Patents Assigned to NaniRx, Inc.
  • Tat-Based Vaccine Compositions and Methods of Making and Using Same
    Publication number: 20120121636
    Abstract: A Tat-based vaccine composition comprising at least one antigen coupled to at least one immunostimulatory lentivirus trans-activator of transcription (Tat) molecule wherein the antigen is a cancer antigen an infectious disease antigen or a fragment thereof and methods to treat disease by administering the Tat-based vaccine composition. An additional Tat-based vaccine composition comprising immunostimulatory lentivirus Tat is provided.
    Type: Application
    Filed: January 20, 2012
    Publication date: May 17, 2012
    Applicant: NANIRX, INC.
    Inventor: David I. Cohen
  • TAT-BASED IMMUNOMODULATORY COMPOSITIONS AND METHODS FOR THEIR DISCOVERY AND USE
    Publication number: 20110195078
    Abstract: A method for identifying new immunomodulatory chemical entities (NICE) comprising reacting a candidate NICE with a Tat SH3 binding domain, identifying the bound candidate NICE and determining whether the candidate NICE induces monocytes to differentiate into dendritic cells (DC) or regulatory macrophages (AReg). In particular, the present invention relates to identifying NICE that are either immunostimulatory or immunosuppressive.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 11, 2011
    Applicant: NANIRX, INC.
    Inventor: David I. Cohen
  • Tat-based immunomodulatory compositions and methods of their discovery and use
    Patent number: 7927580
    Abstract: A method for identifying new immunomodulatory chemical entities (NICE) comprising reacting a candidate NICE with a Tat SH3 binding domain, identifying the bound candidate NICE and determining whether the candidate NICE induces monocytes to differentiate into dendritic cells (DC) or regulatory macrophages (AReg). In particular, the present invention relates to identifying NICE that are either immunostimulatory or immunosuppressive.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: April 19, 2011
    Assignee: NaniRx, Inc.
    Inventor: David I. Cohen