Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
Type:
Grant
Filed:
February 15, 2017
Date of Patent:
September 3, 2019
Assignee:
Myriad Genetics, Inc.
Inventors:
Victor Abkevich, Kirsten Timms, Alexander Gutin, Julia Reid
Abstract: Disclosed are screening methods and sequences related thereto. Disclosed are methods for detecting mutations in the MYH gene of an individual. Also disclosed are methods of genotyping and methods of predicting for an individual the likelihood of developing certain cancers, such as colorectal cancer.
Type:
Grant
Filed:
October 1, 2009
Date of Patent:
April 18, 2017
Assignee:
Myriad Genetics, Inc.
Inventors:
Julian R. Sampson, Jeremy Peter Cheadle
Abstract: Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.
Type:
Grant
Filed:
August 30, 2011
Date of Patent:
March 28, 2017
Assignee:
Myriad Genetics, Inc.
Inventors:
Steven Stone, Alexander Gutin, Susanne Wagner, Julia Reid
Abstract: A method predicts the residual risk of recurrence after a taxane-free chemotherapy, and the benefit from inclusion of taxane in a chemotherapy regimen in a patient suffering from or at risk of developing recurrent breast cancer. From determination of expression levels of the genes UBE2C, KIF20A, PTGER3, OSBPL1A, CYP27A1, IGKC, in a tumor sample a prognostic score is determined by mathematically combining the expression level values. The prognostic score is compared to thresholds, classifying the patient in three outcome groups. The expression levels of three genes STC1, PCSK6, S100P in the tumor sample are determined, and the expression level values for STC1, PCSK6 and S100P are mathematically combined to yield a predictive combined score, whereas a high predictive combined score generally indicates an increased likelihood of benefit from inclusion of taxane in a chemotherapy regimen in a patient classified to poor and/or intermediate outcome group.
Type:
Application
Filed:
February 11, 2015
Publication date:
December 1, 2016
Applicant:
Myriad Genetics, Inc.
Inventors:
Jan Christoph BRASE, Marcus SCHMIDT, Ralf KRONENWETT, Karin FISCH, Karsten WEBER
Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
Type:
Grant
Filed:
June 18, 2014
Date of Patent:
July 12, 2016
Assignee:
Myriad Genetics, Inc.
Inventors:
Victor Abkevich, Alexander Gutin, Kirsten Timms, Jerry Lanchbury
Abstract: The present invention relates to DEP2, as well as other proteins, and their uses in connection with the treatment of major depression or related disorders.
Type:
Grant
Filed:
August 24, 2006
Date of Patent:
January 13, 2015
Assignees:
AbbVie Inc., Myriad Genetics, Inc.
Inventors:
David A. Katz, Jeremy C. Packer, Anahita Bhathena, Christopher Neff, Victor Abkevich, Donna Shattuck, Srikanth Jammulapati
Abstract: A computer-implemented method is discussed that includes identifying, by a computer server system, stored electronic data that represents genetic sequencing for one or more genes for individuals in a population of patients who have submitted to genetic sequencing; generating, for each of multiple individuals and from the stored electronic data, probability data for the individuals and probability or weighting data, or both, for relatives of the individuals, the probability data representing likelihoods that a particular person corresponding to the probability data carries a deleterious mutation in a particular gene; and generating a score for a genetic variant, wherein the score is a function of probability or weighting data, or both, for the individuals and for relatives of the individuals, and the score represent a composite probability that a certain variant is a deleterious or benign variant.
Type:
Application
Filed:
March 13, 2014
Publication date:
September 18, 2014
Applicant:
Myriad Genetics, Inc.
Inventors:
Dmitry Pruss, Brian Morris, Karla Bowles, Julie M. Eggington, Benjamin B. Roa, Alexander Gutin, Elisha Hughes
Abstract: The invention generally relates to a molecular classification of disease and particularly to methods and compositions for determining BRCA deficiency.
Type:
Application
Filed:
March 28, 2013
Publication date:
January 23, 2014
Applicant:
MYRIAD GENETICS, INC.
Inventors:
Kirsten Timms, Darl Flake, Jennifer Potter, Jerry Lanchbury
Abstract: Large deletions have been identified in the PMS2 gene in patients. The large deletions predispose the patients to Lynch syndrome associated cancers.
Abstract: Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.
Type:
Application
Filed:
August 30, 2011
Publication date:
November 14, 2013
Applicant:
MYRIAD GENETICS, INC.
Inventors:
Steven Stone, Alexander Gutin, Susanne Wagner, Julia Reid
Abstract: Large deletions have been identified in the PMS2 gene in patients. The large deletions predispose the patients to Lynch syndrome associated cancers. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.
Type:
Application
Filed:
March 22, 2013
Publication date:
September 26, 2013
Applicant:
Myriad Genetics, Inc.
Inventors:
Karla Bowles, Benoit Leclair, Saradha Rajamani, Jeffrey T. Trost, Jack W. Landon, Benjamin B. Roa