Abstract: The present invention includes compositions and methods for the knockdown of one or more genes to a target cell in need of gene therapy by using an siRNA transgene that is integrated into a replication-competent, oncolytic adenovirus.
Type:
Application
Filed:
May 4, 2007
Publication date:
November 8, 2007
Applicants:
BAYLOR RESEARCH INSTITUTE, MUREX PHARMACEUTICALS, BAYLOR UNIVERSITY
Inventors:
Alex W. Tong, Yu An Zhang, John J. Nemunaitis, Yuqiao Shen, Po-hsun Chen, Shirley K. Samuel