Patents Assigned to Nagasaki University
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Publication number: 20220174942Abstract: Provided is a storage container for storing a cornea specimen in which an endothelium and an epithelium of a cornea can be immersed and stored in different storage solutions.Type: ApplicationFiled: February 25, 2022Publication date: June 9, 2022Applicant: Nagasaki UniversityInventors: Masafumi UEMATSU, Takashi KITAOKA
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Publication number: 20200367737Abstract: A cover (220, 320, 420) for covering a part in a circumferential direction of an outer circumferential surface of a rigid endoscope 10 includes an outer cover portion (222, 322, 422) having flexibility and an inner cover portion (223, 323, 423) provided on an inner surface of the outer cover portion (222, 322, 422) and configured to define a flow passage for a washing fluid to be supplied to an observation window portion 14 of the rigid endoscope 10, and the outer cover portion(222, 322, 422) is mounted onto the outer circumferential surface of the rigid endoscope 10 by the outer cover portion (222, 322, 422) bending.Type: ApplicationFiled: August 2, 2017Publication date: November 26, 2020Applicants: Nagasaki University, TryTec Co., Ltd.Inventors: Keitaro MATSUMOTO, Takeshi NAGAYASU, Katsunori TAKAGI, Hiroshi TAKEZAKI, Junji MORI
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Patent number: 10734726Abstract: A planar antenna includes a patch conductor formed on a front surface of a dielectric substrate 20 so to be obliquely arranged in relation to an orthogonal axis of the dielectric substrate, the patch conductor having an elliptic shape; a microstrip line 40 for feeding power to a bottom part of the patch conductor; and a ground conductor plate 50 formed on a back surface of the dielectric substrate at a position thereof that is not overlapped with the patch conductor. By forming the patch conductor to be inclined only by ?, circular polarization characteristics in which axial ratio is 3 dB or less are given and the wideband such that the frequency bandwidth in which VSWR characteristics are 2 or less is 2 through 5 GHz and the wideband in UWB High band can be attained. The antenna characteristics in which any radiation directivity on the zenith direction does not depend on the frequency are obtained.Type: GrantFiled: November 12, 2015Date of Patent: August 4, 2020Assignee: Nagasaki UniversityInventor: Takafumi Fujimoto
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Patent number: 10563249Abstract: According to one embodiment, there is provided a nucleic acid primer set that amplifies a ZEBOV gene. An F1 sequence includes at least 13 consecutive bases included in SEQ ID NO: 31 or 64. An F2 sequence includes at least 13 bases included in SEQ ID NO: 62 or 63. An F3 sequence includes at least 13 bases included in SEQ ID NO: 29, 36, 38, 55, 56, 57, 58, 59, 60, 61 or 61. A B1c sequence includes at least 13 bases included in SEQ ID NO: 68, 69, 70, 71, 72, 73, 74 or 75. A B2c sequence includes at least 13 bases included in SEQ ID NO: 65 or 66. A B3c sequence includes at least 13 bases included in SEQ ID NO: 34, 67, 82 or 83.Type: GrantFiled: June 19, 2017Date of Patent: February 18, 2020Assignees: Nagasaki University, Canon Madical Systems CorporationInventors: Jiro Yasuda, Yohei Kurosaki
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Patent number: 10280188Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.Type: GrantFiled: February 1, 2016Date of Patent: May 7, 2019Assignee: Nagasaki UniversityInventors: Yoshimasa Tanaka, Satoshi Mizuta, Hiroshi Ueda
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Patent number: 10183007Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.Type: GrantFiled: December 21, 2015Date of Patent: January 22, 2019Assignees: Usien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd., Nagasaki UniversityInventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
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Patent number: 10130357Abstract: To reduce the risk of damaging organs in a body while delivering a thread during surgery, an instrument for delivering a surgical thread has a grip, an outer cylinder fixed the grip, a hollow needle extending inside the outer cylinder and being configured to be moved relative to the outer cylinder in an axial direction and a loop configured to be housed in the outer cylinder. An end of the outer cylinder is bent in a state where force is not applied. The hollow needle is exposed from the outer cylinder when puncturing skin or etc., and the hollow needle is housed in the outer cylinder when it travels near organs which should not be damaged.Type: GrantFiled: March 26, 2015Date of Patent: November 20, 2018Assignee: Nagasaki UniversityInventors: Susumu Eguchi, Tamotu Kuroki, Taiichiro Kosaka, Takakazu Ishimatu, Syunji Moromugi
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Patent number: 9939404Abstract: A CO sensor includes a solid electrolyte substrate, a sensing electrode, and a reference electrode, and outputs electromotive forces in accordance with CO concentrations. The sensing electrode and the reference electrode are provided on the same surface of the solid electrolyte substrate. The sensing electrode contains a metal oxide such as Bi2O3 that generates a positive electromotive force response when coming into contact with CO. The reference electrode contains a metal oxide such as CeO2 that generates a negative electromotive force response when coming into contact with CO.Type: GrantFiled: February 5, 2016Date of Patent: April 10, 2018Assignees: Figaro Engineering Inc., Nagasaki UniversityInventors: Yasuhiro Shimizu, Takeo Hyodo, Taro Ueda, Hirotaka Takeda, Kai Kamada
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Publication number: 20180054001Abstract: A planar antenna includes a patch conductor formed on a front surface of a dielectric substrate 20 so to be obliquely arranged in relation to an orthogonal axis of the dielectric substrate, the patch conductor having an elliptic shape; a microstrip line 40 for feeding power to a bottom part of the patch conductor; and a ground conductor plate 50 formed on a back surface of the dielectric substrate at a position thereof that is not overlapped with the patch conductor. By forming the patch conductor to be inclined only by ?, circular polarization characteristics in which axial ratio is 3 dB or less are given and the wideband such that the frequency bandwidth in which VSWR characteristics are 2 or less is 2 through 5 GHz and the wideband in UWB High band can be attained. The antenna characteristics in which any radiation directivity on the zenith direction does not depend on the frequency are obtained.Type: ApplicationFiled: December 11, 2015Publication date: February 22, 2018Applicants: Nagasaki University, GIT Japan IncorporatedInventor: Takafumi FUJIMOTO
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Publication number: 20180022769Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.Type: ApplicationFiled: February 1, 2016Publication date: January 25, 2018Applicant: Nagasaki UniversityInventors: Yoshimasa TANAKA, Satoshi MIZUTA, Hiroshi UEDA
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Publication number: 20170369940Abstract: According to one embodiment, there is provided a nucleic acid primer set that amplifies a ZEBOV gene. An F1 sequence includes at least 13 consecutive bases included in SEQ ID NO: 31 or 64. An F2 sequence includes at least 13 bases included in SEQ ID NO: 62 or 63. An F3 sequence includes at least 13 bases included in SEQ ID NO: 29, 36, 38, 55, 56, 57, 58, 59, 60, 61 or 61. A B1c sequence includes at least 13 bases included in SEQ ID NO: 68, 69, 70, 71, 72, 73, 74 or 75. A B2c sequence includes at least 13 bases included in SEQ ID NO: 65 or 66. A B3c sequence includes at least 13 bases included in SEQ ID NO: 34, 67, 82 or 83.Type: ApplicationFiled: June 19, 2017Publication date: December 28, 2017Applicants: Nagasaki University, Toshiba Medical Systems CorporationInventors: Jiro YASUDA, Yohei Kurosaki
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Patent number: 9763973Abstract: The present invention provides a or therapeutic agent for HAM, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention also provides an agent for improving a HAM-associated movement disorder, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: October 12, 2012Date of Patent: September 19, 2017Assignees: Nagasaki University, ReqMed Company, Ltd.Inventors: Tatsufumi Nakamura, Tadashi Matsumoto
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Patent number: 9481893Abstract: The invention provides nucleotide sequences that function as enhancers and induce osteoblast-specific expression, expression vectors comprising such an enhancer, a promoter, and a gene containing a coding region, as well as screening methods utilizing such expression vectors.Type: GrantFiled: August 6, 2010Date of Patent: November 1, 2016Assignee: Nagasaki UniversityInventors: Toshihisa Komori, Shinichi Izumi, Toshihiro Miyazaki, Satoshi Rokutanda, Hisato Komori, Wenguang Liu
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Publication number: 20160151329Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.Type: ApplicationFiled: December 21, 2015Publication date: June 2, 2016Applicants: Nagasaki University, Usaien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd.Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
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Patent number: 9265751Abstract: The invention provides a method of treating chronic pain by administering an effective amount of a low-molecular weight compound that inhibits the enzyme activity of autotaxin to a subject in need thereof, thereby treating chronic pain in the subject. The chronic pain preferably is fibromyalgia, chronic fatigue syndrome, or hypersensitivity colitis.Type: GrantFiled: June 30, 2014Date of Patent: February 23, 2016Assignees: Nagasaki University, Kabushiki Kaisha M.S.SInventor: Hiroshi Ueda
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Patent number: 9259487Abstract: The present invention provides a non-human mammal deficient in the expression of prothymosin ? gene in the striatum and a screening method for a prophylactic/therapeutic drug for Huntington's disease and the like, which uses the animal.Type: GrantFiled: May 18, 2012Date of Patent: February 16, 2016Assignee: Nagasaki UniversityInventor: Hiroshi Ueda
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Patent number: 9028797Abstract: The invention provides an antigen or drug delivery complex containing a complex of an antigen or drug and a cationic molecule, and an anionic molecule encapsulating the same. The antigen or drug delivery complex can be used as a main component of a drug delivery system that delivers various antigens and drugs to a particular cell or organ.Type: GrantFiled: February 24, 2011Date of Patent: May 12, 2015Assignees: Nagasaki University, Kyusyu University Corporation, National University Corporation Hamamatsu University School of MedicineInventors: Hitoshi Sasaki, Tomoaki Kurosaki, Takashi Kitahara, Hideto To, Katsuyuki Yui, Kenji Hirayama, Kouichi Morita, Takahiro Mukai, Yasuhiro Magata, Mikako Ogawa, Kohei Sano
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Patent number: 9023835Abstract: The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin ?, or a protein or polypeptide possessing the same function as the prothymosin ?. The invention also provides polypeptides useful in the context of the aforesaid methods.Type: GrantFiled: August 9, 2010Date of Patent: May 5, 2015Assignee: Nagasaki UniversityInventor: Hiroshi Ueda
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Patent number: 8969585Abstract: Provided is a process for producing an optically active compound represented by Formula (3): (wherein R1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R1 may be replaced with a substituent; R2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R1 and R2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): MmZn??(2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.Type: GrantFiled: January 31, 2012Date of Patent: March 3, 2015Assignee: Nagasaki UniversityInventors: Osamu Onomura, Yutaro Tsuda, Masami Kuriyama, Toshiharu Yanagi, Kazuya Kodama
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Patent number: 8871520Abstract: The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).Type: GrantFiled: March 1, 2011Date of Patent: October 28, 2014Assignee: Nagasaki UniversityInventors: Masaaki Kai, Takayuki Shibata