Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH; Y represents —C3-9alkyl-, —C1-5alkyl-NR12—C1-5alkyl-, —C1-6alkyl-NH—CO— or —CO—NH—C1-6alkyl-; X1 represents —O—; X2 represents a direct bond, —NR11—C1-2alkyl-, —NR11—CH2—, —C1-2alkyl-, —O—C1-2alkyl, —O— or —O—CH2—; R1 represents hydrogen or halo; R2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C1-4alkyloxycarbonyl-, Het16-carbonyl- or Ar5; R3 represents hydrogen, hydroxy, C1-4alkyloxy-, Ar4—C1-4alkyloxy or R3 represents C1-4alkyloxy substituted with one or where possible two or more substituents selected from C1-4alkyloxy- or Het2-; R10 represents hydrogen; R11 represents hydrogen, C1-4alkyl- or C1-4alkyl-oxy-carbonyl-; R12 represents Het14-C1-4alkyl, in particular morpholinyl-C1-4alkyl; Het2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C1-4alkyl-, preferab

Abstract: A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.

Abstract: A flywheel energy storage assembly and a method for dissipating energy stored in a flywheel assembly is provided. The flywheel energy storage assembly includes a flywheel rotatably disposed in a flywheel housing, a fluid source, a braking actuator in fluid communication with the fluid source and an interior of the flywheel housing, a sensor, and a controller in communication with the sensor and the braking actuator. In response to a stimulus detected by the sensor, the controller directs the braking actuator to facilitate fluid communication between the fluid source and the interior of the flywheel housing to dissipate energy stored in the flywheel energy storage assembly.

Abstract: A system and method for registering three-dimensional images with two-dimensional intra-operative images includes segmenting (24) a tubular structured organ in a three-dimensional image of the organ, and projecting (26) the three-dimensional image of the organ into two-dimensional space to provide a projected image. A medical instrument depicted in a two-dimensional image of the medical instrument is segmented (28). A similarity score is computed between the projected image and a shape of the medical instrument depicted in the two-dimensional image to determine a best match. The projected image is registered (30) to the two-dimensional image based on the best match.

Abstract: Described are means and methods for removing a proteolytic cleavage site from a protein, the method comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, and allowing translation of mRNA produced from the pre-mRNA.

Abstract: An ultrasound system (10) which is capable of biplane imaging is able to display, store and export independent image frames of only the reference image or only the variable orientation image, or the standard display of both images. The system is also able to sweep through a range of image plane orientations and to automatically acquire an image in each orientation over the range of plane orientations. The system is preferably operable in the biplane tilt mode, the biplane rotate mode, or the biplane elevation tilt mode.

Abstract: An electrode configured to provide electrical contact with a subject's skin and includes a conductive layer and a gel layer. The conductive layer spreads current and transmits electrical signals to and/or receives electrical signals from the subject's skin and has a first conductive surface through which electrical signals are transmitted to and/or received from the subject's skin. The first conductive surface is on a side of the conductive layer that faces toward the subject's skin if the electrode is installed on the subject. The gel layer is formed on the same side of the conductive layer as the first conductive surface. The gel layer has a first interface surface that directly contacts the subject's skin if the electrode is installed on the subject, and to conduct electrical signals between the subject's skin and the first conductive surface. The first interface surface has a surface area larger than that of the first conductive surface.

Abstract: A displacement sensor module 1 for mounting on a telescopic-type damper 30, a damper/detector assembly including such a displacement sensor module and a telescopic-type damper, and a household appliance including such a damper/detector assembly is provided. The displacement sensor module 1 includes at least one coil element 4, an electronic detection unit 8 connected to the at least one coil element 4 and adapted to detect an impedance change of the at least one coil element, and a coil housing 2 for receiving and additionally or alternatively a coil support 6 for supporting the at least one coil element 4 and for supporting the electronic detection unit 8. The displacement sensor module 1 is adapted to be mounted on a telescopic-type damper 30, wherein in particular the housing 2 or support 6 is adapted to fit over a portion of a pre-assembled damper 30.

Abstract: A method is presented for selecting and isolating nucleic acids capable of conferring tolerance or resistance to environmental stress conditions in plants or yeast. Furthermore, nucleic acids, the proteins they encode and their use for the production of plants or yeast with enhanced environmental stress resistance is disclosed.

Abstract: A vehicle driveline and a method for transferring energy from a flywheel is provided. The vehicle driveline includes a power source, a clutch drivingly engaged with the power source, a transmission drivingly engaged with the clutch, a power transmission device drivingly engaged with one of the power source, the clutch, and the transmission, a controller in communication with the power transmission device, and a flywheel drivingly engaged with the power transmission device. The power transmission device facilitates a transfer of energy from the flywheel to one of the clutch and the transmission. The power transmission device also facilitates a transfer of energy from one of the power source, the clutch, and the transmission to the flywheel. The controller directs the transfer of energy to and from the flywheel.

Abstract: The invention is directed to a method for ultrasonic imaging, in which two-dimensional images (10, 11) are acquired, one of which is aligned with a longitudinal direction of an interventional object (e.g. a needle) (13) to be moved towards a target area (7) within a subject of examination and the other one is intersecting the longitudinal direction of the interventional object (13) and automatically positioned dependent on the automatically determined position and orientation of the interventional object (13). Further, the invention is directed to an ultrasonic imaging device (1) adapted to conduct such a method.

Abstract: Elastic pad with a concrete element on which rails of a railway rest, whereby the elastic pad includes a fixing mat and an elastic mat, the fixing mat being provided with standing filaments that are at least partially embedded in the concrete element.

Abstract: A boiler for heating a liquid, in particular water, and having at least one module in turn having a cylindrical conduit closed at the ends by two caps and fitted through with an electric resistor, which defines an annular channel between itself and the conduit, and is fitted in fluidtight manner to each cap and to the inner surface of the conduit by a respective single seal; the conduit having a tubular inlet fitting and tubular outlet fitting, which are located close to the opposite axial ends of the annular channel, are independent of the caps, and have respective channels extending radially with respect to and communicating with the annular channel; the tubular inlet and outlet fittings being complementary in shape.

Abstract: Signal processing devices normally filter the signal to reduce noise. Any filtering is likely to eliminate useful components of the signal too. A device for and method of signal processing is disclosed, wherein intrinsically clean signal cycles are selected for reproduction so that the processed signal retains components of all frequencies. A system that uses the disclosed device and the method for processing periodic physiological signals is also disclosed.

Abstract: A multi-function defibrillator having an improved mode selection switch (200). When the switch is rotated to select the desired mode of operation, such as defibrillation, cardio-version, pacing, or monitoring, the positioning of those modes related to the Off position (205) is based on the time-criticality of the corresponding therapy. The most time-critical therapy is located closest to the Off position, and the least time-critical therapy is located furthest away from the Off position.

Abstract: Pharmacogenetic methods for determining a predicting responsiveness to antifolate therapy for subjects that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted responsiveness to antifolate therapy by correlating the parameter values with predefined responsiveness values associated with ranges of parameter values. Parameters values that are decisive for responsiveness to antifolate therapy may include polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD1) gene as well as in three genes involved in the adenosine release pathway, the presence or absence of Rheumatoid factors, gender, pre- or postmenopausal status and/or smoking status.

Abstract: Elements are added to a light emitting device to reduce the stress within the light emitting device caused by thermal cycling. Alternatively, or additionally, materials are selected for forming contacts within a light emitting device based on their coefficient of thermal expansion and their relative cost, copper alloys being less expensive than gold, and providing a lower coefficient of thermal expansion than copper. Elements of the light emitting device may also be structured to distribute the stress during thermal cycling.

Abstract: The invention relates to a luminescent converter (101) that may for example be used as a luminescent solar concentrator (LSC) in a solar power generator (100). The luminescent converter (101) comprises magic-sized clusters (110), MSCs, of a luminescent material. Preferably, said luminescent material comprises a compound of two elements from groups IV and VI, for example PbSe. The MSCs (110) may be embedded in a transparent light guiding element (120) or be embedded in a thin film on a surface thereof.

Abstract: A radiation force balance calibrator (100) for calibrating a high intensity focused ultrasound transducer (106), the radiation force balance calibrator comprising: a balance frame (130); a force sensor (138) for measuring force, wherein the force sensor is attached to the balance frame; a balance (124) with first (132) and second ends (134), wherein the first end is attached to a pivot (128) for enabling the balance to pivot relative to the balance frame, wherein the second end is adapted for exerting force onto the force sensor; an oil target phantom (116) connected to the balance for absorbing ultrasound radiation (112, 114) from the high intensity focused ultrasound transducer, wherein the absorption of ultrasonic radiation causes a reduction in the force exerted by the balance on the force sensor; and wherein the radiation force balance calibrator is constructed of non-magnetic materials.

Abstract: A system and method control an amount of power delivered by a power converter (220) to a solid state lighting load (240). It is determined whether a dimmer (204) is present between a voltage source (201) and the power converter (220) based on a rectified input voltage from the voltage source. When the dimmer is determined to be present, an operating point of the power converter is adjusted to increase the amount of power delivered by the power converter to the solid state lighting load by a compensation amount, so that the increased amount of power is equal to an amount of power delivered by the power converter when the dimmer is not present.