Abstract: A composition is provided. The composition comprises a plurality of spherical particles composed of a whole cell membrane fraction, wherein the spherical particles exhibit native membrane symmetry and expression of native markers and wherein the plurality of spherical particles encapsulate a conjugate comprising a water insoluble drug linked to a cell penetrating peptide (CPP). Also provided are methods of producing and using the composition.
Abstract: A method of producing spherical particles is provided herein. Also provided are compositions generated thereby and uses thereof in disease diagnosis and treatment.
Type:
Application
Filed:
June 12, 2022
Publication date:
August 22, 2024
Applicants:
Nano Ghost Ltd, Technion Research & Development Foundation Limited
Inventors:
Osnat BOHANA-KASHTAN, Oded PINKAS, Irina GOTLIV, Haim TSUBERY, Tal Yoetz KOPELMAN, Neta CHAIM, Noa AVNI, Hanna LIANDRES, Roy GOVRIN, Yonatan MALCA, Marcelle MACHLUF, Orit AMSALEM-BERGELSON