Abstract: An ultrasound imaging system and method includes acquiring first 4D ultrasound data of a first partial volume for a first period of time that is longer than an estimated cardiac period and acquiring second 4D ultrasound data of a second partial volume for a second period of time that is longer than the estimated cardiac period. The system and method includes combining the first 4D ultrasound data with the second 4D ultrasound data to generate 4D ultrasound data of a region-of-interest. The system and method also includes generating and displaying an image based on the 4D ultrasound data.