Abstract: Methods for producing a bio-based material from a waste material containing gypsum via mycoremediation. Under controlled environmental conditions, the mycological conversion of waste containing gypsum diverts waste streams from landfills and creating pathways of reuse as new mycelium-based materials. Mycoremediation provides an ability to sustainably produce resilient sources of many products and allows for economically and environmentally viable alternatives to many synthetic and carbon-rich materials.