor; wherein the vapor from at least one of the plurality of flashing chambers of the second heating step is introduced into at least one of the plurality of distillation steps.Type: ApplicationFiled: April 3, 2015Publication date: February 2, 2017Applicant: Murdoch UniversityInventors: Bijan RAHIMI, Hui Tong CHUA, Alexander CHRIST
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Publication number: 20170028349Abstract: An osmotic separation process for the extraction of a solvent from a first solution with low osmotic pressure, in a first compartment to a second solution with higher osmotic pressure in the second compartment. The first solution and the second solution are separated by a semi-permeable membrane.Type: ApplicationFiled: April 14, 2015Publication date: February 2, 2017Applicant: Murdoch UniversityInventors: Geatan BLANDIN, Pierre LECLECH
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Patent number: 8216472Abstract: The present invention relates to a method of treating a liquid to extract at least one of carbon, sulphur, nitrogen or phosphate from liquids such as waste water. Preferably, the invention is employed to remove nitrogen from waste water. In an alternate for the invention provides a wastewater treatment system.Type: GrantFiled: December 19, 2008Date of Patent: July 10, 2012Assignee: Murdoch UniversityInventors: Ralf Cord-Ruwisch, Leonie J. Hughes
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Patent number: 8182604Abstract: A method of forming a high strength cement in a permeable starting material, the method comprising the step of combining the starting material with effective amounts of (i) a urease producing micro-organism; (ii) urea; and (iii) calcium ions and wherein the effective amount of the urease producing organism provides a urea hydrolysis rate, under standard conditions, of 0.5-50 mM urea hydrolysed.min?1.Type: GrantFiled: December 20, 2005Date of Patent: May 22, 2012Assignees: Murdoch University, Calcite Technology Pty LtdInventors: Edward S. Kucharski, Ralf Cord-Ruwisch, Vicky Whiffin, Salwa M. Al-thawadi
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Publication number: 20110011800Abstract: The present invention relates to a method of treating a liquid to extract at least one of carbon, sulphur, nitrogen or phosphate from liquids such as waste water. Preferably, the invention is employed to remove nitrogen from waste water. In an alternate for the invention provides a wastewater treatment system.Type: ApplicationFiled: December 19, 2008Publication date: January 20, 2011Applicant: MURDOCH UNIVERSITYInventors: Ralf Cord-Ruwisch, Leonie Jane Hughes
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Publication number: 20100297178Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of animals caused by other Brachyspira species, including B. intermedia, B. alvinipulli, B. aalborgi, B. innocens, B. murdochii, and B. pilosicoli.Type: ApplicationFiled: March 19, 2007Publication date: November 25, 2010Applicant: MURDOCH UNIVERSITYInventors: David John Hampson, Matthew Bellgard, Tom La
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Publication number: 20090120877Abstract: The invention provides a process for producing a desalinated aqueous liquid. The process comprising passing a de-gassed aqueous liquid (115) through a reverse osmosis membrane (110). The process may additionally comprise the step of degassing an aqueous liquid (105) to produce the degassed aqueous liquid (115).Type: ApplicationFiled: May 24, 2006Publication date: May 14, 2009Applicant: Murdoch UniversityInventor: Richard Mark Pashley
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Publication number: 20080317806Abstract: A compound of Formula (A), wherein R1 is C1-C5 alkyl, C3-C6 branched alkyl, C4-C7 cycloalkyl, C8-C12 fused or bridged polycycloalkyl, or heterocyclic ring, where any of the preceding alkyl, cycloalkyl or heterocyclic ring groups may be singly or multiply substituted with X; R2 is H or R1; and X is halo, carbonyl carboxylic acid, carboxylic ester, carboxamide, substituted carboxamide, hydroxy, alkoxy, thioalkyl, sulphoxide, sulphone, sulphonamide, substituted sulphonamide, phenoxy, substituted phenoxy, phenyl, substituted phenyl, amino, substituted amino (including quaternary ammonium salts), N-oxide, imino, 5-7 membered heterocycle, or substituted heterocycle.Type: ApplicationFiled: April 11, 2006Publication date: December 25, 2008Applicant: Murdoch UniversityInventors: Wayne Morris Best, Colette Gloria Sims, Richard Christopher Andrew Thompson, Simon Andrew Reid, Anthony Armson, James Alexander Reynoldson
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Publication number: 20080193935Abstract: A method for detecting a repeat element in a target ruminant nucleic acid sequence, the method comprising the steps of: (a) contacting a nucleic acid probe capable of hybridizing with a nucleotide sequence flanking said element; and (b) detecting the complex formed between the probe and the target nucleic acid wherein the repeat elements are formed of repeating nucleotide sequences of at least (3) nucleotides.Type: ApplicationFiled: February 24, 2006Publication date: August 14, 2008Applicant: Murdoch UniversityInventors: Kylie Munyard, David Groth, Keith Gregg