Patents Assigned to Myelos Corporation
-
Publication number: 20120172305Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: ApplicationFiled: October 28, 2011Publication date: July 5, 2012Applicant: MYELOS CORPORATIONInventors: DAVID E. WRIGHT, D. ELLIOT PARKS
-
Publication number: 20110306558Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: ApplicationFiled: February 7, 2011Publication date: December 15, 2011Applicant: MYELOS CORPORATIONInventors: John S. O'BRIEN, Yasuo KISHIMOTO
-
Patent number: 8063016Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: GrantFiled: March 31, 2010Date of Patent: November 22, 2011Assignee: Myelos CorporationInventors: David E. Wright, D. Elliot Parks
-
Publication number: 20110195908Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: ApplicationFiled: April 13, 2011Publication date: August 11, 2011Applicant: Myelos CorporationInventors: John S. O'Brien, Yasuo Kishimoto
-
Publication number: 20110190213Abstract: The invention provides methods of treatment using retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native IL-3 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: ApplicationFiled: March 16, 2010Publication date: August 4, 2011Applicant: MYELOS CORPORATIONInventors: David E. WRIGHT, D. Elliot PARKS
-
Publication number: 20100286072Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: ApplicationFiled: March 31, 2010Publication date: November 11, 2010Applicant: MYELOS CORPORATIONInventors: David E. WRIGHT, D. Elliot PARKS
-
Publication number: 20100260734Abstract: A method for stimulating prosaposin receptor activity in a cell by transfecting the cell with a DNA or RNA molecule encoding prosaposin or a prosaposin receptor agonist. The DNA or RNA molecule is administered either in vivo or used to transfect neural cells or neural stem cells ex vivo followed by reintroduction of the cells into an individual.Type: ApplicationFiled: April 15, 2010Publication date: October 14, 2010Applicant: MYELOS CORPORATIONInventors: John S. O'BRIEN, D. Elliot PARKS
-
Patent number: 7754688Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: GrantFiled: October 5, 2006Date of Patent: July 13, 2010Assignee: Myelos CorporationInventors: David E. Wright, D. Elliott Parks
-
Patent number: 7754690Abstract: The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.Type: GrantFiled: August 9, 2006Date of Patent: July 13, 2010Assignee: Myelos CorporationInventors: David E. Wright, D. Elliott Parks
-
Patent number: 7524818Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: GrantFiled: June 18, 2003Date of Patent: April 28, 2009Assignee: Myelos CorporationInventors: John S. O'Brien, Yasuo Kishimoto
-
Patent number: 7135461Abstract: Retro-inverso peptides derived from interleukin-6 (IL-6) having between 17 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-6 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.Type: GrantFiled: June 16, 2000Date of Patent: November 14, 2006Assignee: Myelos CorporationInventors: David E. Wright, D. Elliott Parks
-
Patent number: 7115571Abstract: Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-3 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.Type: GrantFiled: June 16, 2000Date of Patent: October 3, 2006Assignee: Myelos CorporationInventors: David E. Wright, D. Elliott Parks
-
Patent number: 7109168Abstract: Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native LIF and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.Type: GrantFiled: June 16, 2000Date of Patent: September 19, 2006Assignee: Myelos CorporationInventors: David E. Wright, D. Elliott Parks
-
Patent number: 6590074Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: GrantFiled: November 26, 1996Date of Patent: July 8, 2003Assignee: Myelos CorporationInventors: John S. O'Brien, Yasuo Kishimoto
-
Patent number: 6559124Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: GrantFiled: May 12, 1998Date of Patent: May 6, 2003Assignee: Myelos CorporationInventors: John S. O'Brien, Yasuo Kishimoto
-
Patent number: 6458357Abstract: Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C. The saposin C-derived peptides (prosaptides) induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and pain management. The retro-inverso peptides are significantly more resistant to metabolic degradation than the corresponding non-inverted peptides.Type: GrantFiled: September 3, 1998Date of Patent: October 1, 2002Assignee: Myelos CorporationInventors: Michael T. White, John S. O'Brien, David E. Wright
-
Publication number: 20020077275Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination exvivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: ApplicationFiled: January 22, 2001Publication date: June 20, 2002Applicant: Myelos Corporation.Inventors: John S. O'Brien, Yasuo Kishimoto
-
Patent number: 5571787Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.Type: GrantFiled: July 30, 1993Date of Patent: November 5, 1996Assignee: Myelos CorporationInventors: John S. O'Brien, Yasuo Kishimoto