Patents Assigned to Myoscience, Inc.
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Patent number: 8461108Abstract: Systems and methods of tissue remodeling or altering a surface of a skin of a patient are provided. A method includes increasing myostatin activity in a target tissue. Methods can include increasing myostatin activity in a target tissue in addition to various tissue remodeling techniques, including cryogenic cooling of target tissue for tissue remodeling.Type: GrantFiled: March 9, 2009Date of Patent: June 11, 2013Assignee: MyoScience, Inc.Inventors: Michael Hsu, Lisa Elkins
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Patent number: 8409185Abstract: The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion.Type: GrantFiled: February 16, 2007Date of Patent: April 2, 2013Assignee: Myoscience, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Patent number: 8298216Abstract: Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.Type: GrantFiled: November 14, 2008Date of Patent: October 30, 2012Assignee: MyoScience, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Publication number: 20120265187Abstract: A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.Type: ApplicationFiled: December 13, 2011Publication date: October 18, 2012Applicant: MyoScience, Inc.Inventors: Francis R. Palmer, III, Michael Hsu, Kristine Tatsutani
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Publication number: 20120089211Abstract: A method for cryogenically treating tissue comprises piercing the skin, inserting a sheath into tissue, and passing a cryoprobe through the sheath into the tissue. The cryoprobe cools a first region of the tissue, is repositioned in the sheath, and then cools a second region of the tissue.Type: ApplicationFiled: April 8, 2011Publication date: April 12, 2012Applicant: Myoscience, Inc.Inventors: Robert M. Curtis, Phillip Olsen
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Publication number: 20120065629Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: ApplicationFiled: July 7, 2011Publication date: March 15, 2012Applicant: MyoScience Inc.Inventors: Lisa Elkins, Ronald Williams
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Patent number: 7998137Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: GrantFiled: April 12, 2010Date of Patent: August 16, 2011Assignee: MyoScience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Publication number: 20110144631Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: ApplicationFiled: November 17, 2010Publication date: June 16, 2011Applicant: Myoscience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Patent number: 7862558Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: GrantFiled: March 6, 2009Date of Patent: January 4, 2011Assignee: MyoScience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Patent number: 7850683Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: GrantFiled: June 28, 2007Date of Patent: December 14, 2010Assignee: Myoscience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Publication number: 20100198207Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: ApplicationFiled: April 12, 2010Publication date: August 5, 2010Applicant: MyoScience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Patent number: 7713266Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: GrantFiled: December 5, 2005Date of Patent: May 11, 2010Assignee: Myoscience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Publication number: 20090248001Abstract: Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.Type: ApplicationFiled: November 14, 2008Publication date: October 1, 2009Applicant: MyoScience, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Publication number: 20090226424Abstract: Systems and methods of tissue remodeling or altering a surface of a skin of a patient are provided. A method includes increasing myostatin activity in a target tissue. Methods can include increasing myostatin activity in a target tissue in addition to various tissue remodeling techniques, including cryogenic cooling of target tissue for tissue remodeling.Type: ApplicationFiled: March 9, 2009Publication date: September 10, 2009Applicant: Myoscience, Inc.Inventor: Michael Hsu
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Publication number: 20090171334Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: ApplicationFiled: March 6, 2009Publication date: July 2, 2009Applicant: MyoScience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Publication number: 20080200910Abstract: The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion.Type: ApplicationFiled: February 16, 2007Publication date: August 21, 2008Applicant: MYOSCIENCE, INC.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Publication number: 20080183164Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.Type: ApplicationFiled: June 28, 2007Publication date: July 31, 2008Applicant: Myoscience, Inc.Inventors: Lisa Elkins, Ronald Williams
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Publication number: 20080154254Abstract: Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.Type: ApplicationFiled: December 21, 2006Publication date: June 26, 2008Applicant: MYOSCIENCE, INC.Inventors: Keith Burger, Ronald Williams, Lisa Elkins
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Patent number: D683733Type: GrantFiled: June 18, 2012Date of Patent: June 4, 2013Assignee: MyoScience, Inc.Inventors: Jonathan Mendoza, Jeffrey Servaites