Patents Assigned to Myogen, Inc.
  • Compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
    Patent number: 7638519
    Abstract: The present invention provides certain compounds, pharmaceutical formulations thereof, and methods for the treatment of conditions mediated by 5-HT2 receptors. These compounds provide for modulation of the signals mediated by 5-HT2 receptors, specifically those receptors in the cardiovascular system. Thus, these compounds may be used alone or in conjunction with other drugs to treat cardiovascular diseases such as, but not limited to, muscle atrophy, cardiac hypertrophy, heart failure, and primary pulmonary hypertension.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: December 29, 2009
    Assignee: Myogen, Inc.
    Inventors: Erik Bush, Larry Melvin
  • Model cell systems for screening of anti-hypertrophic therapeutics
    Publication number: 20030186289
    Abstract: The present invention identifies the rat muscle cell line H9C2 as a suitable platform for drug screening of potential anti-hypertrophic agents. These cells exhibit gene expression patterns that are characteristic of hypertrophic cells, thus permitting a variety of in vitro screens on candidate drugs to be conducted.
    Type: Application
    Filed: January 21, 2003
    Publication date: October 2, 2003
    Applicant: Myogen, Inc.
    Inventors: Erik Bush, Nikos Pagratis