Abstract: A new-type papermaking wet-end defoamer and methods of making relating to the field of the chemical preparations for use in papermaking. The defoamer including 5˜99% FAME (fatty acid methyl ester) derivatives having a general structural formula of R1CO(EO)x(PO)yOCH3, molecular weight of 300˜3000 and a turbidity point of 20˜80° C.; which are the products of the addition reaction of FAME as an initiator and EO (ethylene oxide) and/or PO (propylene oxide) under the action of catalyst. The defoamer also including 0.1˜80% polyether having a general structural formula of R2{M(EO)m(PO)nH}a, a molecular weight of 500˜8000 and a turbidity point of 10˜80° C. The defoamer also including a 0.1˜70% modified polyether, with a general structural formula of R2{M(EO)m(PO)nR3}a. The defoamer also including 0.1˜20% natural oil and fat.