Abstract: Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain.
Type:
Grant
Filed:
December 5, 2016
Date of Patent:
September 5, 2017
Assignee:
NAEJA-RGM PHARMACEUTICALS INC.
Inventors:
Samarendra Nath Maiti, Dai Quoc Nguyen, Andhe V. N. Reddy, Judy Yip, Chan Minh Ha, Rong Ling, Rudong Shan, Madhava Reddy Madala