Patents Assigned to Mycologics, Inc.
  • Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
    Publication number: 20070172503
    Abstract: Embodiments of the present invention illustrate methods of treating and preventing infection due to a pathogen such as a fungal pathogen. In particular, the present invention relates to compositions and methods for vaccinations against or treatment for a fungal organism in a non-immunocompromised or immunocompromised subject.
    Type: Application
    Filed: December 13, 2006
    Publication date: July 26, 2007
    Applicant: MycoLogics,Inc.
    Inventors: Claude Selitrennikoff, Tamara Miller
  • Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
    Patent number: 6743598
    Abstract: The present invention provides methods for simultaneously assessing microbial phosphoglucose isomerase, ketol-isomerase and glucosamine-6-phosphate acetyltransferase activities, by measuring the production of Coenzyme A (CoA). The present invention finds use in the isolation of new classes of antifungal drugs, wherein the compounds have the ability to inhibit fungal glucose utilization.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: June 1, 2004
    Assignees: MycoLogics, Inc., Toyama Chemical Co., Ltd.
    Inventors: Claude P. Selitrennikoff, Mitsunori Nakata
  • Methods for the identification of antimicrobial compounds
    Patent number: 6730495
    Abstract: The present invention relates to methods to assay 2-amino-2-deoxy-D-glucose-6-phosphate ketol-isomerase activity. The present invention also relates to methods for drug screening to identify compounds having antimicrobial activity, wherein the compounds have the ability to inhibit the enzymatic activity of a microbial ketol-isomerase. In other embodiments, methods are provided for the identification of compounds that selectively inhibit microbial ketol-isomerase activity compared to the ketol-isomerase activity of the subject being treated for an infection.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: May 4, 2004
    Assignee: Mycologics, Inc.
    Inventors: Claude P. Selitrennikoff, Mitsunori Nakata
  • Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
    Publication number: 20030194758
    Abstract: The present invention provides methods for simultaneously assessing microbial phosphoglucose isomerase, ketol-isomerase and glucosamine-6-phosphate acetyltransferase activities, by measuring the production of Coenzyme A (CoA). The present invention finds use in the isolation of new classes of antifungal drugs, wherein the compounds have the ability to inhibit fungal glucose utilization.
    Type: Application
    Filed: August 10, 2001
    Publication date: October 16, 2003
    Applicant: MycoLogics, Inc.
    Inventors: Claude P. Selitrennikoff, Mitsunori Nakata
  • Cyclic peroxides as novel antifungal agents
    Patent number: 6521661
    Abstract: The novel compositions and methods of the subject invention can be used in antifugal applications. The antifugal agents of the subject invention can be used in the treatment of an animal or human having a fugal infection. In a further embodiment the compounds can be used to treat plant fugal infections, disinfect surfaces, and prevent spoilage of organic compositions such as food and cosmetics.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 18, 2003
    Assignees: Harbor Branch Oceanographic Institution, Inc., Mycologics, Inc.
    Inventors: Ying Chen, Katherine Chilson, Keith Brian Killday, Dedra Harmody, Peter J. McCarthy, Shirley A. Pomponi, Rebecca Schimoler, Claude Selitrennikoff, Amy E. Wright
  • Fungicidal saponin, CAY-1, and isolation thereof from Capsium species fruit
    Patent number: 6310091
    Abstract: A novel antifungal compound, “CAY-1”, was isolated from the dried fruit of Capsicum frutescens (cayenne pepper), purified to homogeneity, and characterized as a novel sterol glycoside (a saponin) with a molecular mass of 1243.35 Da. CAY-1 demonstrates antifungal activity against a large variety of fungal organisms associated with diseases in plants, animals and humans including, but not limited to, Aspergillus flavus, A. fumigatus, A. parasiticus, A. niger, Pneumocystis carnii and Candida albicans, but has minimal toxic effects on mammalian cells.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: October 30, 2001
    Assignees: The United States of America as represented by the Secretary of Agriculture, Mycologics, Inc.
    Inventors: Anthony J. De Lucca, II, John M. Bland, Craig B. Vigo, Claude P. Selitrennikoff
  • Comparative assay method and device
    Patent number: 4652520
    Abstract: A method and device for performing comparative assay of binding and bindable substances such as antibodies and antigens. The device includes a circulation conduit for continuously conveying a carrier fluid between a support zone therein and a detection zone therein. A competitive binding substance is fixed in the support zone and is capable of competitively binding a test substance and an analytical detection substance such that changes in concentration of the test substance in the carrier fluid responsively cause changes of concentration of analytical detection substance in the carrier fluid. Each of the analytical detection substance (antigen-fluorochrome, for example) and the test substance (antigen, for example) are bound to the binding substance (monoclonal antibody, for example) in proportion to the concentration of the test substance in the carrier fluid.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: March 24, 1987
    Assignee: Immuno-Mycologics, Inc.
    Inventor: David S. Bauman