Patents Assigned to Musculoskeletal Transplant Foundation
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Patent number: 11938245Abstract: Cartilage fibers and implants made therefrom are disclosed, with and without cartilage particles. Methods for making the cartilage fibers and the implants containing them are also disclosed. The implants may be pre-shaped, may be reshapable and, when implanted in a cartilage defect, the implants have good shape retention, little swelling, completely fill the cartilage defect and resist migration from the defect upon irrigation.Type: GrantFiled: March 31, 2021Date of Patent: March 26, 2024Assignee: Musculoskeletal Transplant FoundationInventors: Michael A. Nasert, Florence Stoffel, Paul R. Williams, Alex Callahan
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Patent number: 11925546Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: GrantFiled: December 3, 2020Date of Patent: March 12, 2024Assignee: Musculoskeletal Transplant FoundationInventors: Michael Locarno, Bryan Choi, Manh-Dan Ngo
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Patent number: 11806443Abstract: Cartilage fibers and implants made therefrom are disclosed, with and without cartilage particles. Methods for making the cartilage fibers and the implants containing them are also disclosed. The implants may be pre-shaped, may be reshapable and, when implanted in a cartilage defect, the implants have good shape retention, little swelling, completely fill the cartilage defect and resist migration from the defect upon irrigation.Type: GrantFiled: May 21, 2021Date of Patent: November 7, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Michael A. Nasert, Florence Stoffel, Paul R. Williams, Alex Callahan
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Patent number: 11786637Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: March 1, 2021Date of Patent: October 17, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 11779610Abstract: Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.Type: GrantFiled: November 29, 2021Date of Patent: October 10, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 11642216Abstract: Soft tissue repair grafts are provided for supporting, covering, and/or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and/or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.Type: GrantFiled: October 13, 2020Date of Patent: May 9, 2023Assignees: Musculoskeletal Transplant Foundation, The Methodist HospitalInventors: Aldona Jedrysiak Spiegel, Kai-Roy Wang
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Patent number: 11596517Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.Type: GrantFiled: October 10, 2019Date of Patent: March 7, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 11589895Abstract: A device for separating a sample of tissue in a controlled and precise manner and, more particularly, to produce a piece of tissue having a generally planar configuration and, optionally, additional desired characteristics, such as a predetermined maximum thickness, and selected tissue type. The device is adjustable to allow for different thicknesses and different operational speeds for application to different types of recovered tissue samples.Type: GrantFiled: August 18, 2020Date of Patent: February 28, 2023Assignee: Musculoskeletal Transplant FoundationInventors: German Eduardo Jurado Rivera, Moises Rivera-Alvarado, Samuel Arocho, Walter E. Diaz, Manuel A. Olivos Sanchez
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Patent number: 11524093Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: GrantFiled: December 22, 2020Date of Patent: December 13, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Patent number: 11375710Abstract: A tissue graft container is provided having an interior space and including a vent which allows fluid (liquid and vapor) to escape from the container during drying of the tissue graft. The vent may be one or more apertures, one or more elongated openings, or a combination thereof, through one or more components of the container. A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channels, and configured to removeably interconnect the first and second members in a closed configuration. The first and second pluralities of channels create a continuous interior space. The retainer further includes a vent, such as apertures, slits, etc., through one or both of the first and second retainers, for allowing moisture to escape from the retainer during the drying of a tissue graft contained within the continuous interior space of the retainer.Type: GrantFiled: June 17, 2020Date of Patent: July 5, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling
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Patent number: 11191788Abstract: An acellular soft tissue-derived matrix suitable for use as a medical graft or implant may comprise, for example, a delipidated, decellularized adipose tissue matrix. The delipidated, decellularized adipose tissue matrix is substantially free of substances that pose a significant risk of causing an immunogenic response in a patient receiving the matrix. Methods for producing the delipidated, decellularized adipose tissue matrix include the steps of delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting delipidated, decellularized adipose tissue matrix contains a proportion of Type IV collagen which is greater than the proportion of Type IV collagen contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating.Type: GrantFiled: February 5, 2020Date of Patent: December 7, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 11185346Abstract: A cutting device is provided having multiple evenly-spaced cutting blades and which is useful for producing tissue forms comprising membranous tissue fragments which are relatively uniformly sized and shaped. The present invention also relates to methods for using the cutter device to quickly and efficiently produce such tissue forms which are useful as grafts and can be flowable and easily passable through a luer-slip tip syringe or needle.Type: GrantFiled: January 10, 2018Date of Patent: November 30, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Todd J. Nilsen
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Patent number: 11052175Abstract: Cartilage fibers and implants made therefrom are disclosed, with and without cartilage particles. Methods for making the cartilage fibers and the implants containing them are also disclosed. The implants may be pre-shaped and may be reshapable and provide good shape retention and little swelling when placed into a cartilage defect.Type: GrantFiled: August 15, 2016Date of Patent: July 6, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Michael A. Nasert, Florence Stoffel, Paul R. Williams, Alex Callahan
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10945831Abstract: A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.Type: GrantFiled: June 3, 2016Date of Patent: March 16, 2021Assignees: Musculoskeletal Transplant Foundation, The Methodist HospitalInventors: Antonio M. Bunce, Todd J. Nilsen, Evangelia Chnari, Aldona J. Spiegel, Michael Locarno, Gregory P. Adams
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Patent number: 10912864Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: GrantFiled: May 31, 2019Date of Patent: February 9, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Patent number: 10881501Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: GrantFiled: January 10, 2019Date of Patent: January 5, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Michael Locarno, Bryan Choi, Manh-Dan Ngo
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Patent number: 10828141Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer. An implant which may include a hydrated tissue graft may be positioned within the packaging assembly. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, even if the implant is not immersed in fluid within the packaging assembly, thereby avoiding need for rehydrating steps that are required for dehydrated and/or cryopreserved implants prior to or during surgery. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: GrantFiled: February 5, 2020Date of Patent: November 10, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Patent number: D954993Type: GrantFiled: June 17, 2020Date of Patent: June 14, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling
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Patent number: D1001311Type: GrantFiled: January 5, 2022Date of Patent: October 10, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling