Patents Assigned to Nagaoka & Co., Ltd.
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Publication number: 20180332879Abstract: A improving agent for improving aftertaste having high-intensity sweeteners according to the present disclosure contains isobutyl angelate as an active ingredient. A method for improving a sweet taste according to the present disclosure includes adding 0.001 to 1 ppm of isobutyl angelate to an oral composition containing a high-intensity sweetener.Type: ApplicationFiled: May 18, 2018Publication date: November 22, 2018Applicant: Nagaoka Co., Ltd.Inventors: Seiji HASHIMOTO, Kimihiro HIGASHI, Syunsuke YOSHINAGA, Tatsunori TAKIMOTO, Jyunji TOBARI, Nozomu HIRATA, Hirokazu KANENO
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Publication number: 20180332878Abstract: A bitter taste inhibitor according to the present disclosure contains isobutyl angelate as an active and a given solvent or a given excipient.Type: ApplicationFiled: May 18, 2018Publication date: November 22, 2018Applicant: NAGAOKA CO., LTD.Inventors: Seiji HASHIMOTO, Kimihiro HIGASHI, Tatsunori TAKIMOTO, Jyunji TOBARI, Nozomu HIRATA
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Patent number: 8785698Abstract: Embodiments are provided that provide for efficient production of highly pure natural I-menthol. In some embodiments, a method for preparing natural I-menthol involves providing crude mentha oil in a crystallizer and gradually reducing the temperature of the crystallizer in a step-wise manner, thereby producing highly pure crystals in less than two weeks. The methods disclosed herein are suitable for pharmaceutical GMP.Type: GrantFiled: February 17, 2010Date of Patent: July 22, 2014Assignee: Nagaoka & Co., Ltd.Inventors: Ryosuke Nagaoka, Hideaki Izukura, Susumu Tokita, Yuri Shibata, Yoshiyuki Nagaoka
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Publication number: 20110313205Abstract: Embodiments are provided that provide for efficient production of highly pure natural I-menthol. In some embodiments, a method for preparing natural I-menthol involves providing crude mentha oil in a crystallizer and gradually reducing the temperature of the crystallizer in a step-wise manner, thereby producing highly pure crystals in less than two weeks. The methods disclosed herein are suitable for pharmaceutical GMP.Type: ApplicationFiled: February 17, 2010Publication date: December 22, 2011Applicant: NAGAOKA & CO. LTD.Inventors: Ryosuke Nagaoka, Hideaki Izukura, Susumu Tokita, Yuri Shibata, Yoshiyuki Nagaoka
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Patent number: 7820213Abstract: The invention provide a gum base composition which has an excellent chewing texture and is disintegratable and biodegradable comprising biodegradable ingredients, including a lactic acid polymer comprising a poly-L-lactic acid polymer and/or other lactic acid polymers having a glass transition temperature higher than 50° C. in an amount of from 5% by weight to 60% by weight, and an emulsifying plasticizer in an amount of from 1% by weight to 20% by weight. The weight average molecular weight of the lactic acid polymer to be used is preferably 50,000 to 200,000.Type: GrantFiled: July 22, 2003Date of Patent: October 26, 2010Assignee: Nagaoka & Co., Ltd.Inventors: Yoshinori Sato, Yoshiyuki Nagaoka
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Patent number: 7390464Abstract: A fluidic circuit for receiving a fluid and separating a component of a fluid from the fluid comprises a separation chamber for receiving the fluid, an air chamber in fluid communication with the separation chamber, and a return channel in fluid communication with the separation chamber. In an advantageous embodiment, the fluidic circuit is subjected to a force, such as a centrifugal force, so that substantially all of the component of the fluid is moved to the return channel while substantially all remaining portions of the fluid are moved to the separation chamber.Type: GrantFiled: July 26, 2004Date of Patent: June 24, 2008Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: Horacio Kido, James R. Norton, James H. Coombs
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Patent number: 7387898Abstract: A multi-well assay plate structure (54) and assay apparatus and a method for performing chemical biochemical assays is described. The multi-well assay plate structure (54) defines a relatively shallow substantially enclosed space (71) above a plurality of wells (76), with the enclosed space (71) having an inlet (72) and an outlet (22) separate from the inlet. Fluid introduced via the inlet (72) flows into the space (71) and/or wells (76) by displacing air. Withdrawal of the fluid via the inlet (72) or outlet leaves fluid in the wells (76) allowing various tests to be performed. Various embodiments of the structure are described. The preferred arrangement embodies the structure on a transparent plastic disk which can be used with automatic fluid handling apparatus (80) and the results assessed using optical assessment apparatus (81).Type: GrantFiled: October 8, 1997Date of Patent: June 17, 2008Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventor: John Francis Gordon
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Patent number: 7366063Abstract: This invention directs to an optical disc assembly configured to receive an analyte which can be detected by a standard optical disc reader or an optical disc reader modified therefrom. The optical disc assembly may preferably be designed so that the optical disc reader can track the disc and detect the analyte concurrently and discriminably. The optical disc assembly contains or encodes optically readable features which are trackable by the optical disc reader and which have encoded speed information enabling the optical disc reader to rotate the optical disc assembly at a determinable speed. The optical disc assembly also includes an analyte section capable of receiving the analyte that can be detected by the optical disc reader.Type: GrantFiled: July 18, 2006Date of Patent: April 29, 2008Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: Mark O. Worthington, James R. Norton, Horacio Kido, Victor M. Ortiz
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Publication number: 20080094974Abstract: An optical disc system includes a photo detector circuit of an optical disc drive and a signal processing system. The photo detector circuit is configured to generate at least one information-carrying signal from an optical disc assembly. The signal processing system is coupled to the photo detector circuit to obtain from the at least one information-carrying signal both operational information used to operate the optical disc system and data indicative of presence and/or characteristics of an investigational feature associated with the optical disc assembly. Methods and discs for imaging a biological or medical investigational feature are also provided.Type: ApplicationFiled: May 18, 2007Publication date: April 24, 2008Applicants: BURSTEIN TECHNOLOGIES, INC., NAGAOKA & CO., LTD.Inventor: Mark Worthington
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Publication number: 20070264722Abstract: An optical analysis disc includes grooves defining corresponding laser-readable tracks and trigger marks that identify respective target regions on the disc. The trigger marks are implemented as a radial interruption of the grooves to thereby produce an increased reflection of a laser beam. There is also provided an optical analysis disc system including a trigger mechanism having a trigger detector adapted to detect interruptions in grooves of an optical analysis disc. A related method for triggering through interrupted grooves of an optical analysis disc includes detecting interruption in the grooves, generating an electrical reflection signal corresponding to the interruptions detected, and elaborating said reflection signal, so that to generate a trigger signal.Type: ApplicationFiled: July 20, 2007Publication date: November 15, 2007Applicants: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: James Coombs, Kevin McIntyre, Mark Worthington
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Patent number: 7251210Abstract: An optical analysis disc includes grooves defining corresponding laser-readable tracks and trigger marks that identify respective target regions on the disc. The trigger marks are implemented as a radial interruption of the grooves to thereby produce an increased reflection of a laser beam. There is also provided an optical analysis disc system including a trigger mechanism having a trigger detector adapted to detect interruptions in grooves of an optical analysis disc. A related method for triggering through interrupted grooves of an optical analysis disc includes detecting interruption in the grooves, generating an electrical reflection signal corresponding to the interruptions detected, and elaborating said reflection signal, so that to generate a trigger signal.Type: GrantFiled: January 23, 2003Date of Patent: July 31, 2007Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: James Howard Coombs, Kevin Robert McIntyre, Mark Oscar Worthington
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Patent number: 7221632Abstract: An optical disc system includes a photo detector circuit of an optical disc drive and a signal processing system. The photo detector circuit is configured to generate at least one information-carrying signal from an optical disc assembly. The signal processing system is coupled to the photo detector circuit to obtain from the at least one information-carrying signal both operational information used to operate the optical disc system and data indicative of presence and/or characteristics of an investigational feature associated with the optical disc assembly. Methods and discs for imaging a biological or medical investigational feature are also provided.Type: GrantFiled: July 12, 2002Date of Patent: May 22, 2007Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventor: Mark Oscar Worthington
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Patent number: 7200088Abstract: An optical disc system includes a photo detector circuit of an optical disc drive and a signal processing system. The photo detector circuit is configured to generate at least one information-carrying signal from an optical disc assembly. The signal processing system is coupled to the photo detector circuit to obtain from the at least one information-carrying signal both operational information used to operate the optical disc system and data indicative of presence and/or characteristics of an investigational feature associated with the optical disc assembly. Methods and discs for imaging a biological or medical investigational feature are also provided.Type: GrantFiled: January 10, 2002Date of Patent: April 3, 2007Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: Mark Oscar Worthington, Stephen Kou-An Shu, Kevin Robert McIntyre
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Patent number: 7200100Abstract: This invention relates to an optical disc assembly capable of receiving an insert upon which an analyte of interest may be disposed. The optical disc assembly can be read by an optical disc reader, such as by a standard CD or DVD reader, and the analyte disposed on the insert can be detected by the optical disc reader. The optical disc assembly may have one or more data layer in which operational information or assay information is encoded. Hologram may be used to encode operational information or assay information.Type: GrantFiled: May 30, 2006Date of Patent: April 3, 2007Assignees: Nagaoka & Co., Ltd., Burstein Technologies, Inc.Inventor: Mark Oscar Worthington
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Patent number: 7157049Abstract: The present invention is directed to optical bio-discs, methods, and optical disc drives for clinical diagnostics. The present invention is further directed to methods for determining the quantity of a specific type of blood cell in a biological sample including on-disc sample preparation and processing, providing a pre-processed sample onto a capture zone, removing portions of the sample that are not bound in the capture zone, and counting bound cells. Also disclosed are fluidic circuits for processing blood samples for use in a cluster designation marker assay in the optical bio-disc.Type: GrantFiled: November 13, 2002Date of Patent: January 2, 2007Assignee: Nagaoka & Co., Ltd.Inventors: Ramoncito Magpantay Valencia, YihFar Chen, Susan Newcomb Hurt, Joseph Roby Iringan Urcia, Gowri Pyapali Selvan
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Publication number: 20060257939Abstract: A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also provided.Type: ApplicationFiled: July 25, 2006Publication date: November 16, 2006Applicants: BURSTEIN TECHNOLOGIES, INC., NAGAOKA & CO., LTDInventor: James Demers
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Publication number: 20060250930Abstract: This invention directs to an optical disc assembly configured to receive an analyte which can be detected by a standard optical disc reader or an optical disc reader modified therefrom. The optical disc assembly may preferably be designed so that the optical disc reader can track the disc and detect the analyte concurrently and discriminably. The optical disc assembly contains or encodes optically readable features which are trackable by the optical disc reader and which have encoded speed information enabling the optical disc reader to rotate the optical disc assembly at a determinable speed. The optical disc assembly also includes an analyte section capable of receiving the analyte that can be detected by the optical disc reader.Type: ApplicationFiled: July 18, 2006Publication date: November 9, 2006Applicants: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: Mark Worthington, James Norton, Horacio Kido, Victor Ortiz
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Patent number: 7110345Abstract: This invention relates to optical discs that preferably include multiple data layers and are configured to receive analytes which can be detected by an optical disc reader. The optical disc reader may be a standard optical disc reader or an optical disc reader modified therefrom. The optical disc may include (1) a first layer including optically readable structures which have encoded tracking information, and speed information enabling an optical disc reader to rotate the optical disc at a speed that is determinable from the speed information; (2) a second layer including optically readable structures; and (3) an analyte section capable of receiving an analyte which can be read by the optical disc reader.Type: GrantFiled: July 6, 2004Date of Patent: September 19, 2006Assignees: Burstein Technologies, Inc., Nagaoka & Co., Ltd.Inventors: Mark O. Worthington, James R. Norton, Horacio Kido, Victor M. Ortiz
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Patent number: 7110094Abstract: A system for conducting an optical inspection of a biological, chemical, or biochemical sample supported by an optically transparent disc. The disc is mounted for rotation about its central axis while a light source and a plurality of radiation detectors are provided for scanning optically readable portions and tracking information encoded to the disc and scanning the sample. The source is arranged above the disc and the detectors are arranged above and below the disc. The optical properties of the sample can be automatically and rapidly inspected by analyzing the output of the light detectors including the use of a ratio of first and second detector output. A third detector output also may be used in the analysis.Type: GrantFiled: November 16, 2001Date of Patent: September 19, 2006Assignees: Burstein Technologies, Inc., Nagaoka & Co. LTDInventor: John Francis Gordon
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Patent number: 7094609Abstract: A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also provided.Type: GrantFiled: September 19, 1997Date of Patent: August 22, 2006Assignees: Burstein Technologies, Inc., Nagaoka & Co. Ltd.Inventor: James Paul Demers