Abstract: The instant disclosure provides a composition comprising a capsule and a fill formulation for lipophilic salts of PDE5 inhibitors. Embodiments of the fill formulation contain a liquid, lipid vehicle in which the active ingredient is dissolved and present at relatively high amounts.
Type:
Application
Filed:
October 23, 2018
Publication date:
November 5, 2020
Applicant:
MW Encap Limited
Inventors:
Peter John Scammells, Christopher John Hamilton Porter, Hassan Benameur, Hywel David Williams, Leigh Ford
Abstract: The disclosure relates generally to ionic salts, particularly low-melting ionic salts such as ionic liquids, of poorly-water soluble drugs. The disclosure further relates to methods of preparing the ionic salts of poorly-water soluble drugs, lipid formulations comprising them and their use in drug delivery.
Type:
Application
Filed:
August 1, 2014
Publication date:
June 2, 2016
Applicant:
MW ENCAP LIMITED
Inventors:
Chris Porter, Peter Scammells, Hywel Williams, Yasemin Sahbaz
Abstract: The present invention relates to processes for the manufacture of suspensions comprising one or more water soluble or water insoluble pharmaceutical or nutraceutical active ingredients with a particle size in the range of from 0.01 to 10 micron. More specifically, suspensions prepared by this process can be used to formulate pharmaceutical compositions, especially in liquid fill capsules.
Abstract: Hard shell capsules filled with a pharmaceutical medicament and at least one modifier, selected to prevent abuse of the medicament are described. The modifier may have a high melting point, and therefore melt at a temperature too high to inject or be insoluble in liquid, having a density less than 1, to prevent “spiking” of drinks. The modifier may also be a waxy substance which cannot be crushed, a viscosity modifier, a dye or a taste modifier.
Abstract: An active principle delivery device (1) comprising an inner capsule (4) within an outer capsule (2), the inner and outer capsules (4,2) containing the same active principle (5,3), with at least the outer capsule (2) being a hard capsule and the active principle (3,5) in at least one of the capsules (2,4), comprising a fluid. Also provided is a method of fabricating such a delivery device (1), as well as a method of controlling the pharmaco-kinetic profile of an active principle.
Type:
Grant
Filed:
July 19, 2001
Date of Patent:
November 4, 2008
Assignee:
MW Encap Limited
Inventors:
Massoud Bakhshaee, William John Bowtle, Alyn Brandon McNaughton