Patents Assigned to Nabsys, Inc.
  • Patent number: 8926813
    Abstract: Devices and methods for detecting the length of analytes, and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a fluidic channel. Detection of the relative position of probes hybridized to a biopolymer and/or the length of the analyte (e.g., a biopolymer) does not rely on the absolute time between detection events of a given electrical signal to determine a distance associated with the biopolymer. Instead, multiple signals are obtained as functions of time) corresponding to a plurality of detector volumes at known locations along a fluidic channel through which the biopolymer passes, and the distances are determined from the multiple signals.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: January 6, 2015
    Assignee: Nabsys, Inc.
    Inventor: John S. Oliver
  • Patent number: 8715933
    Abstract: Assay methods and apparatus for the analysis of biopolymers are disclosed. The assays employ nicking endonucleases to enable the generation of flaps on target biomolecules which are detected in nanopore or fluidic channel devices. Identification of flap locations enables a map of the target biomolecule to be derived.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: May 6, 2014
    Assignee: Nabsys, Inc.
    Inventor: John S. Oliver
  • Patent number: 8278047
    Abstract: Methods for sequencing a biopolymer by forming local ternary complexes along the length of the double-stranded biopolymer target molecule using one or more probes and obtaining information about the location of the probe(s) using a detector. These methods offer particular advantage when implemented with nanopore (including micropore) detection systems.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: October 2, 2012
    Assignee: Nabsys, Inc.
    Inventors: John Oliver, Barrett Bready, Peter Goldstein, Franco Preparata
  • Patent number: 8262879
    Abstract: Devices and methods for detecting the length of analytes and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a fluidic channel. Detection of the relative position of probes hybridized to a biopolymer and/or the length of the analyte (e.g., a biopolymer) does not rely on the absolute time between detection events of a given electrical signal to determine a distance associated with the biopolymer. Instead, multiple signals are obtained (e.g., as functions of time) corresponding to a plurality of detector volumes at known locations along a fluidic channel through which the biopolymer passes, and the distances are determined from the multiple signals.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: September 11, 2012
    Assignee: Nabsys, Inc.
    Inventor: John S. Oliver
  • Patent number: 8246799
    Abstract: Devices and methods for detecting the length of analytes and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a nanopore or fluidic channel. Detection of the relative position of probes hybridized to a biomolecule and/or the length of the analyte (e.g., a biomolecule) rely on detection events to determine a distance associated with the biomolecule. Multiple signals may be obtained (e.g., as functions of time) corresponding to a plurality of detector volumes at known locations along a fluidic channel through which the biomolecule passes, and the distances may be determined from the multiple signals.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 21, 2012
    Assignee: Nabsys, Inc.
    Inventors: John S. Oliver, Petre Ianakiev