Patents Assigned to Mylan Laboratories Limited
  • Process for the production of etravirine
    Patent number: 8653266
    Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: February 18, 2014
    Assignee: Mylan Laboratories Limited
    Inventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
  • Process for the preparation of oxcarbazepine
    Patent number: 8530647
    Abstract: The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of ?-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: September 10, 2013
    Assignee: Mylan Laboratories Limited
    Inventors: Nageswara Rao Karusala, Uma Sankara Sastry Tummalapally, Appi Reddy Talatala, Debashish Datta
  • Crystalline forms of Nelfinavir mesylate
    Patent number: 8367832
    Abstract: The present invention provides novel crystalline forms of Nelfinavir mesylate, Form-A, Form-B, Form-C, Form-D and the process for their preparation without the use of any special equipment such as a spray drier, avoiding the use of highly flammable solvents such as ethers. The crystalline form can be tailored with the selection of the ante solvent and appropriate conditions for the process.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: February 5, 2013
    Assignee: Mylan Laboratories Limited
    Inventors: Chava Satyanarayana, Vasireddy Umamaheswara-Rao, Vellanki Siva Ram Prasad, Balusu Rajababu
  • Carvedilol phosphate sesquihydrate
    Patent number: 8344159
    Abstract: The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: January 1, 2013
    Assignee: Mylan Laboratories Limited
    Inventors: Seeta Ramanjaneyulu Gorantla, Mohan Bandari, Nageshwara Rao Karusala, Sankara Sastry Tummalapalli Uma