Patents Assigned to Nagasaki University
  • Patent number: 10280188
    Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: May 7, 2019
    Assignee: Nagasaki University
    Inventors: Yoshimasa Tanaka, Satoshi Mizuta, Hiroshi Ueda
  • Patent number: 10183007
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 22, 2019
    Assignees: Usien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd., Nagasaki University
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 10175229
    Abstract: The present invention aims to provide a novel compound for measuring cellular cytotoxicity or cell proliferation capacity accurately with high reproducibility, conveniently and rapidly, and a measurement method of cellular cytotoxicity or cell proliferation capacity by using the compound. The present invention relates to a compound represented by the formula (I): wherein R1 is a substituent, R2 and R3 are each an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, Y is a substituent, n is an integer of 0-3, Z is a single bond, —O—, —S—, —SO—, —SO2—, or —NR4— (R4 is a hydrogen atom or a substituent), and A is an optionally substituted C1-6 alkylene group) or a salt thereof.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 8, 2019
    Assignee: NAGASAKI UNIVERSITY
    Inventors: Yoshimasa Tanaka, Yuki Sakai, Satoshi Mizuta, Hiroshi Ueda
  • Patent number: 10130357
    Abstract: To reduce the risk of damaging organs in a body while delivering a thread during surgery, an instrument for delivering a surgical thread has a grip, an outer cylinder fixed the grip, a hollow needle extending inside the outer cylinder and being configured to be moved relative to the outer cylinder in an axial direction and a loop configured to be housed in the outer cylinder. An end of the outer cylinder is bent in a state where force is not applied. The hollow needle is exposed from the outer cylinder when puncturing skin or etc., and the hollow needle is housed in the outer cylinder when it travels near organs which should not be damaged.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: November 20, 2018
    Assignee: Nagasaki University
    Inventors: Susumu Eguchi, Tamotu Kuroki, Taiichiro Kosaka, Takakazu Ishimatu, Syunji Moromugi
  • Publication number: 20180282733
    Abstract: The present invention provides a therapeutic agent for a muscle weakness symptom (sarcopenia) or a metabolic disease, containing a ?-crystallin (CRYM) inhibitory substance as an active ingredient. The inhibitory substance is selected from the group consisting of an antisense nucleic acid against CRYM, an RNAi-inducing nucleic acid against CRYM and a ribozyme against CRYM, expression vectors of these, an antagonist antibody against CRYM, and a low molecular weight compound that inhibits activity of CRYM.
    Type: Application
    Filed: September 9, 2016
    Publication date: October 4, 2018
    Applicant: NAGASAKI UNIVERSITY
    Inventor: Yusuke ONO
  • Patent number: 9980937
    Abstract: The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: May 29, 2018
    Assignee: NAGASAKI UNIVERSITY
    Inventors: Nobuhisa Iwata, Keiro Shirotani, Masashi Asai, Takashi Tanaka
  • Patent number: 9976968
    Abstract: There is provided a crack detection system in which a crack can be detected from a strain distribution of a part to be detected of an object. After taking the image of the part to be detected of the detection object by the imaging unit, the heat is applied by the heating unit. Furthermore, image of the part to be detected are taken again and an image analysis unit analyzes the images before and after applying the heat to acquire a strain distribution of the part to be detected, so that the crack can be detected based on difference in a state of strain between a place where the crack exist and the other place. Therefore, taking the images of the part to be detected including its coating layer enables the analysis to progress without removing the coating layer to detect the crack.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 22, 2018
    Assignees: SAGA UNIVERSITY, NAGASAKI UNIVERSITY
    Inventors: Yukihiro Ito, Kazuhisa Shiki, Hiroshi Matsuda, Akira Demizu
  • Patent number: 9939404
    Abstract: A CO sensor includes a solid electrolyte substrate, a sensing electrode, and a reference electrode, and outputs electromotive forces in accordance with CO concentrations. The sensing electrode and the reference electrode are provided on the same surface of the solid electrolyte substrate. The sensing electrode contains a metal oxide such as Bi2O3 that generates a positive electromotive force response when coming into contact with CO. The reference electrode contains a metal oxide such as CeO2 that generates a negative electromotive force response when coming into contact with CO.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: April 10, 2018
    Assignees: Figaro Engineering Inc., Nagasaki University
    Inventors: Yasuhiro Shimizu, Takeo Hyodo, Taro Ueda, Hirotaka Takeda, Kai Kamada
  • Publication number: 20180054001
    Abstract: A planar antenna includes a patch conductor formed on a front surface of a dielectric substrate 20 so to be obliquely arranged in relation to an orthogonal axis of the dielectric substrate, the patch conductor having an elliptic shape; a microstrip line 40 for feeding power to a bottom part of the patch conductor; and a ground conductor plate 50 formed on a back surface of the dielectric substrate at a position thereof that is not overlapped with the patch conductor. By forming the patch conductor to be inclined only by ?, circular polarization characteristics in which axial ratio is 3 dB or less are given and the wideband such that the frequency bandwidth in which VSWR characteristics are 2 or less is 2 through 5 GHz and the wideband in UWB High band can be attained. The antenna characteristics in which any radiation directivity on the zenith direction does not depend on the frequency are obtained.
    Type: Application
    Filed: December 11, 2015
    Publication date: February 22, 2018
    Applicants: Nagasaki University, GIT Japan Incorporated
    Inventor: Takafumi FUJIMOTO
  • Publication number: 20180022769
    Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.
    Type: Application
    Filed: February 1, 2016
    Publication date: January 25, 2018
    Applicant: Nagasaki University
    Inventors: Yoshimasa TANAKA, Satoshi MIZUTA, Hiroshi UEDA
  • Publication number: 20170369940
    Abstract: According to one embodiment, there is provided a nucleic acid primer set that amplifies a ZEBOV gene. An F1 sequence includes at least 13 consecutive bases included in SEQ ID NO: 31 or 64. An F2 sequence includes at least 13 bases included in SEQ ID NO: 62 or 63. An F3 sequence includes at least 13 bases included in SEQ ID NO: 29, 36, 38, 55, 56, 57, 58, 59, 60, 61 or 61. A B1c sequence includes at least 13 bases included in SEQ ID NO: 68, 69, 70, 71, 72, 73, 74 or 75. A B2c sequence includes at least 13 bases included in SEQ ID NO: 65 or 66. A B3c sequence includes at least 13 bases included in SEQ ID NO: 34, 67, 82 or 83.
    Type: Application
    Filed: June 19, 2017
    Publication date: December 28, 2017
    Applicants: Nagasaki University, Toshiba Medical Systems Corporation
    Inventors: Jiro YASUDA, Yohei Kurosaki
  • Publication number: 20170360811
    Abstract: The novel bisphosphonic acid ester derivatives represented by the following formula (1): Y—Cy—(NH)m—(CH2)n—C(X)(PO(OR1)(OR2))2 ??(1) wherein each symbol is as defined in the DESCRIPTION, which has an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom, and the acid moiety is esterified with a POM group, an n-butanoyloxymethyl (BuOM) group and the like, exhibit a superior direct or indirect cytotoxicity effect on tumor cells and virus infected cells.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 21, 2017
    Applicant: NAGASAKI UNIVERSITY
    Inventors: Yoshimasa TANAKA, Kenji MATSUMOTO, Kosuke HAYASHI, Yuki SAKAI, Nagahiro MINATO
  • Patent number: 9763973
    Abstract: The present invention provides a or therapeutic agent for HAM, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention also provides an agent for improving a HAM-associated movement disorder, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: September 19, 2017
    Assignees: Nagasaki University, ReqMed Company, Ltd.
    Inventors: Tatsufumi Nakamura, Tadashi Matsumoto
  • Publication number: 20170252318
    Abstract: The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.
    Type: Application
    Filed: March 16, 2017
    Publication date: September 7, 2017
    Applicant: NAGASAKI UNIVERSITY
    Inventors: Nobuhisa IWATA, Keiro SHIROTANI, Masashi ASAI, Takashi TANAKA
  • Publication number: 20170128062
    Abstract: [Problem] To reduce the risk of damaging organs in a body while delivering a thread during surgery. [Means for Solving Problem] An instrument for delivering a surgical thread has a grip 10, an outer cylinder 70 fixed the grip, a hollow needle 80 extending inside the outer cylinder 70 and being configured to be moved relative to the outer cylinder 70 in an axial direction and a loop 90 configured to be housed in the outer cylinder 70. An end of the outer cylinder 70 is bent in a state where force is not applied. The hollow needle 80 is exposed from the outer cylinder 70 when puncturing skin or etc., and the hollow needle 80 is housed in the outer cylinder 70 when it travels near organs which should not be damaged.
    Type: Application
    Filed: March 26, 2015
    Publication date: May 11, 2017
    Applicant: NAGASAKI UNIVERSITY
    Inventors: Susumu EGUCHI, Tamotu KUROKI, Taiichiro KOSAKA, Takakazu ISHIMATU, Syunji MOROMUGI
  • Patent number: 9617324
    Abstract: To provide a peptide which can be produced and processed more readily compared with prothymosin ? , which is conventionally known, or a peptide thereof and has an activity at a level equivalent to or higher than that of prothymosin ? or a peptide thereof. The present invention provides an ameliorating agent for blood-organ barrier dysfunction, a therapeutic agent for diseases associated with blood-organ barrier dysfunction or ischemic diseases or a nerve cell death inhibitor, each comprising, as an active ingredient, a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 or a peptide having substantially the same function as that of the aforementioned peptide.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: April 11, 2017
    Assignee: NAGASAKI UNIVERSITY
    Inventor: Hiroshi Ueda
  • Patent number: 9595891
    Abstract: Provided are a control device and a control device for a power conversion circuit, said control device having a first control circuit that compensates for detection delays in an analog-to-digital conversion circuit of a second control circuit that compensates for response delays of the integral element and the derivative element of the first control circuit. A first control circuit (212), which has a first analog-to-digital converter at the input stage thereof, generates an amount of time, which is a first control amount, on the basis of sampling information for a controlled object, and applies an operation initiation signal to a second control circuit (222) when a period of time, lasting for the first control amount, has passed from a prescribed reference time.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: March 14, 2017
    Assignee: NAGASAKI UNIVERSITY
    Inventors: Fujio Kurokawa, Tsukasa Takahashi, Kouta Bansyou, Tooru Tanaka
  • Patent number: 9588524
    Abstract: Provided is a vibration control device, which enables the vibrations of a vibrating body, such as a rotary machine, to automatically be suppressed, without installing a vibration detection sensor on the vibration control device or vibrating body, and without controlling the rotational speed or phase of the vibration control device. The vibration control device (1), which is installed on a vibrating body (2) and controls the vibrations of the vibrating body (2), comprises a rotating shaft (11), a mass body (12) that is fixed to the rotating shaft (11), and an activation apparatus (13) that adds the power of a rotational motion, which is centered on the rotating shaft (11), to the mass body (12).
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: March 7, 2017
    Assignees: NAGASAKI UNIVERSITY, MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Yutaka Yoshitake, Shuhei Kajiwara
  • Publication number: 20170016880
    Abstract: The present invention aims to provide a novel compound for measuring cellular cytotoxicity or cell proliferation capacity accurately with high reproducibility, conveniently and rapidly, and a measurement method of cellular cytotoxicity or cell proliferation capacity by using the compound. The present invention relates to a compound represented by the formula (I): wherein R1 is a substituent, R2 and R3 are each an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, Y is a substituent, n is an integer of 0-3, Z is a single bond, —O—, —S—, —SO—, —SO2—, or —NR4— (R4 is a hydrogen atom or a substituent), and A is an optionally substituted C1-6 alkylene group) or a salt thereof.
    Type: Application
    Filed: March 30, 2015
    Publication date: January 19, 2017
    Applicant: NAGASAKI UNIVERSITY
    Inventors: Yoshimasa TANAKA, Yuki SAKAI, Satoshi MIZUTA, Hiroshi UEDA
  • Patent number: 9543836
    Abstract: In a control device of a power converter circuit repeating accumulation of energy to an inductor and release of energy from the inductor at each turn on/turn off timing of a switch, a zero cross detecting circuit detects a time when a current flowing through the inductor becomes zero by inputting a voltage between both terminals of the inductor directly without any resistance for detecting the inductor current. There is no electricity loss caused by the resistance for detecting the inductor current and critical mode control of the power converter circuit is precisely carried out.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: January 10, 2017
    Assignees: NAGASAKI UNIVERSITY, PANASONIC CORPORATION
    Inventors: Fujio Kurokawa, Masahito Ohnishi