Patents Assigned to Mylan Technologies, Inc.
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Patent number: 9492401Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.Type: GrantFiled: December 27, 2010Date of Patent: November 15, 2016Assignee: Mylan Technologies, Inc.Inventors: Kristin Jackson, Kenneth James Miller, II
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Patent number: 9358373Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: GrantFiled: May 15, 2014Date of Patent: June 7, 2016Assignee: Mylan Technologies IncInventor: Kenneth J. Miller, II
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Publication number: 20160136107Abstract: Disclosed is a transdermal delivery device comprising a backing layer, a release liner, and an adhesive layer between the backing layer and the release liner, the adhesive layer comprising an active agent solubilized in an adhesive matrix, the adhesive matrix comprising a mixture of biocompatible polymers, wherein the active agent is soluble in at least one of the biocompatible polymers.Type: ApplicationFiled: June 20, 2014Publication date: May 19, 2016Applicant: Mylan Technologies, Inc.Inventors: Abhijit Deshmukh, Akhilesh Dixit, Rajesh Kumar Bijay, Prasanna Kumar
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Patent number: 9226902Abstract: A solid dispersion transdermal drug delivery system comprising a therapeutic agent in a stable amorphous form and a combination polymeric stabilizing and dispersing agent having a hydrogen bond-forming functional group, and a method of manufacturing these systems is provided. The weight ratio of the combination polymeric stabilizing and dispersing agent to the therapeutic agent is also disclosed.Type: GrantFiled: May 29, 2009Date of Patent: January 5, 2016Assignee: Mylan Technologies Inc.Inventor: Jiashang Tang
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Publication number: 20150246006Abstract: Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.Type: ApplicationFiled: April 30, 2015Publication date: September 3, 2015Applicant: Mylan Technologies, Inc.Inventors: Kristin Jackson, Kenneth J. Miller, II, Pavan Bhat
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Patent number: 9017301Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured highly crosslinked silicone. The present invention also refers to a method of preparing a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured silicone.Type: GrantFiled: September 4, 2007Date of Patent: April 28, 2015Assignee: Mylan Technologies, Inc.Inventor: Jiansheng Tang
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Patent number: 8846093Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: GrantFiled: May 4, 2011Date of Patent: September 30, 2014Assignee: Mylan Technologies, Inc.Inventors: Sharad K. Govil, Ludwig J. Weimann
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Publication number: 20140249492Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: MYLAN TECHNOLOGIES, INC.Inventor: Kenneth J. Miller, II
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Publication number: 20140243379Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: MYLAN TECHNOLOGIES, INC.Inventors: Sharad K. Govil, Ludwig J. Weimann
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Patent number: 8802136Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: GrantFiled: June 13, 2013Date of Patent: August 12, 2014Assignee: Mylan Technologies, Inc.Inventor: Kenneth J. Miller, II
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Patent number: 8614274Abstract: A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.Type: GrantFiled: January 11, 2011Date of Patent: December 24, 2013Assignee: Mylan Technologies Inc.Inventors: Kristin Jackson, Kenneth James Miller, II
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Patent number: 8524272Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: GrantFiled: August 15, 2003Date of Patent: September 3, 2013Assignee: Mylan Technologies, Inc.Inventor: Kenneth J. Miller, II
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Publication number: 20130018078Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: ApplicationFiled: September 20, 2012Publication date: January 17, 2013Applicant: MYLAN TECHNOLOGIES INC.Inventor: Mylan Technologies Inc.
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Publication number: 20110151003Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.Type: ApplicationFiled: December 27, 2010Publication date: June 23, 2011Applicant: Mylan Technologies, Inc.Inventors: Kristin JACKSON, Kenneth James Miller, II
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Patent number: 7955677Abstract: Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.Type: GrantFiled: December 7, 2005Date of Patent: June 7, 2011Assignee: Mylan Technologies, Inc.Inventors: Brad L. Barnett, Martin Fletcher, Kenneth J. Miller, II
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Publication number: 20110123613Abstract: Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.Type: ApplicationFiled: December 23, 2010Publication date: May 26, 2011Applicant: MYLAN TECHNOLOGIES INC.Inventors: Pavan Bhat, Sarat C. Chattaraj, Andrew A. Shaw
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Publication number: 20110106022Abstract: A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.Type: ApplicationFiled: January 11, 2011Publication date: May 5, 2011Applicant: Mylan Technologies Inc.Inventors: Kristin Jackson, Kenneth James Miller, II
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Patent number: 7888422Abstract: A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.Type: GrantFiled: November 8, 2006Date of Patent: February 15, 2011Assignee: Mylan Technologies Inc.Inventors: Kristin Jackson, Kenneth James Miller, II
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Publication number: 20100086582Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of reestablishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.Type: ApplicationFiled: October 1, 2009Publication date: April 8, 2010Applicant: MYLAN TECHNOLOGIES, INC.Inventors: Jiansheng Tang, Joseph M. Deverich, Kenneth J. Miller, II, Russell D. Beste
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Patent number: 7638140Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: GrantFiled: December 8, 2003Date of Patent: December 29, 2009Assignee: Mylan Technologies, Inc.Inventors: Sharad K. Govil, Ludwig J. Weimann