Patents Assigned to Mylan Laboratories
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Publication number: 20160280642Abstract: The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-Imorpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R, S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the componnd (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one with hydroxy protecting group b) hydrolyzing the obtained componnd c) condensing with a chiral auxiliary d) reacting with an protected imine componnd e) converting to alkyl ester f) cyclizing and g) deprotecting to obtain Ezetimibe.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Applicant: Mylan Laboratories LimitedInventors: Mofazzal Husain, Srikanth G.S.C., Swapna Thorpunuri, Debashish Datta
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Patent number: 9388440Abstract: The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R,S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the compound (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one with hydroxy protecting group b) hydrolyzing the obtained compound c) condensing with a chiral auxiliary d) reacting with an protected imine compound e) converting to alkyl ester f) cyclizing and g) deprotecting to obtain Ezetimibe.Type: GrantFiled: March 30, 2010Date of Patent: July 12, 2016Assignee: Mylan Laboratories LimitedInventors: Mofazzal Husain, Sarat Chandra Srikanth Gorantla, Swapna Thorpunuri, Datta Debashish
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Patent number: 9273333Abstract: The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors. wherein X is hydrogen or hydroxy protecting group and R1 is carboxyl protecting group.Type: GrantFiled: May 28, 2014Date of Patent: March 1, 2016Assignee: Mylan Laboratories LTDInventors: Michiel Christian Alexander Van Vliet, Willem Robert Klaas Schoevaart, Madhuresh Kumar Sethi, Sanjay Mahajan, Bhairaiah Mara
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Patent number: 9187409Abstract: The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides novel intermediates used in the preparation of Aliskiren.Type: GrantFiled: October 19, 2011Date of Patent: November 17, 2015Assignee: Mylan Laboratories LimitedInventors: Rama Shankar, Vadali Lakshmana Rao, Palla Vijay Kumar, Saidugari Swamy, Dasari Srinivasa Rao, Srinivasa Rao Potla, Mittapelly Nagaraju, Jaldu Ravikanth, Vijaya Krishna Ravi, Seshadri Rao Manukonda, Dandala Ramesh
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Publication number: 20150299200Abstract: The present invention relates to a process for preparing Linagliptin by purifying the intermediate compounds converting the purified intermediates into Linagliptin. The present invention also relates to the preparation of an amorphous Linagliptin.Type: ApplicationFiled: December 16, 2013Publication date: October 22, 2015Applicant: MYLAN LABORATORIES LTDInventors: Bhausaheb CHAVHAN, Jebaraj RATHINAPANDIAN, Shiva Kumar CHANDUPTLA, Nagaraji GHANDA
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Patent number: 9145365Abstract: The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast.Type: GrantFiled: May 8, 2014Date of Patent: September 29, 2015Assignee: Mylan Laboratories Ltd.Inventors: Priyesh Vijaykar, Dattatrey Kokane, Sushant Gharat, Dhananjay Shinde, Manojkumar Bindu, Vinayak Gore
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Patent number: 9090537Abstract: The present invention relates to an improved process for the preparation of pure compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts.Type: GrantFiled: February 15, 2013Date of Patent: July 28, 2015Assignee: Mylan Laboratories LimitedInventors: Shankar Rama, Seshadri Rao Manukonda, Srinivasa Rao Dasari, Ramesh Dandala, Lakshmana Rao Vadali
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Patent number: 8993786Abstract: The main object of the present invention relates to a novel crystalline form of Fosemprenavir Calcium designated as Form A. Another object of the present invention relates to a process for the preparation of Crystalline Form A of Fosemprenavir Calcium. Yet another object of the present invention relates to crystalline Forma A of Fosemprenavir Calcium characterized by a PXRD diffraction having reflections at about 3.1±0.2, 4.4±0.2, 5.0±0.2, 6.3±0.2, 7.4±0.2, 8.0±0.2, 2?.Type: GrantFiled: February 9, 2012Date of Patent: March 31, 2015Assignee: Mylan Laboratories Ltd.Inventors: Ramakoteswara Rao Jetti, Neelima Bhagavatula, Asha Rani Gorantla
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Patent number: 8974824Abstract: The present invention discloses stable, solid oral pharmaceutical composition comprising Lanthanum carbonate having more than 6 molecules of water per molecule of lanthanum carbonate and pharmaceutically acceptable carriers or diluents, wherein said carrier or diluent excludes monosaccharide/s or disaccharide/s, such that the composition has comparable in-vitro dissolution profile similar to that of FOSRENOL®. Also disclosed is a wet granulation process for making the same.Type: GrantFiled: March 24, 2009Date of Patent: March 10, 2015Assignee: Mylan Laboratories Ltd.Inventors: Nagaraj Amminabavi, Indu Bhushan, Satish Kumar Jain, Subhash Gore, Gnanadeva Chalapathy Gudipati, Balakrishnan Chinnu, Subramanian Iyer, Manoj P Kumar, Rajesh S Gupta
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Publication number: 20150011793Abstract: The present invention relates to an improved process for the preparation of pure compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts.Type: ApplicationFiled: February 15, 2013Publication date: January 8, 2015Applicant: MYLAN LABORATORIES LTDInventors: Shankar Rama, Seshadri Rao Manukonda, Srinivasa Rao Dasari
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Publication number: 20140299176Abstract: Apparatus for the industrial wiring and final testing of photovoltaic concentrator modules, consisting of a module frame, a lens disc, a sensor carrier disc and an electrical line routing arrangement, comprising the following features: a) a laser contact-making device for the contactless connection of connecting lines between the individual sensors and of connecting elements and of collective contact plates, wherein the line routing arrangement on the sensor carrier disc as basic structure has in each case 5 CPV sensors connected in parallel, and these parallel circuits are connected in series, b) a device for testing electrical properties, wherein a specific voltage is applied to CPV sensors themselves, and the light emitted by them via the lenses is detected and assessed, c) a device for testing tightness of finished concentrator modules, wherein compressed air is applied to the modules in the interior and the emission of compressed air is checked.Type: ApplicationFiled: December 7, 2012Publication date: October 9, 2014Applicant: Mylan Laboratories LTD.Inventor: Eckart Gerster
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Publication number: 20140283486Abstract: The present invention relates to polymorphic forms of Febuxostat and processes for the preparation of polymorphic forms of Febuxostat.Type: ApplicationFiled: May 15, 2014Publication date: September 25, 2014Applicant: MYLAN LABORATORIES LTDInventors: Ramakoteswara Rao JETTI, Balakrishna Reddy Bhogala, Satish Beeravelli
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Patent number: 8841467Abstract: The present invention relates to a novel process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol of formula I by reacting a compound of formula VII with the compound of formula R2-OH in the presence of haloginating agent to obtain a compound of formula VI and treating a compound of formula VI with dehaloginating agent to obtain a compound of formula V by reducing a compound of formula V, followed by cylization to obtain compound of formula IV and separating the enantiomer and diastereomers from compound of formula IV to yield a compound of formula I. Compound of formula I is useful as an intermediate in the preparation of protease inhibitors, in particular broad spectrum HIV protease inhibitors, the present invention also relates to process for the preparation of Darunavir from (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol.Type: GrantFiled: July 14, 2011Date of Patent: September 23, 2014Assignee: Mylan Laboratories LimitedInventors: Siva Rama Prasad Vellenki, Arabinda Sahu, Nitin Ashok Shimpi, Anil Ponnuru, Satish Babu Kothari
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Publication number: 20140275551Abstract: The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast.Type: ApplicationFiled: May 8, 2014Publication date: September 18, 2014Applicant: MYLAN LABORATORIES LTD.Inventors: Priyesh VIJAYKAR, Dattatrey Kokane, Sushant Gharat, Dhananjay Shinde, Manojkumar Bindu, Vinayak Gore
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Publication number: 20140275242Abstract: The presently disclosed subject matter is directed to a granule, wherein the granule has an active agent and a wax dispersed therein, and the granule exhibits excellent friability when compressed to form a pharmaceutical composition. The subject matter disclosed herein is also directed to methods of preparing the granules and the pharmaceutical compositions comprising the granules. The compositions and methods disclosed provide granules and pharmaceutical compositions for immediate release of the active agent and do not substantially prolong the release of the active agent from the granule.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Mylan Laboratories, Inc.Inventors: Chaoju Xiao, Boyong Li
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Patent number: 8759515Abstract: The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.Type: GrantFiled: March 11, 2011Date of Patent: June 24, 2014Assignee: Mylan Laboratories LimitedInventors: Debashish Datta, Siva Rama Prasad Vellanki, Arabinda Sahu, Raja Babu Balusu, Mastan Rao Ravi, Hari Babu Nandipati, Shankar Rama, Lakshmana Rao Vadali, Srikanth Sarat Chandra Gorantla, Srinivasa Rao Dasari, Nagaraju Mittapelly
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Publication number: 20140135504Abstract: The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form ? and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form ? with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.Type: ApplicationFiled: January 23, 2014Publication date: May 15, 2014Applicant: MYLAN LABORATORIES LIMITEDInventors: Ramakoteswara Rao Jetti, Chetan Kanaiyalal Raval, Aggi Ramireddy Bommareddy, Debashish Datta
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Patent number: 8686161Abstract: The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form ? and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form ? with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.Type: GrantFiled: June 22, 2009Date of Patent: April 1, 2014Assignee: Mylan Laboratories LimitedInventors: Ramakoteswara Rao Jetti, Chetan Kanaiyalal Raval, Aggi Ramireddy Bommareddy, Debashish Datta
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Patent number: 8653266Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.Type: GrantFiled: April 26, 2012Date of Patent: February 18, 2014Assignee: Mylan Laboratories LimitedInventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
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Publication number: 20130317236Abstract: The main object of the present invention relates to novel crystalline form of Fosamprenavir Calcium designated as Form A. Another object of the present invention relates to a process for the preparation of Crystalline Form A of Fosamprenavir Calcium. Yet another object of the present invention relates to crystalline Form A of Fosamprenavir Calcium characterized by an PXRD diffraction having reflections at about 3.1±0.2, 4.4±0.2, 5.0±0.2, 6.3±0.2, 7.4±0.2, 8.0±0.2, 28.Type: ApplicationFiled: February 9, 2012Publication date: November 28, 2013Applicant: MYLAN LABORATORIES LTD.Inventors: Ramakoteswara Rao Jetti, Neelima Bhagavatula, Asha Rani Gorantla