Patents Assigned to NANOH
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Publication number: 20230109283Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: ApplicationFiled: October 4, 2022Publication date: April 6, 2023Applicants: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
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Patent number: 11497818Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: GrantFiled: May 23, 2018Date of Patent: November 15, 2022Assignees: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Patent number: 10987435Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.Type: GrantFiled: August 15, 2017Date of Patent: April 27, 2021Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, NANOHInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Patent number: 10252473Abstract: Provided is a compression bar apparatus for applying pressure to desired areas of a thin film composite (TFC) membrane, such as spiral wound TFC membranes and elements, including membranes and elements used for nanofiltration, reverse osmosis or forward osmosis to purify water, such as tap water, seawater, and brackish water. Application of pressure to a spiral wound element by the apparatus produces a membrane with increased sealant penetration, reduced osmotic blistering, and minimal damage to the active area of the membrane. Also provided are methods of using the apparatus.Type: GrantFiled: August 31, 2015Date of Patent: April 9, 2019Assignee: LG NANOH2O, INC.Inventors: Hoang T. Nguyen, Pouya Dehghani
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Patent number: 10155203Abstract: Provided is a post-formation process for preparation of a highly permeable thin film composite membranes for reverse osmosis, particularly for use with brackish water at low energy conditions. The process includes contacting a polyamide discrimination layer of a TFC membrane with a solution containing an oxidizing agent to form a treated membrane, followed by contacting the treated membrane with a solution containing a reducing agent. The resulting membrane exhibits enhanced water flux while maintaining salt rejection. Also provided are reverse osmosis membranes prepared in accord with the method, and modules containing the highly permeable thin film composite membranes, and methods of purifying water using the membranes or modules.Type: GrantFiled: March 3, 2016Date of Patent: December 18, 2018Assignees: LG NANOH2O, INC., LG CHEM, LTD.Inventors: Keunwon Song, Young Hoon Ko, Evgueni Rozenbaoum, Chongkyu Shin
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Publication number: 20180264145Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: ApplicationFiled: May 23, 2018Publication date: September 20, 2018Applicants: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
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Patent number: 10010833Abstract: A spiral wound module in which the membrane sheet is heat and pressure treated to collapse at least some of the pores of the support layer. The treated membrane can then be folded along the heat and pressure treated area to form a crease. Once folded, the membrane sheet can be wound around a perforated inner tube along with a feed channel spacer and a permeate collection sheet. The wound module can then be enclosed into a hard shell with anti-telescoping devices at each end. By collapsing at least some of the pores in the support layer, the membrane becomes less permeable to fluid in the treated area. As such, there will be less or no leakage of unfiltered fluid passing through the fold line of the membrane sheet during operation of the wound module.Type: GrantFiled: February 18, 2015Date of Patent: July 3, 2018Assignee: LG NANOH2O, INC.Inventors: Evgueni Rozenbaoum, Ales Devenica
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Patent number: 9795925Abstract: A membrane separation unit can include a cartridge, at least one membrane disposed within the cartridge, at least one seal plate, and a sealing ring seated in an outer groove of the seal plate. The at least one seal plate can seal one end of the cartridge. The seal plate can have at least one venting hole that forms a passage between the interior of the cartridge and the outer groove. The sealing ring can have a cross-sectional shape that forms a circular venting path between the sealing ring and the seal plate. The sealing ring can include one or more grooves to allow fluid to vent into an annular space between a device housing and the membrane separation unit. The sealing ring can include an outer surface having, in cross-section, two flattened surfaces that form an angle of between 90° and 175° there between.Type: GrantFiled: August 31, 2012Date of Patent: October 24, 2017Assignee: LG NANOH20, INC.Inventors: Frederick K. Lesan, Nicholas Kordani
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Patent number: 9744499Abstract: Reverse osmosis membranes made by interfacial polymerization of a monomer in a nonpolar (e.g. organic) phase together with a monomer in a polar (e.g. aqueous) phase on a porous support membrane. Interfacial polymerization process is disclosed for preparing a highly permeable RO membrane, comprising: contacting on a porous support membrane, a) a first solution containing 1,3-diaminobenzene, and b) a second solution containing trimesoyl chloride, wherein at least one of solutions a) and b) contains nanoparticles when said solutions are first contacted, and recovering a highly permeable RO membrane.Type: GrantFiled: October 8, 2015Date of Patent: August 29, 2017Assignee: LG NANOH2O, INC.Inventors: Christopher James Kurth, Jeffrey Alan Koehler, Meijuan Zhou, Brett Anderson Holmberg, Robert Leon Burk
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Patent number: 9737859Abstract: Provided is a process for preparation of a highly permeable thin film composite membranes for nanofiltration, reverse osmosis, and forward osmosis, particularly for reverse osmosis of brackish water. The process includes treating a prepared TFC membrane containing a discrimination layer on a frontside, a support layer, and a felt layer on the backside by contacting the backside of TFC membrane with a solution containing a pore protection agent that includes a tertiary amine salt of camphorsulfonic acid prior to or at the same time as contacting the frontside of the membrane with a solution containing a coating agent and drying the membrane. Also provided are reverse osmosis membranes prepared in accord with the method, and modules containing the highly permeable thin film composite membranes.Type: GrantFiled: January 11, 2016Date of Patent: August 22, 2017Assignees: LG NANOH2O, INC., LG CHEM, LTD.Inventors: Brett Anderson Holmberg, Jeff Koehler, Hyung Joon Jeon
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Patent number: 9731985Abstract: Provided is an interfacial polymerization process for preparation of a highly permeable thin film composite membrane, which can be used for nanofiltration, forward osmosis, or reverse osmosis, particularly for use with brackish water at low energy conditions. The process includes contacting a porous support membrane with an aqueous phase containing a polyamine and a flux enhancing combination of additives that includes a metal chelate additive containing a bidentate ligand and a metal atom or metal ion and a phosphoramide to form a coated support membrane, and applying an organic phase containing a polyfunctional acid halide to the coated support membrane to interfacially polymerize the polyamine and the polyfunctional acid halide to form a discrimination layer of the thin film composite membrane. Also provided are the membranes prepared by the methods and reverse osmosis modules containing the membranes.Type: GrantFiled: June 3, 2015Date of Patent: August 15, 2017Assignee: LG NANOH2O, INC.Inventors: Jeff Koehler, Alexis Foster, Keunwon Song, Young Ju Lee, Chongkyu Shin
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Patent number: 9724651Abstract: Provided are flux enhancing inclusion complexes for preparing highly permeable thin film composite membranes, and processes that include adding the flux enhancing inclusion complexes to the organic phase or aqueous phase prior to interfacial polymerization of the thin film composite membrane. The thin film composite membranes are suitable for nanofiltration, and reverse and forward osmosis. The provided processes can include contacting a porous support membrane with an aqueous phase containing a polyamine to form a coated support membrane, and applying an organic phase containing a polyfunctional acid halide and a flux enhancing inclusion complex to the coated support membrane to interfacially polymerize the polyamine and the polyfunctional acid halide to form a discrimination layer to form thin film composite membranes.Type: GrantFiled: July 14, 2015Date of Patent: August 8, 2017Assignees: LG NANOH2O, INC., LG CHEM, LTD.Inventors: Hyung Joon Jeon, Jeff Koehler, Hyungsam Choi
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Patent number: 9695065Abstract: Provided is an interfacial polymerization process for preparation of a highly permeable thin film composite membrane, which can be used for nanofiltration, or forward or reverse osmosis, for use with tap water, seawater and brackish water, particularly for use with brackish water at low energy conditions. The process includes contacting a porous support membrane with an aqueous phase containing a polyamine and a flux enhancing combination, which includes a metal chelate additive containing a bidentate ligand and a metal atom or metal ion and a dialkyl sulfoxide, to form a coated support membrane, and applying an organic phase containing a polyfunctional acid halide to the coated support membrane to interfacially polymerize the polyamine and the polyfunctional acid halide to form a discrimination layer of the thin film composite membrane. Also provided are the membranes prepared by the methods and reverse osmosis modules containing the membranes.Type: GrantFiled: June 3, 2015Date of Patent: July 4, 2017Assignee: LG NANOH2O, INC.Inventors: Jeff Koehler, Alexis Foster, Keunwon Song, Young Ju Lee, Chongkyu Shin
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Patent number: 9687792Abstract: Provided is an interfacial polymerization process for preparation of a highly permeable thin film composite membrane, which can be used for nanofiltration, forward osmosis, or reverse osmosis, particularly for use with brackish water or seawater. The process includes contacting a porous support membrane with an aqueous phase containing a polyamine to form a coated support membrane, and applying an organic phase containing a polyfunctional acid halide to the coated support membrane to interfacially polymerize the polyamine and the polyfunctional acid halide to form a discrimination layer of a thin film composite membrane, where the aqueous and/or organic phases include a flux-enhancing additive and a boron rejection-enhancing additive that includes a biguanide compound, dicarbonate compound, pentathiodicarbonate compound, or salts thereof. Also provided are the membranes prepared by the methods and reverse osmosis modules containing the membranes.Type: GrantFiled: August 31, 2015Date of Patent: June 27, 2017Assignees: LG CHEM, LTD., LG NANOH2O, INC.Inventors: Alberto Goenaga, Brett Anderson Holmberg, Andrew Ford, Amit Sankhe, Christopher Kurth, Robert Burk, Jin Kuk Lee, Jeff Koehler, Sung Yeol Choi, Youngsik Eom, Hyungsam Choi
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Patent number: 9597642Abstract: A process for preparing a reverse osmosis membrane that includes: (A) providing a polyamine, a polyfunctional acid halide, and a flux increasing additive having the formula Z+B?, where Z+ is an easily dissociable cation and B? is a beta-diketonate; (B) combining the polyamine, polyfunctional acid halide, and flux increasing additive on the surface of a porous support membrane; and (C) interfacially polymerizing the polyamine and the polyfunctional acid halide, and flux increasing additive on the surface of the porous support membrane to form a reverse osmosis membrane comprising (i) the porous support membrane and (ii) a discrimination layer comprising a polyamide. The reverse osmosis membrane is characterized by a flux that is greater than the flux of the same membrane prepared in the absence of the flux increasing additive.Type: GrantFiled: July 23, 2014Date of Patent: March 21, 2017Assignee: LG NANOH2O, INC.Inventors: Jeffrey Alan Koehler, Christopher James Kurth
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Patent number: 9254465Abstract: Reverse osmosis membranes made by interfacial polymerization of a monomer in a nonpolar (e.g. organic) phase together with a monomer in a polar (e.g. aqueous) phase on a porous support membrane. Interfacial polymerization process is disclosed for preparing a highly permeable RO membrane, comprising: contacting on a porous support membrane, a) a first solution containing 1,3-diaminobenzene, and b) a second solution containing trimesoyl chloride, wherein at least one of solutions a) and b) contains nanoparticles when said solutions are first contacted, and recovering a highly permeable RO membrane.Type: GrantFiled: June 16, 2014Date of Patent: February 9, 2016Assignee: LG NANOH2O, INC.Inventors: Christopher James Kurth, Jeffrey Alan Koehler, Meijuan Zhou, Brett Anderson Holmberg, Robert Leon Burk
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Publication number: 20140353239Abstract: A membrane separation unit can include a cartridge, at least one membrane disposed within the cartridge, at least one seal plate, and a sealing ring seated in an outer groove of the seal plate. The at least one seal plate can seal one end of the cartridge. The seal plate can have at least one venting hole that forms a passage between the interior of the cartridge and the outer groove. The sealing ring can have a cross-sectional shape that forms a circular venting path between the sealing ring and the seal plate. The sealing ring can include one or more grooves to allow fluid to vent into an annular space between a device housing and the membrane separation unit. The sealing ring can include an outer surface having, in cross-section, two flattened surfaces that form an angle of between 90° and 175° there between.Type: ApplicationFiled: August 31, 2012Publication date: December 4, 2014Applicant: NANOH2O, INC.Inventors: Frederick K. Lesan, Nicholas Kordani
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Patent number: 8801935Abstract: A process for preparing a reverse osmosis membrane that includes: (A) providing a polyamine, a polyfunctional acid halide, and a flux increasing additive having the formula Z+B? where Z+ is an easily dissociable cation and B? is a beta-diketonate; (B) combining the polyamine, polyfunctional acid halide, and flux increasing additive on the surface of a porous support membrane; and (C) interfacially polymerizing the polyamine and the polyfunctional acid halide, and flux increasing additive on the surface of the porous support membrane to form a reverse osmosis membrane comprising (i) the porous support membrane and (ii) a discrimination layer comprising a polyamide. The reverse osmosis membrane is characterized by a flux that is greater than the flux of the same membrane prepared in the absence of the flux increasing additive.Type: GrantFiled: November 10, 2011Date of Patent: August 12, 2014Assignee: NanoH2O, Inc.Inventors: Jeffrey Alan Koehler, Christopher James Kurth
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Publication number: 20140050846Abstract: Reverse osmosis membranes made by interfacial polymerization of a monomer in a nonpolar (e.g. organic) phase together with a monomer in a polar (e.g. aqueous) phase on a porous support membrane. Interfacial polymerization process is disclosed for preparing a highly permeable RO membrane, comprising: contacting on a porous support membrane, a) a first solution containing 1,3-diaminobenzene, and b) a second solution containing trimesoyl chloride, wherein at least one of solutions a) and b) contains nanoparticles when said solutions are first contacted, and recovering a highly permeable RO membrane.Type: ApplicationFiled: October 28, 2013Publication date: February 20, 2014Applicant: NanoH2O, Inc.Inventors: Christopher James Kurth, Jeffrey Alan Koehler, Meijuan Zhou, Brett Anderson Holmberg, Robert Leon Burk
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Patent number: 8603340Abstract: A process for preparing a reverse osmosis membrane that includes (A) providing a polyamine, a polyfunctional acid halide, and mono-hydrolyzed trimesoyl chloride; (B) combining the polyamine, polyfunctional acid halide, and mono-hydrolyzed trimesoyl chloride on the surface of a porous support membrane; and (C) interfacially polymerizing the polyamine and the polyfunctional acyl halide on the surface of the porous support membrane to form a reverse osmosis membrane comprising (i) the porous support membrane and (ii) a discrimination layer comprising a polyamide. The reverse osmosis membrane is characterized by a flux that is greater than the flux of the same membrane prepared in the absence of the mono-hydrolyzed trimesoyl chloride.Type: GrantFiled: April 30, 2012Date of Patent: December 10, 2013Assignee: NanoH2O, Inc.Inventors: Christopher James Kurth, Jeffrey Alan Koehler, Meijuan Zhou, Brett Anderson Holmberg, Robert Leon Burk