Abstract: The present application provides pharmaceutical compositions comprising as the active medicinal ingredient nebivolol, a nebivolol analog or a pharmaceutically acceptable acid addition salt thereof and a wetting agent. The invention also relates to methods of preparing and using said compositions.
Type:
Grant
Filed:
May 5, 2015
Date of Patent:
November 6, 2018
Assignee:
Mylan Pharmaceuticals ULC
Inventors:
Mostafa Akbarieh, Fazal M. Mohideen, Shetal Shah
Abstract: The invention relates to a process for the solid oral pharmaceutical formulation of a pharmaceutically active ingredient such as levetiracetam, comprising a wet granulation of the pharmaceutically active ingredient and simultaneous fluid bed drying such that, as the pharmaceutical blend granulates it is simultaneously dried thus preventing it from becoming a paste. The invention therein thus provides a novel formulation preparation process characterized by a “combined” Granulation and Fluid Bed Drying process step.