Patents Assigned to Nanocopoeia, LLC
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Patent number: 11633398Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.Type: GrantFiled: August 15, 2022Date of Patent: April 25, 2023Assignee: NANOCOPOEIA, LLCInventors: Christian F. Wertz, Tzehaw Chen
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Patent number: 11559485Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor nilotinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer. In particular, the present disclosure provides a pharmaceutical composition in the form of an orally disintegrating tablet. In some embodiments, the pharmaceutical compositions can be administered without regard to food consumption. In other embodiments, the pharmaceutical compositions can be administered at a significantly lower dose as compared to a commercially available immediate-release nilotinib formulation, while providing a comparable therapeutic effect.Type: GrantFiled: May 24, 2021Date of Patent: January 24, 2023Assignee: NANOCOPOEIA, LLCInventors: Christian F. Wertz, Tzehaw Chen, Joseph McTarsney, Sarah M. Rieschl, Limin Shi
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Patent number: 11413290Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.Type: GrantFiled: December 13, 2021Date of Patent: August 16, 2022Assignee: Nanocopoeia, LLCInventors: Christian F. Wertz, Tzehaw Chen
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Patent number: 11389450Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor nilotinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer. In some embodiments, the pharmaceutical compositions can be administered without regard to food consumption. In other embodiments, the pharmaceutical compositions can be administered at a significantly lower dose as compared to a commercially available immediate-release nilotinib formulation, while providing a comparable therapeutic effect.Type: GrantFiled: April 23, 2021Date of Patent: July 19, 2022Assignee: Nanocopoeia, LLCInventors: Christian F. Wertz, Tzehaw Chen, Joseph McTarsney
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Patent number: 11324745Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.Type: GrantFiled: December 8, 2021Date of Patent: May 10, 2022Assignee: Nanocopoeia, LLCInventors: Christian F. Wertz, Tzehaw Chen
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Patent number: 11298356Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.Type: GrantFiled: December 8, 2021Date of Patent: April 12, 2022Assignee: Nanocopoeia, LLCInventors: Christian F. Wertz, Tzehaw Chen
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Patent number: 11202778Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.Type: GrantFiled: March 19, 2021Date of Patent: December 21, 2021Assignee: Nanocopoeia, LLCInventors: Christian F. Wertz, Tzehaw Chen
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Patent number: 10562048Abstract: Embodiments for producing un-agglomerated, monodisperse droplets using a liquid sheet are provided. Nozzles with exit slit openings shape a spray liquid into a thin liquid sheet as the spray liquid exits from the slit opening. Stable multi-jet operation is achieved by including notches along the edge of the slit. The notches separate the liquid sheet into multiple jets to provide anchoring and stable multi jet operation. In some embodiments, the liquid sheet electrospray techniques and nozzles described herein provide high mass throughput and versatile multiplexing spray systems while reducing the engineering effort and high manufacturing cost.Type: GrantFiled: January 18, 2012Date of Patent: February 18, 2020Assignee: Nanocopoeia, LLCInventors: Daren Chen, Jingjie Zhang