Abstract: The invention pertains to the use of uridine and/or an equivalent thereof and n3-PUFA in the manufacture of a product for restoring or improving bladder function in a subject, in particular in a patient suffering from spinal cord injury.
Abstract: The invention relates to a nutritional composition comprising (a) at least 18 en % of proteinaceous matter, said proteinaceous matter comprising whey; (b) at least 12 wt % of leucine, based on total proteinaceous matter; and (c) a lipid fraction comprising at least a ?-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid for improving the muscle function in a mammal, for improving daily activity, for improving physical performance, for providing a better prognosis in terms of extended life-expectancy, for improving compliance to an anti-cancer therapy or for improving a quality of life.
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
April 24, 2018
Assignee:
N. V. Nutricia
Inventors:
Klaske Van Norren, Adrianus Lambertus Bertholdus Van Helvoort, Joyce Faber, Robert Johan Joseph Hageman, Arjan Paul Vos
Abstract: The present invention relates to a two-step emulsification process for preparing a lipid and protein component-containing composition comprising large lipid globules, preferably coated with polar lipids, and to the compositions obtained thereby. Optionally, the lipid and protein component-containing composition is spray-dried. The obtained compositions are for feeding infants and young children.
Type:
Application
Filed:
March 11, 2016
Publication date:
April 5, 2018
Applicant:
N. V. NUTRICIA
Inventors:
Koen Cornelis VAN DIJKE, Jewe SCHRÖDER, Memet Ali USTUNEL, Daniël Georg Reinhold HALSEMA, Raoul Charles Johan MOONEN
Abstract: The present invention relates to a process for the production of a powdered composition from a liquid composition comprising fat, protein or both, to the powdered composition obtained thereby and products containing said powdered composition.
Type:
Grant
Filed:
March 30, 2012
Date of Patent:
February 20, 2018
Assignee:
N.V. NUTRICIA
Inventors:
Joep van den Brenk, Johan Michiel Adriaan Bosman, Geertje Katrien Huijs
Abstract: The invention relates to the use of specific protein and/or peptide fractions having a high aspartate content for regulating plasma glucose concentrations and increasing insulin sensitivity in a mammal. The invention relates to a complete food fortified with aspartate equivalents as well as a supplement rich in aspartate equivalents that is given simultaneously with or even minutes up to an hour prior to the consumption of a meal comprising glucose. The nutritional or pharmaceutical composition contains at least one protein having a high aspartate content, preferably of soy or dairy origin, which is further enriched with aspartate equivalents from another protein and/or free aspartate equivalents. The protein fraction comprises glutamate equivalents in a weight ratio of aspartate equivalents to glutamate equivalents (asp:glu) between 0.41:1 and 5:1.
Abstract: An infant and/or toddler nutrition comprising non-viable Bifidobacterium breve and a non-digestible oligosaccharide and its use are disclosed.
Type:
Grant
Filed:
August 25, 2016
Date of Patent:
February 6, 2018
Assignee:
N.V. NUTRICIA
Inventors:
Sander Hougee, Adrianus Johannes Maria Vriesema, Johan Garssen, Jan Knol
Abstract: The invention relates to the use of one or more nucleotides for improving the heat stability of an aqueous micellar casein composition comprising 6 to 20 g per 100 ml of micellar casein, and having a pH of about 6 to 8. The invention also relates to heat-treated liquid nutritional compositions comprising 6 to 20 g, preferably 9-20 g, of protein per 100 ml of the composition and having a pH of about 6 to 8, in which all or a major part of said protein comprises micellar casein, further comprising one or more nucleotides.
Type:
Grant
Filed:
July 16, 2012
Date of Patent:
January 23, 2018
Assignee:
N.V. Nutricia
Inventors:
Esther Jacqueline Petra De Kort, Marcel Minor
Abstract: A food or supplement for pregnant women comprising water soluble, non-digestible saccharides is described. The composition is used to improve the flora and/or immune system of the pregnant women, to improve the immune system of the infant and to improve the intestinal flora of the infant after birth.
Type:
Grant
Filed:
January 9, 2015
Date of Patent:
January 23, 2018
Assignee:
N. V. Nutricia
Inventors:
Christopher Beermann, Jan Knol, Martine Sandra Alles, Bernd Stahl, Günther Boehm
Abstract: The present invention relates to a combination of a leucine source and at least one unsaturated fatty acid source for prophylactic or therapeutic treatment of hypercalcaemia. The invention further relates to a combination of a leucine source and at least one unsaturated fatty acid source for reducing or avoiding a reduction in bone mineral density in a subject or for in vivo regulating of the blood plasma calcium homeostasis.
Type:
Grant
Filed:
July 25, 2014
Date of Patent:
January 16, 2018
Assignee:
N.V. Nutricia
Inventors:
Klaske Van Norren, Joyce Faber, Adrianus Lambertus Bertholdus Van Helvoort, Robert Johan Joseph Hageman
Abstract: The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B 12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.
Type:
Grant
Filed:
October 31, 2016
Date of Patent:
December 19, 2017
Assignee:
N.V. Nutricia
Inventors:
Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
Abstract: The invention relates to a nutritional composition comprising dietary fiber, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, for use in the treatment of a negative emotion or introvert behavior. The invention further relates to a combination of dietary fiber, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, and optionally one or more other components, for use in the treatment of a negative emotion or introvert behavior.
Abstract: Disclosed is a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination synergistically improves the immune system by stimulating the Th1 response, and/or decreasing the Th2 response, improving the vaccination response, improving the resistance against infections and/or decreasing allergy.
Type:
Application
Filed:
January 13, 2017
Publication date:
October 19, 2017
Applicant:
N.V. Nutricia
Inventors:
Belinda POTAPPEL-VAN 'T LAND, Leon Matthieu Johannes KNIPPELS, Alma Jildou NAUTA, Johan GARSSEN
Abstract: We describe a composition comprising a non-digestible oligosaccharide for the treatment, prevention or alleviation of a trichothecene mycotoxin exposure associated condition. The non-digestible oligosaccharide may comprise a galactooligosaccharide and/or fructooligosaccharide. The non-digestible oligosaccharide may comprise a short chain galacto-oligosaccharide (scGOS) and/or short chain fructooligosaccharide (scFOS). The trichothecene mycotoxin exposure associated condition may be associated with exposure to deoxynivalenol.
Type:
Grant
Filed:
May 17, 2013
Date of Patent:
October 10, 2017
Assignee:
N.V. Nutricia
Inventors:
Johan Garssen, Hermiena Christina Schoterman, Johanna Fink-Gremmels, Saskia Braber
Abstract: The present invention relates to a method for improving behaviour in a human subject, comprising administering a nutritional composition comprising 5-50 wt % vegetable lipids based on dry weight of the composition to the subject, the nutritional composition comprising lipid globules having (i) a volume-weighted mode diameter above 1.0 micrometer and/or (ii) a diameter of 2 to 12 micrometer in an amount of at least 45 volume % based on total lipid, wherein improving behaviour is selected from (a) increasing novel object recognition; (b) increasing the preference for novelty; (c) increasing the attention for surroundings; and (d) increasing exploratory behaviour and/or exploratory activity.
Type:
Application
Filed:
August 17, 2015
Publication date:
September 28, 2017
Applicant:
N.V. Nutricia
Inventors:
Annemiek Lidewij SCHIPPER, Eline Marleen VAN DER BEEK, Nana BARTKE
Abstract: Compositions and methods for providing infant nutrition with partially hydrolysed proteins and non-digestible oligosaccharides for use in induction of oral tolerance against native dietary proteins.
Type:
Grant
Filed:
January 14, 2016
Date of Patent:
September 26, 2017
Assignee:
N.V. NUTRICIA
Inventors:
Léon Mathieu Johannes Knippels, Elisabeth Catharina Adriana Maria van Esch, Johan Garssen
Abstract: A carbohydrate mixture for dietetic foods and pharmaceuticals is provided. The carbohydrate mixture comprises two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed. Carbohydrate component A may comprise at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or a mixture of two or more of these saccharides. Carbohydrate component B may comprise a polysaccharide (from heptasaccharide onwards) or a mixture of two or more polysaccharides. Carbohydrate component A=5 to 95 wt-% and carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and at least 80 wt-% of the carbohydrates/saccharides of both carbohydrate components have a prebiotic effect. The carbohydrate mixtures have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.
Abstract: The invention relates to a composition for use in the treatment or prevention of recognition dysfunction, and/or for improving recognition, in a (prodromal) Alzheimer's patient, in particular in a drug-naive (prodromal) Alzheimer's patient, more particularly in a subject with a mini-mental state examination of 20-30.
Abstract: The present invention relates to the use of nutritional compositions enriched in glutamine to improve structural and functional brain development in preterm and/or low birth weight infants.
Type:
Application
Filed:
January 13, 2017
Publication date:
September 14, 2017
Applicant:
N.V. Nutricia
Inventors:
Roelof Matthijs VAN ELBURG, Günther BOEHM
Abstract: The present invention relates to compressed solid milk tablets, a method for producing the same and a modular system for carrying out said method. The method comprises: (a) compressing milk powder to obtain compressed solid milk units with a mechanical strength between 10 kPa and 300 kPa, (b) humidifying the compressed solid milk units by exposing them in a humidifying chamber to humid air having a relative humidity of more than 95% and a temperature between 60 and 90° C., wherein the humid air comprises condensed water vapour, and (c) drying the humidified and compressed solid milk units to obtain compressed solid milk tablets. The tablets obtained by this method have a mechanical strength between 20 kPa and 1000 kPa, a core/crust structure, wherein the crust comprises milk particles that are solidified and fused in parallel and perpendicular planes, relative to the tablet surface, and a friability of less than 5%.
Type:
Application
Filed:
August 31, 2015
Publication date:
September 7, 2017
Applicants:
N.V. Nutricia, Eurotab Innovation
Inventors:
Valérie Elvira Suzanne CHAURIN, Maarten VALK, Martijn Johannes VAN DER HOEVEN, Gerardus Johannes COENEN
Abstract: Nutritional compositions with fucosyllactose and betagalactooligosaccharides for use in stimulation of the immune system. The composition is suitable for infants.
Type:
Application
Filed:
November 23, 2016
Publication date:
August 17, 2017
Applicant:
N.V. Nutricia
Inventors:
Bernd STAHL, Alma Jildou NAUTA, Johan GARSSEN, Eric SAMAIN, Sophie DROUILLARD