Patents Assigned to Nanocarrier Co., Ltd.
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Patent number: 8574601Abstract: A pharmaceutical composition containing a drug encapsulated in a polymer micelle composition containing a first block copolymer having affinity with HDL and a second block copolymer having affinity with a lipoprotein excluding HDL, each block copolymer having a hydrophobic polymer chain segment and a hydrophilic polymer chain segment such that a plurality of block copolymers arrange radially with the hydrophobic segments directed inward and the hydrophilic segments directed outward. In the composition, a detachment of the first block copolymer is induced by HDL adhesion which forms a gap and promotes the release of a drug encapsulated, while the second block copolymer excluding an affinity with HDL controls a release speed of the drug encapsulated.Type: GrantFiled: February 7, 2011Date of Patent: November 5, 2013Assignee: Nanocarrier Co., Ltd.Inventors: Yasuki Kato, Mitsunori Harada, Miho Ohuchi
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Patent number: 8519051Abstract: The present invention provides a block copolymer for a drug conjugate which comprises a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain.Type: GrantFiled: October 19, 2007Date of Patent: August 27, 2013Assignee: Nanocarrier Co., Ltd.Inventors: IuIian Bobe, Naoya Shibata, Hiroyuki Saito, Mitsunori Harada
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Patent number: 8436044Abstract: A pharmaceutical composition or combination drug, which contains, as active ingredients, (a) a coordination compound composed of a block copolymer represented by the following formula I or formula II and cisplatin, and (b) gemcitabine hydrochloride. In the formulae I and II, R1, A, R2, R3, m and n are as defined in the description.Type: GrantFiled: January 13, 2009Date of Patent: May 7, 2013Assignee: Nanocarrier Co., Ltd.Inventors: Mitsunori Harada, Iulian Bobe, Takashi Shimizu
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Publication number: 20120149649Abstract: The present invention provides a cationic polyamino acid suitable for a carrier that can form a stable complex with a nucleic acid under a physiological condition and release the nucleic acid in cells suitably. The cationic polyamino acid can associate with a nucleic acid and includes a cationic amino acid residue having a cationic group in a side chain and a hydrophobic amino acid residue having a hydrophobic group in a side chain. The cationic polyamino acid includes 1 to 20 units of the cationic amino acid residue and is represented by the following formula (1). The meaning of each symbol in the formula is as shown in the description.Type: ApplicationFiled: February 23, 2011Publication date: June 14, 2012Applicants: THE UNIVERSITY OF TOKYO, NANOCARRIER CO., LTD.Inventors: Yasuki Kato, Atsushi Ishii, Naoya Shibata, Tatsuyuki Hayashi, Kazunori Kataoka, Kanjiro Miyata, Nobuhiro Nishiyama
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Publication number: 20120093881Abstract: A pharmaceutical composition containing a drug encapsulated in a polymer micelle composition containing a first block copolymer having affinity with HDL and a second block copolymer having affinity with a lipoprotein excluding HDL, each block copolymer having a hydrophobic polymer chain segment and a hydrophilic polymer chain segment such that a plurality of block copolymers arrange radially with the hydrophobic segments directed inward and the hydrophilic segments directed outward. In the composition, a detachment of the first block copolymer is induced by HDL adhesion which forms a gap and promotes the release of a drug encapsulated, while the second block copolymer excluding an affinity with HDL controls a release speed of the drug encapsulated.Type: ApplicationFiled: February 7, 2011Publication date: April 19, 2012Applicant: NanoCarrier Co., Ltd.Inventors: Yasuki Kato, Mitsunori Harada, Miho Ohuchi
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Patent number: 8147868Abstract: The invention provides a physiologically active polypeptide- or protein-encapsulating polymer micelle composition derived from a block copolymer comprising hydrophilic segments and hydrophobic segments.Type: GrantFiled: April 25, 2007Date of Patent: April 3, 2012Assignee: Nanocarrier Co., Ltd.Inventors: Miho Ohuchi, Mitsunori Harada, Yuko Amano, Yasuki Kato
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Publication number: 20100221320Abstract: The present invention provides an active targeting polymer micelle encapsulating a drug, preventing an inappropriate release of a drug which may damage a normal cell. A polymer micelle 100 includes a backbone polymer unit 10 that has a target binding site 11 and a backbone polymer unit 20 that has a drug 14 and is free from the target binding site 11, such polymer units 10 and 20 being disposed in a radial arrangement in a state where the target binding site 11 is directed outward and the drug 14 is directed inward, in which: i) when the micelle is bound to a target 40 while maintaining the radial arrangement, the micelle is taken up into a cell 50 supplying the target 40 through endocytosis, and the drug 14 is released into the cell 50 by collapse of the radial arrangement in the cell 50; and ii) when the radial arrangement collapses in blood 60 before the micelle is bound to a target 40, the unit 20 is excreted through metabolism, to thereby prevent a normal cell from being damaged by the drug 14.Type: ApplicationFiled: July 29, 2009Publication date: September 2, 2010Applicant: NANOCARRIER CO., LTD.Inventors: Yasuki Kato, Mitsunori Harada, Hiroyuki Saito, Tatsuyuki Hayashi
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Patent number: 7781607Abstract: There is provided a production method in which bis(nitrato)platinum complex, optionally in the concurrent presence of dihalo-platinum complex, and poly(ethylene glycol)-block-poly(glutamic acid) are used at specific ratios and reacted. Coordination compound of an anti-tumor platinum complex with a block copolymer having carboxyl groups on its side chains is efficiently produced.Type: GrantFiled: June 8, 2006Date of Patent: August 24, 2010Assignees: Nanocarrier Co., Ltd., The University of TokyoInventors: Katsutoshi Kobayashi, Shoko Nagasaki, Kazunori Kataoka, Chieko Tsuchiya
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Patent number: 7470763Abstract: This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.Type: GrantFiled: December 19, 2003Date of Patent: December 30, 2008Assignee: Nanocarrier Co., Ltd.Inventors: Naoya Shibata, Yukio Nagasaki, Kazunori Kataoka
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Production process for polymeric micelle charged therein with drug and polymeric micelle composition
Patent number: 7223419Abstract: Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.Type: GrantFiled: September 22, 2003Date of Patent: May 29, 2007Assignee: Nanocarrier Co., Ltd.Inventors: Masayuki Yokoyama, Eiichi Honzawa, Yasuaki Ogawa -
Publication number: 20060057219Abstract: A production method of a preparation containing drug-encapsulating polymer micelles is provided, which comprises dissolving a hydrophilic-hydrophobic block copolymer and a sparingly water-soluble drug in a volatile organic solvent, then removing the solvent, and stirring the residue with water at a temperature not higher than 30° C. to dissolve the drug-encapsulating polymer micelles into the water.Type: ApplicationFiled: May 21, 2003Publication date: March 16, 2006Applicant: NanoCarrier Co., Ltd.Inventors: Shoko Nagasaki, Chieko Tsuchiya, Katsuhiko Sagawa
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Patent number: 6974856Abstract: Disclosed are block copolymers represented by the following general formula (I) wherein AI represents a hydroxyl group or an organic residue derived from an anionic polymerization initiator, R represents a hydrogen atom or an acyl group, NP represents a residue derived from a nucleophilic reagent, m is an integer of 2 to 20,000, and n is an integer of 1 to 20,000.Type: GrantFiled: June 27, 2000Date of Patent: December 13, 2005Assignee: Nanocarrier Co., Ltd.Inventors: Kazunori Kataoka, Yukio Nagasaki, Yoshitsugu Akiyama
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Patent number: 6881484Abstract: A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed. The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.Type: GrantFiled: May 30, 2001Date of Patent: April 19, 2005Assignees: Mitsubishi Kagaku Iatron, Inc., Nanocarrier Co., Ltd.Inventors: Kazunori Kataoka, Yukio Nagasaki, Naoya Shibata, Nobuhiro Hoshino
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Production process for polymeric micelle charged therein with drug and polymeric micelle composition
Publication number: 20010014354Abstract: Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.Type: ApplicationFiled: February 8, 2001Publication date: August 16, 2001Applicant: NANOCARRIER CO., LTD.Inventors: Masayuki Yokoyama, Eiichi Honzawa, Yasuaki Ogawa