Abstract: The invention provides nucleotide sequences that function as enhancers and induce osteoblast-specific expression, expression vectors comprising such an enhancer, a promoter, and a gene containing a coding region, as well as screening methods utilizing such expression vectors.

Abstract: A reluctance motor according to an aspect of an embodiment includes a stator and a mover. One of the stator and the mover includes a plurality of magnetic poles on which coils are wound. The other of the stator and the mover includes a magnetic segment that includes a directivity member of which the magnetization direction is regulated in a predetermined direction and that is embedded into a non-magnetic holder.

Abstract: The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin ?, or a protein or polypeptide possessing the same function as the prothymosin ?. The invention also provides polypeptides useful in the context of the aforesaid methods.

Abstract: The present invention provides cutting methods and cutting apparatus that can precisely cut workpieces in complicated shapes with high aspect ratios regardless of materials of the workpieces. The present invention is cutting methods and cutting apparatus using a wire saw wherein cutting processing is performed for a workpiece by extending a cutting wire on a cutting arm that rotates around a wire's center axis or a real cutting position relative to a fixed section and rotating the cutting arm such that a cutting direction of the wire matches a support direction of a total stiffness that supports the wire.

Abstract: A composition for diagnosing amyloid-related diseases, which comprises a flavone derivative, a chalcone derivative, a styrylchromone derivative, or a coumarin derivative, is provided. These compounds have high binding specificity to an amyloid ? protein, high permeability to a blood-brain barrier, and ability to rapidly disappear from sites other than cerebral senile plaque. Accordingly, the composition of the present invention using these compounds enables the diagnosis of amyloid-related diseases with high precision.

Abstract: This invention provides a nano composite porous electrode material that has high charge-discharge behavior and charge or discharge capacity and a manufacturing method thereof. It also provides a lithium-ion secondary battery using this nano composite porous electrode material. The nano composite porous electrode material according to this invention has a porous structure such that nano-size pores are three-dimensionally connected with each other wherein walls of the pores thereof are composed of olivine type LiMnPO4 and carbon, a specific surface area Sa is 55 m2g?1<Sa<248 m2g?1, an amount of contained carbon Cc is 15.5 wt %<Cc<28 w t% and a diameter of crystallite is less than 39 nm. This enables a high charge-discharge capacity and a fast charge or discharge behavior to be obtained.

Abstract: This invention provides a macroporous graphite electrode material that may be manufactured at a low temperature of 1500° C. or less and may be fast charged and discharged and a manufacturing method thereof. It also provides a lithium-ion secondary battery using this macroporous graphite electrode material. The macroporous graphite electrode material according to this invention is composed of graphite having macropores in which a ratio of specific surface area of micropores in relation to total specific surface area is not less than 0 and not more than 0.74 and a ratio of D band area and G band area in Raman spectrum (D/G area ratio) is not less than 0 and not more than 1.33.

Abstract: Disclosed are a device and a method for comparing a detected frequency signal (first frequency signal) and a second frequency signal which is obtained by delaying the detected frequency, to determine whether the frequency transitioned to a predetermined area on high frequency side or reached a predetermined value on the upward direction side. The frequency detection device (1) comprises: a delayed signal output circuit (11) that outputs a second frequency signal (F2) obtained by delaying the first frequency signal (F1), which has a frequency that changes over time, by a set period (?i); and a determination circuit (12), which inputs the first frequency signal (F1) and the second frequency signal (F2), determines whether or not the cycle of the first frequency signal (F1) is included in the cycle of the second frequency signal (F2) and/or whether or not the cycle of the second frequency signal (F2) is included in the cycle of the first frequency signal (F1), and outputs a determination signal.

Abstract: Disclosed is a metal complex containing a composition represented by the following formula (a). [(PdII)2(MI)2(X)2(L)4(L?)2] (In the formula (a), MI represents AgI, AuI or CuI; X represents Cl, Br or I; L represents a group represented by formula (1); L? represents a group represented by formula (2); two MIs may be the same as or different from each other; four Ls may be the same as or different from each other; and two L's may be the same as or different from each other.) (In the formulae (1) and (2), R1, R2 and R3 independently represent a hydrogen atom, a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted monovalent heterocyclic group.

Abstract: The voltage deviation is converted into the time quantity with the first integration circuit for the voltage detection and the second integration circuit for the voltage detection. The current setting value and the current measurements are converted into the time quantity with the second integration circuit for the current control to which the first integration circuit for the current control from which the voltage value of the set current value corresponding is input and the voltage value of the value of the current of the inductor corresponding are input and it controls. And, the start of the first integration circuit for the current control is delayed with operation quantity signal generation circuit only at the time that the high-resolution evaluation or more than the start of the first integration circuit for the current control and corresponds to the voltage deviation.

Abstract: The control accuracy equal with the case controlled according to a reference signal with a high clock frequency when the electric power is converted is obtained according to a reference signal with a low clock frequency. The quantity of signal S3 of the time that corresponds to the difference of EO in the output voltage to reference voltage EREF by circuit 12 of the generation of quantity of signal of time is generated synchronizing with reference timing signal S1. The phase generates the class of the phase-shift signal of n piece for which only [Cycle of S0/]/n is late one by one by phase-shift signal generation circuit 13, counter circuit 14, and digital addition circuit 15, these numbers are counted respectively, and the count value of n piece is added. The control signal S5that corresponds to TON between when adding value ADD is input with decision circuit 16 of on time of the switch element and control signal generation circuit 17 and it turns it on is generated.

Abstract: Silicone surface-treated magnesium hydroxide which is surface treated by a silicone oil, the silicone oil comprising: a polyorganosiloxane containing a plurality of first siloxane units each of which contains hydrogen atom bonded silicon atom. The first siloxane units shares 50 mol % or less of total siloxane units in one molecule in average. Accordingly, sufficient fire retardancy and mechanical properties such as sufficient elongation are achieved.

Abstract: There are provided an analog-digital converter circuit capable of performing the same degree of operation as being performed at a high-frequency oscillation pulse using a low-frequency oscillation pulse without using the high-frequency oscillation pulse, a timing signal generating circuit generating a timing signal at the high frequency, and a control device using the circuits. In an analog-digital converter circuit, a periodic signal generating circuit allows the first to j-th pulse counting devices of the N pulse counting devices to count a count value X and allows the other pulse counting devices to count a count value X?1 in each sampling period by sequentially generating N serial periodic signals at a delay time interval of [approximate value of one period (T) of periodic signals]÷N. A digital signal generating circuit converts the analog signal to the digital signal.

Abstract: Provided is a therapeutic or prophylactic agent for generalized pain syndrome, for which no cause and therapies have been established. A therapeutic or prophylactic agent for generalized pain syndrome containing an LPA1 antagonist or autotaxin-inhibiting substance as an active ingredient. The pharmaceutical is preferably administered to the central nervous system. The generalized pain syndrome is preferably fibromyalgia, chronic fatigue syndrome or hypersensitivity colitis.

Abstract: A novel luminescent metal complex comprises a composition of [(PtII)2(AuI)2(MI)2(L)8] where MI denotes AgI or CuI, and L denotes a structure represented by the formula (1)

Abstract: A fermented tea produced by primary-drying tea material leaves by means of a primary tea rolling dryer (primary drying step) to adjust the moisture content of raw leaves (tea material leaves) of bancha with low qualities (the second crop of tea, the third crop of tea, the shuto-bancha, the skiffed leaves of tea, and the like) to a constant moisture; subsequently, providing them in a tea roller (tea rolling step); adding loquat leaves during the tea rolling step in order to knead loquat leaves together with the tea material leaves; and fermenting and drying the kneaded tea material leaves and loquat leaves. The fermented tea is formed into a composition having, as an active component, the fermented tea obtained by tea-rolling processing of tea material leaves and loquat leaves, and an extract contained in the fermented tea.

Abstract: The invention provides a method for evaluating a corneal disorder quantitatively and is applicable to living eyes. In particular, the invention provides a method for measuring a corneal transepithelial electric resistance, which method comprises: (1) a step of placing a first electrode on the cornea and a second electrode on the conjunctiva; and (2) a step of flowing an electric current between the first electrode and the second electrode to measure the electric resistance. The invention also provides a device for measuring a corneal transepithelial electric resistance value.

Abstract: There is provided a novel luminescent metal complex. A metal complex having a composition of [(PtII)2(MI)2(X)2(L)4(LH)2], where MI denotes AgI, AuI or CuI, X denotes Cl, Br or I, L denotes a structure represented by the formula (1), and LH denotes a structure represented by the formula (2).

Abstract: Disclosed is a metal complex containing a composition represented by the following formula (a). [(PdII)2(MI)2(X)2(L)4(L?)2] (In the formula (a), MI represents AgI, AuI or CuI; X represents Cl, Br or I; L represents a group represented by formula (1); L? represents a group represented by formula (2); two MIs may be the same as or different from each other; four Ls may be the same as or different from each other; and two L's may be the same as or different from each other.) (In the formulae (1) and (2), R1, R2 and R3 independently represent a hydrogen atom, a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted monovalent heterocyclic group.

Abstract: To detect a peak time of an exciting current of a transformer, a primary current corresponding to the peak time, or a variation time of the primary voltage, and to switch a switch after expiration of a predetermined period from the peak time, after the peak time occurs. A control apparatus 1 is applied to a power conversion circuit 2 which includes a switch circuit 23 including one switch or a plurality of switches and a transformer 21. The control apparatus includes: an output voltage detector 11 detecting a value of an output voltage of the power conversion circuit; an exciting current peak time generator 12 detecting a peak time of an exciting current of the transformer; a timing generator 13 generating a switching timing of the one switch or the plurality of switches. The timing generator 13 generates the switching timing of the one switch or the plurality of switches on the basis of the output voltage and the peak time.