Patents Assigned to Nanjing University
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Publication number: 20110033371Abstract: A method for preparing titania or precursor thereof with a controllable structure from micropore to mesopore is provided. The method is characterized in that the alkali metal titanate as raw material is reacted for 0.5˜72 hours in the wet atmosphere with humidity of 2˜100% at temperature of 20˜250° C., then washed with water or acid, finally performed by air roasting or solvent thermal treatment. The method has advantages that the raw material is easy to be obtained, the conditions and preparation are controllable, the pore structure may be adjusted from micropore to mesopore, crystal mixing and doping are easy, reacting time is short, preparing cost is low, and the said method is suitable for large scale production and so on. The most probable aperture of titanium oxide or precursor thereof with a controllable structure from micropore to mesopore is in the range of 1˜20 nm, the pore volume thereof is in the range of 0.05˜0.4 cm3/g, and the specific surface area thereof is more than 30 m2/g.Type: ApplicationFiled: August 7, 2007Publication date: February 10, 2011Applicants: NANJING UNIVERSITY OF TECHNOLOGY, NANJING TAIWEI TECHNOLOGY CO., LTD.Inventors: Xiaohua Lu, Yaxin Zhou, Chang Liu, Xin Feng, Zhuhong Yang, Changsong Wang
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Patent number: 7873089Abstract: Using sampled Bragg grating structure, the present invention proposes a distributed feedback (DFB) semiconductor laser based on reconstruction-equivalent-chirp technology. Namely, the Bragg grating in the said DFB semiconductor laser cavity is a sampled Bragg grating, in which there is an equivalent grating corresponding to the original ordinary DFB grating as feedback for lasing. The laser wavelength of the said semiconductor laser located within the operation bandwidth of the said equivalent grating. The said equivalent grating is designed and fabricated using REC technology and has equivalent chirps, one equivalent phase shift or multiple equivalent phase shifts. The said sampled Bragg grating has multiple ghost gratings and the wavelength spacing between neighboring ghost gratings is inversely proportional to the sampling period and the effective refractive index of the said semiconductor laser.Type: GrantFiled: February 25, 2007Date of Patent: January 18, 2011Assignee: Nanjing UniversityInventor: Xiangfei Chen
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Publication number: 20100311948Abstract: Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of ?V?3 and ?V?5 and a linking peptide. Also provided are the expression method and simple separation and purification process for the production of the fusion protein which is soluble and has high content of the polymer, and use of the fusion protein for the manufacturing of a medicament for the treatment of tumor. The fusion protein has good tumor tissue targeting property, significantly enhanced anti-tumor effect, which can also reduce the dose of the needed protein for the target treatment effect, improve the bioavailability, reduce the treatment cost, decrease and overcome the potential toxic and side effects of the tumor necrosis factor-related apoptosis inducing ligand.Type: ApplicationFiled: October 8, 2008Publication date: December 9, 2010Applicant: NANJING UNIVERSITYInventors: Zichun Hua, Lin Cao
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Publication number: 20100288190Abstract: A kind of growth method of non-polarized-plane InN which is growing m-plane InN and In-rich m-plane InGaN on LiA1O2 (100) substrate by the metal organic chemical vapor deposition (MOCVD), and m-plane is one kind of non-polarized-plane, In-rich denotes that the component of In x is higher than 0.3 in InxGa1?xN. The invention synthetically grows m-plane InN and In-rich m-plane InGaN using LiA1O2 (100) as substrate which will be disposed and the buffer by MOCVD. And the non-polarized-plane InN would be produced through choosing appropriate substrate and the technique condition of growth as well as using the design of buffer by MOCVD.Type: ApplicationFiled: March 28, 2010Publication date: November 18, 2010Applicant: NANJING UNIVERSITYInventors: RONG ZHANG, ZILI XIE, BIN LIU, XIANGQIAN XIU, HONG ZHAO, XUEMEI HUA, PING HAN, DEYI FU, YI SHI, YOUDOU ZHENG
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Publication number: 20100292594Abstract: The present disclosure provides an HRV analysis-based method of lie detection, related computer program product, computer readable storage medium and system. Also provided is a method of HRV analysis using strange entropy.Type: ApplicationFiled: May 15, 2009Publication date: November 18, 2010Applicant: Nanjing UniversityInventor: Xinbao NING
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Publication number: 20100109203Abstract: The present invention provides a flexible nanoimprint mold which can fabricate sub-15 nm ultra fine structures on either planar or curved substrates. The mold comprises a top ultra-thin rigid layer of imprint patterning features and a bottom thick flexible layer of polymer elastomer. The two distinct layers are preferably integrated via chemically bonding. The top layer of the mold enables a sub-15 nm resolution of pattern fabrication and the bottom layer affords a conformal contact to planar or curved surface of substrates. The methods for fabricating the same are disclosed.Type: ApplicationFiled: February 26, 2009Publication date: May 6, 2010Applicant: NANJING UNIVERSITYInventors: Yanfeng Chen, Haixiong Ge, Zhiwei Li, Changsheng Yuan, Minghui Lu
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Publication number: 20100062142Abstract: A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a cover; (2) removing tips of the template and cover to form an opening in the cover; and (3) removing the template of the first material to obtain hollow microneedles of the second material. This simple, efficient and cost-effective fabrication method can mass produce hollow microneedle arrays involving no complicated and expensive equipments or techniques, which can be used in commercial fabrication of hollow needles for delivering drugs or genes across or into skin or other tissue barriers with advantages of minimal damage, painless, long-term and continuous usages.Type: ApplicationFiled: January 5, 2009Publication date: March 11, 2010Applicant: NANJING UNIVERSITYInventors: Mingwei Zhu, Yanfeng Chen, Zhenlin Wang, Yanqing Lu, Haixiong Ge, Yuefeng Tang
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Publication number: 20100051813Abstract: A measurement accessory with multiple transmission-reflections uses for an infrared spectrometer, laid accessory is arranged in the sample cavity of the infrared spectrometer. Said accessory includes two parallel plane mirrors (7, 8) and a sample holder fixed between the two mirrors (7, 8). Said sample holder can fix the sample piece (9) between the two plane mirrors (7, 8) and make the sample piece parallel with plane mirrors (7, 8). During measuring, the infrared ray emitted from infrared spectrometer (17) forms a certain angle incident to the space between said plane mirrors and reflects for several times between the two parallel plane mirrors (7, 8) and the sample piece (9) is measured with multiple transmission-reflections by the infrared spectrometer. Then the infrared spectrometer (20) enters into the detector of infrared spectrometer.Type: ApplicationFiled: November 12, 2007Publication date: March 4, 2010Applicant: NANJING UNIVERSITYInventors: Shoujun Xiao, Hongbo Liu
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Publication number: 20100041544Abstract: Electrode catalyst of carbon nitride nanotubes supported by platinum and ruthenium nanoparticles have been produced by a simple, rapid, effective and green process: taking use of the affinity of carbon nitride nanotubes to platinum and ruthenium atoms, Pt and Ru nanoparticles could be directly deposited on carbon nitride nanotubes by the reduction reaction, hereby avoiding the pre-activation or modification process needed by carbon nanotubes. The electrode catalysts produced in this way are suitable for proton exchange membrane fuel cells or direct methanol fuel cells, as well as other chemical reactions catalyzed by Pt and Ru.Type: ApplicationFiled: May 12, 2008Publication date: February 18, 2010Applicant: NANJING UNIVERSITYInventors: Zheng Hu, Yanwen Ma, Bing Yue, Leshu Yu
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Publication number: 20090289007Abstract: A method for the treatment of waste water from florfenicol production is provided, which mainly comprises the steps as follows: adding iron chips or steel slag to waste water from a copper salt workshop, regulating the pH value, filtering, then adding limestone, lime or Ca(OH)2 and having a solid-liquid separation; blending the treated waste water and waste water from a splitting workshop, oxidizing the residual reductive matter by ozone and removing NH3-N by blowing; blending the treated water and waste water from esterifying or florfenicol workshops and diluting the blended water, adding phosphate and microelement, regulating the pH value, then having an anaerobic treatment in an anaerobic reactor; diluting the treated waste water, then having an aerobic treatment in an aerobic reactor.Type: ApplicationFiled: November 28, 2006Publication date: November 26, 2009Applicant: NANJING UNIVERSITYInventors: Hongqiang Ren, Lili Ding, Bingqing Xin
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Patent number: 7621046Abstract: A molding process of composite material including high-thermal-conductor and room-temperature magnetic refrigerant comprises the steps of nesting magnetic refrigerant with high-thermal-conductor and connecting them mutually, especially making the room-temperature magnetic-thermal-conductor into sheet, strip or filament, inserting the high-thermal-conductors'sheet, strip or filament in the room-temperature magnetic refrigerant's sheet or filament and connecting them fully. This invention has solved the application of the room-temperature magnetic-thermal-conductor, particularly the application of the room-temperature magnetic-thermal-conductor which is lower thermal-conductor, easier oxidation and powdering. The invention utilizes the high thermal-conductor to solve the problem of room-temperature magnetic refrigerant which is poor in conventional heat exchange, meanwhile decreases the loss of the magnetic-thermal effect.Type: GrantFiled: June 30, 2003Date of Patent: November 24, 2009Assignee: Nanjing UniversityInventor: Dingwei Lu
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Patent number: 7473799Abstract: A process for the preparation of disubstituted adamantine derivatives characterized by the factor that the aromatic receptors can be a series of halide anisole, phenol, toluene, naphthalene, thiophene, or furan and their substituted derivatives. The synthesized disubstituted adamantine derivatives were subsequently converted into a new class of synthetic retinoids of pharmaceutical importance.Type: GrantFiled: January 29, 2007Date of Patent: January 6, 2009Assignee: Nanjing University of Aeronautics and AstronauticsInventors: Liqin Chen, Lei Tian, Xiaoquan Yao
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Publication number: 20080306248Abstract: Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided. The biomacromolecule is selected from apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, EGF, folacin acid or transcobalamin, and the bioreductive agent is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal compound. Such conjugate can selectively target the tumor cells, and lower the toxicity of medicines and survivability of tumor cells, so that the conjugate can be used for delivery of anti-tumor compounds or treating tumors.Type: ApplicationFiled: March 31, 2006Publication date: December 11, 2008Applicant: NANJING UNIVERSITYInventors: Yiqiao Hu, Jinhui Wu, Lin Wu, Lingying Luo, Feng Zhi
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Patent number: 7056732Abstract: The present invention relates to the field of biotechnology. The invention provides a novel approach using tobacco mosaic virus omega leader sequence to enhance the solubility of the recombinant products in E. coli and the method of use therefore. The invention provides the utilization of tobacco mosaic virus omega leader sequence into E. coli expression vector, and the tobacco mosaic virus omega leader sequence containing expression vector can be used in combination with other available means to obtain higher expression or better solubility. The invention can be applied to biotechnological pharmaceutical industry, genetic engineering, biochemistry and molecular biology etc. The invention provides an expression vector pTORG, which is a highly efficient GST fusion expression vector, and can significantly enhance the yield of biologically active recombinant products.Type: GrantFiled: September 4, 2002Date of Patent: June 6, 2006Assignee: Nanjing UniversityInventors: Zichun Hua, Hongxia Zhang
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Patent number: 7022639Abstract: The present invention provides a catalytic activity accelerant. The accelerant is added to stock oil for increasing the catalyst activity, the depth of catalytic hydrogenation and the yield of catalytic hydrogenation product, degrading the reaction conditions of catalytic hydrogenation, and improving the quality of product. The catalytic activity accelerant is consisted of an alkyl succinimide derivative, an alkyl phenol and a surfactant. The amount of the alkyl succinimide derivative in the accelerant is 5-70 wt. %. The amount of the alkyl phenol in the accelerant is 2-70 wt. %. The amount of the surfactant in the accelerant is 2-70 wt. %.Type: GrantFiled: September 7, 2001Date of Patent: April 4, 2006Assignee: Nanjing University of TechnologyInventors: Jintang Wang, Jianning Guan, Houliang Dai, Lijin Zhou, Minghui Tang, Yuming Zhang, Pingkai Ouyang, Chengfeng Li, Chaorong Dai, Jingyi Wang
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Publication number: 20050066269Abstract: A method and apparatus for identifying coherent areas within a Web page. First, a Web page is parsed into an HTML DOM tree and an HTML tag token stream. Next, repeated-patterns are induced from the Web page. After filtering out improper repeated-patterns and generating corresponding instances of the repeated-patterns, the repeated-patterns are mapped back to corresponding regions in the Web page. Based on the mappings, a hierarchical RST tree containing information blocks is generated. Information items within the information blocks are detected then used to generate a hierarchical structural information block tree. Information blocks from the structural information block tree are then classified into text information blocks and link information blocks. Based on the classification and block semantic similarity, the bocks are clustered then grouped into semantic information blocks. The semantic information blocks contain main text information blocks and related link blocks which, if necessary, can be labeled.Type: ApplicationFiled: September 17, 2004Publication date: March 24, 2005Applicants: Fujitsu Limited, Nanjing UniversityInventors: Jun Wang, Jicheng Wang, Gangshan Wu, Hiroshi Tsuda
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Patent number: 6734212Abstract: The invention relates to compositions and methods for treating or preventing disease or disorders caused by or associated with certain bacterial infection, especially Escherichia coli (E. coli) or Helicobacter pylori (H. pylori) infection. One exemplary compound of the present invention has the following formula I: wherein n is 0 or 1, and R is selected from the group consisting of C1-10 alkyl, C6-10 aryl and and wherein when n is 0, R is not C6-10 aryl.Type: GrantFiled: October 10, 2001Date of Patent: May 11, 2004Assignees: Shanghai East Best Biopharmaceutical, Nanjing UniversityInventors: Dexu Zhu, Mitsumi Muramatsu, Jianshu Xie, Cheng Ni, Ming-Wei Wang
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Patent number: 6714569Abstract: The design of a special type of optical superlattice and its application in the all-solid state laser is involved in this invention. Nd ions doped laser crystal in common use can radiate three relatively intense spectral lines when excited: the first wavelength is around 900 nm; the second wavelength is around 1064 nm; the third wavelength is around 1300 nm, whose accurate wavelength are depended on their host crystal (for example, to Nd:YAG, they are 946 nm, 1064 nm and 1319 nm, respectively). On the other hand, for LiNbO3 (LN), LiTaO3 (LT), KTP and other ferroelectric crystals, the positive and negative 180° ferroelectric domains in these crystals can be arranged orderly according to certain sequence via crystal growth, electric field poling, and other state-of-the-art domain reversion technique, forming superlattice that is applicable to quasi-phase-matching (QPM) laser frequency conversion.Type: GrantFiled: January 3, 2002Date of Patent: March 30, 2004Assignee: Nanjing UniversityInventors: Shining Zhu, Jingliang He, Yongyuan Zhu, Huitian Wang, Guozheng Ruo, Chao Zhang, Yiqiang Qin, Naiben Ming
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Publication number: 20030104628Abstract: The present invention relates to the field of biotechnology. The invention provides a novel approach using tobacco mosaic virus omega leader sequence to enhance the solubility of the recombinant products in E. coli and the method of use therefore. The invention provides the utilization of tobacco mosaic virus omega leader sequence into E. coli expression vector, and the tobacco mosaic virus omega leader sequence containing expression vector can be used in combination with other available means to obtain higher expression or better solubility. The invention can be applied to biotechnological pharmaceutical industry, genetic engineering, biochemistry and molecular biology etc. The invention provides an expression vector pTORG, which is a highly efficient GST fusion expression vector, and can significantly enhance the yield of biologically active recombinant products.Type: ApplicationFiled: September 4, 2002Publication date: June 5, 2003Applicant: Nanjing UniversityInventors: Zichun Hua, Hongxia Zhang