Patents Assigned to Nagase & Co., Ltd.
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Publication number: 20220372537Abstract: The invention relates to a metabolic enzyme-disrupted aerobic strain and a method for culturing the strain. The present invention provides, for example, a culture comprising a culture medium that has been cultured under an aerobic condition, wherein the culture medium contains an aerobe, wherein the aerobe has a disrupted gene encoding a metabolic enzyme of glycolysis selected from the group consisting of the metabolic enzymes of glycolysis except hexokinase, thereby suppressing metabolism from a carbon source (e.g., glucose) to the TCA cycle in the aerobe.Type: ApplicationFiled: October 23, 2020Publication date: November 24, 2022Applicant: Nagase & Co., Ltd.Inventor: Shogo YAMAMOTO
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Publication number: 20200317720Abstract: The present invention provides a production method for a metal-encapsulated cage-like protein, comprising a step of introducing a metal element into a cage-like protein in the presence of a polysaccharide to produce a metal-encapsulated cage-like protein that encapsulates the metal element.Type: ApplicationFiled: June 26, 2017Publication date: October 8, 2020Applicant: Nagase & Co., Ltd.Inventor: Mami TANAKA
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Patent number: 10632881Abstract: An osmosis membrane is disposed at the boundary between a three-dimensional network structure section and a foam section. The osmosis membrane allows a liquid foam material to permeate. The three-dimensional network structure section is impregnated with the foam material through the osmosis membrane, and subsequently the foam material is solidified, thereby connecting the three-dimensional network structure section and the foam section to each other. The bonded body of the three-dimensional network structure section and the foam section is completed only by disposing the cushion structure component in between the upper mold and the lower mold, and performing a foaming step.Type: GrantFiled: April 14, 2015Date of Patent: April 28, 2020Assignee: Nagase & Co., Ltd.Inventors: Hajime Kitamoto, Takuya Nagase
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Patent number: 10202627Abstract: An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.Type: GrantFiled: February 28, 2017Date of Patent: February 12, 2019Assignees: The Kitasato Institute, Nagase & Co., Ltd.Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi
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Publication number: 20170043695Abstract: An osmosis membrane is disposed at the boundary between a three-dimensional network structure section and a foam section. The osmosis membrane allows a liquid foam material to permeate. The three-dimensional network structure section is impregnated with the foam material through the osmosis membrane, and subsequently the foam material is solidified, thereby connecting the three-dimensional network structure section and the foam section to each other. The bonded body of the three-dimensional network structure section and the foam section is completed only by disposing the cushion structure component in between the upper mold and the lower mold, and performing a foaming step.Type: ApplicationFiled: April 14, 2015Publication date: February 16, 2017Applicant: Nagase & Co., Ltd.Inventors: Hajime Kitamoto, Takuya Nagase
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Publication number: 20170043509Abstract: A three-dimensional network structure is impregnated with a foam material through an osmosis membrane. The foam material is then solidified. The foam material with which the three-dimensional network structure is impregnated is in contact with resin wires of the three-dimensional network on a wide area and is solidified. Thus, a bonded body that comprises the three-dimensional network structure and a foam and has improved connection strength can be manufactured.Type: ApplicationFiled: April 14, 2015Publication date: February 16, 2017Applicant: Nagase & Co., Ltd.Inventors: Hajime Kitamoto, Takuya Nagase, Takashi Koida
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Publication number: 20150247052Abstract: A coating comprising (1) calcium oxide and/or calcium hydroxide, (2) magnesium sulfate, (3) benzoic acid and/or a benzoate salt, and (4) a resin, wherein the coating comprises 0.1-30 parts by mass in total of the calcium oxide and calcium hydroxide, 0.05-15.0 parts by mass of the magnesium sulfate, and 0.01-10 parts by mass in total of the benzoic acid and the benzoate salts per 100 parts by mass of a total solid content in the coating.Type: ApplicationFiled: July 30, 2012Publication date: September 3, 2015Applicants: Nagase & Co., Ltd., Kyoto Materials Co. Ltd.Inventors: Masato Yamashita, Toyokazu Nomura
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Publication number: 20150181913Abstract: An enzyme preparation for suppressing bitterness of food contains phospholipase and, if necessary, further contains protease. A method for suppressing bitterness of food includes treating a food material with a food bitterness suppressor containing the enzyme preparation. A method for producing a processed food product includes treating a food material with a food bitterness suppressor containing the enzyme preparation. Food treated with the enzyme preparation for suppressing bitterness of food tastes less bitter even when cooked after long-term preservation. Furthermore, an enzyme preparation for suppressing bitterness of food and for, if necessary, tenderizing food can be provided.Type: ApplicationFiled: May 17, 2013Publication date: July 2, 2015Applicants: Nagase ChemteX Corporation, Nagase & Co., Ltd.Inventors: Yosuke Makino, Yukifumi Nishimoto
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Patent number: 8798512Abstract: A method for producing a printed material, a method for producing a dye-printed material, a printing apparatus, and a dye-printing system have a good transfer property when a dry toner including a dye is electrostatically transferred to a base material, such as a fabric, based on an electrophotographic system or the like. The methods include a step of providing at least one type of dry toner containing a dye component and a binder resin to a charged body, a step of transferring the dry toner from the charged body to a base material, and a step of fixing the dry toner on the base material. In the transfer step, an electric field is applied between the charged body and the base material to fly the dry toner on the charged body from the charged body to the base material.Type: GrantFiled: December 16, 2009Date of Patent: August 5, 2014Assignees: Nagase & Co., Ltd., Kyoto City, Hayami, TadashiInventors: Kazumi Okamoto, Tadashi Hayami
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Patent number: 8722919Abstract: The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of ?-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.Type: GrantFiled: July 28, 2006Date of Patent: May 13, 2014Assignee: Nagase & Co., Ltd.Inventors: Keiji Maruoka, Toru Inoue, Jun Matsumoto
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Patent number: 8716524Abstract: The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2?-dimethylene bromide-1,1?-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.Type: GrantFiled: March 3, 2011Date of Patent: May 6, 2014Assignee: Nagase & Co., LtdInventor: Keiji Maruoka
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Patent number: 8697910Abstract: The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2?-dimethylene bromide-1,1?-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.Type: GrantFiled: January 23, 2007Date of Patent: April 15, 2014Assignee: Nagase & Co., LtdInventor: Keiji Maruoka
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Patent number: 8614316Abstract: The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2?-dimethylene bromide-1,1?-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.Type: GrantFiled: March 24, 2006Date of Patent: December 24, 2013Assignee: Nagase & Co., Ltd.Inventors: Keiji Maruoka, Yukifumi Nishimoto, Kenichiro Yamamoto
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Patent number: 8263798Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an ?-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an ?-alkyl-?-amino acid and a derivative thereof as well as an ?,?-dialkyl-?-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.Type: GrantFiled: December 28, 2011Date of Patent: September 11, 2012Assignee: Nagase & Co., Ltd.Inventors: Keiji Maruoka, Kenichiro Yamamoto, Yukifumi Nishimoto
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Patent number: 8252952Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an ?-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an ?-alkyl-?-amino acid and a derivative thereof as well as an ?,?-dialkyl-?-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.Type: GrantFiled: December 28, 2011Date of Patent: August 28, 2012Assignee: Nagase & Co., Ltd.Inventors: Keiji Maruoka, Kenichiro Yamamoto, Yukifumi Nishimoto
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Patent number: 8242303Abstract: The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.Type: GrantFiled: May 19, 2008Date of Patent: August 14, 2012Assignee: Nagase & Co., Ltd.Inventors: Jun Matsumoto, Toru Inoue
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Patent number: 8110680Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an ?-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an ?-alkyl-?-amino acid and a derivative thereof as well as an ?,?-dialkyl-?-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.Type: GrantFiled: September 13, 2007Date of Patent: February 7, 2012Assignee: Nagase & Co., Ltd.Inventors: Keiji Maruoka, Kenichiro Yamamoto, Yukifumi Nishimoto
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Patent number: 8047887Abstract: A production method for an organic EL display comprises sticking an anti-static sheet 2 onto the first main surface of a glass substrate 11 on which a metal hat 13 is formed and etching the second main surface 11c of the glass substrate 11 stuck with the anti-static sheet 2.Type: GrantFiled: April 2, 2008Date of Patent: November 1, 2011Assignee: Nagase & Co., Ltd.Inventor: Yohei Mayuzumi
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Publication number: 20110190527Abstract: The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.Type: ApplicationFiled: May 19, 2008Publication date: August 4, 2011Applicant: Nagase & Co., Ltd.Inventors: Jun Matsumoto, Toru Inoue
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Patent number: 7928224Abstract: The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2?-dimethylene bromide-1,1?-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.Type: GrantFiled: January 27, 2005Date of Patent: April 19, 2011Assignee: Nagase & Co., LtdInventor: Keiji Maruoka