Abstract: The present invention provides a composition comprising a co-culture of at least two distinct bacterial families, having differing growth and/or proliferative conditions. In some embodiments, the composition comprises a plurality of bacterial genera with high similarity to microbial flora.
Type:
Grant
Filed:
July 6, 2021
Date of Patent:
June 20, 2023
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, David Daboush, Rachel Diamant
Abstract: The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
Type:
Grant
Filed:
September 24, 2020
Date of Patent:
June 20, 2023
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, Rachel Diamant, David Daboush
Abstract: The present invention provides a composition comprising a co-culture of at least two distinct bacterial families, having differing growth and/or proliferative conditions. In some embodiments, the composition comprises a plurality of bacterial genera with high similarity to microbial flora.
Type:
Grant
Filed:
May 25, 2017
Date of Patent:
September 21, 2021
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, David Daboush, Rachel Diamant
Abstract: The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
Type:
Grant
Filed:
September 24, 2020
Date of Patent:
May 11, 2021
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, Rachel Diamant, David Daboush
Abstract: The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
Type:
Grant
Filed:
May 9, 2016
Date of Patent:
October 6, 2020
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, Rachel Diamant, David Daboush
Abstract: Compositions comprising 10% to 50% (w/w) of at least one probiotic bacteria in the form of biofilm, and lipophilic carriers are provided. Further, process for making such compositions and methods of use are provided.
Type:
Grant
Filed:
March 28, 2019
Date of Patent:
July 14, 2020
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Daboush, Stephanie Cohen, Dorit Rozner