Abstract: A device, for helping a wheeled vehicle to negotiate an obstacle, includes a stationary framework, a substantially horizontal frame movable between a high position and a low position in which the frame rests on the framework, and an assembly for vertically translating the frame, the assembly is supported by the framework and supports the frame, the drive assembly includes a pair of shears with X-shaped articulated arms, each arm having an end hinged to the frame and an end hinged to the framework, by translation at one end, a drive actuator for driving the frame between the low and high positions. A plate is supported by the frame and, when the frame is in the high position, translatably movable horizontally relative to the frame, so as to come into contact with a vertex of the obstacle, the plate being flush with the neighboring ground when in the low position.

Abstract: A device for helping a wheeled vehicle to negotiate an obstacle includes: a frame; a plate having two ends, a first end being movable between a high position and a low position in which the plate constitutes an access ramp; a flap constituting a front surface of the device when the plate is in the high position and provides ramp access when the plate is in the low position; and a drive assembly for driving the first end between the low position and the high position. The drive assembly includes an actuator and a carriage movable along a longitudinal axis. The device further includes a pair of side railings rigidly connected to the carriage, each having a control profile controlling the position of the plate, and a pair of resilient bars arranged between the flap and side railings.

Abstract: An assistance device (1) to allow a wheeled vehicle to overcome an obstacle, comprising a frame, (2), an upper plate (4), a lower plate (3) with lateral rims (41), a flap (5) and a locking member (71; 72). The upper plate (4) is supported on the lateral rims (41). By moving in translation between a deployed position and a storage position, the lower plate (3) mechanically determines the height position of the upper plate (4) by sliding on the lateral rims (41). The flap (5) pivots relative to the upper plate (4) between a substantially vertical rest position and a deployed position resting on the lower plate (3). The flap (5) forms a junction between the lower plate (3) and the upper plate (4). The locking member (71; 72) is supported by the lateral rims (41) and locks the flap (5) in the storage position of the lower plate (3) and releases the flap (5) when the lower plate (3) leaves the storage position of same.

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract: Assembly for giving access to at least one wheelchair (1) comprising a frame (2) supported by wheels (5, 7) and provided with a seat (3), the assembly comprising a docking station (100) having a structure (201) delimiting at least one docking point designed to receive the chair such that, when the chair is in the docking point, the chair rests on its wheels and the seat of the chair is disposed so as to be usable by a user who wishes to sit down.