Patents Assigned to Nanoegg Research Laboratories, Inc.
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Publication number: 20190125734Abstract: The present invention provides a composition and a method both for treating or preventing atopic dermatitis effectively. Provided is a composition which contains an acetylcholine inhibitor, e.g., an anticholinergic substance, as an active ingredient. Also provided is a method which includes a step of administering an acetylcholine inhibitor such as an anticholinergic substance. The detailed mechanism of the development of atopic dermatitis has not been elucidated so far. Therefore, it has been difficult to treat atopic dermatitis effectively. The composition according to the present invention can treat atopic dermatitis effectively through the inhibition of the action of acetylcholine.Type: ApplicationFiled: May 9, 2017Publication date: May 2, 2019Applicant: NANOEGG Research Laboratories, Inc.Inventors: Yoko Yamaguchi, Teruaki Nagasawa, Yoshiki Kubota, Nanako Shimura, Mina Musashi
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Patent number: 9809750Abstract: A liquid crystal composition contains liquid crystals containing one kind of or two or more kinds of silicone surfactants, a phenyl-modified silicone oil and water. The liquid crystal composition of the present invention contains 5 to 95% by weight in total of one kind of or two or more kinds of silicone surfactants, 0.1 to 90% by weight of a phenyl-modified silicone oil and 0.1 to 90% by weight of water. The liquid crystal composition of the present invention can solubilize hydrophobic compounds having poor solubility (for example, hydrocarbon oils such as squalane, fatty acids such as oleic acid and lipoic acid and ester oils such as cetyl isooctanoate) and is thus useful, for example, as toiletry materials and cosmetic materials.Type: GrantFiled: September 29, 2010Date of Patent: November 7, 2017Assignee: Nanoegg Research Laboratories, Inc.Inventors: Yoko Yamaguchi, Yuji Yamashita, Takeshi Hamasaki
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Patent number: 9095560Abstract: An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.Type: GrantFiled: September 7, 2010Date of Patent: August 4, 2015Assignees: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko Yamaguchi, Rie Igarashi
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Patent number: 9079874Abstract: Provision of a stable ?-lipoic acid. A method for producing ?-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing ?-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming ?-lipoic acid nanoparticles.Type: GrantFiled: December 12, 2008Date of Patent: July 14, 2015Assignees: Ezaki Glico Co., Ltd., Nanoegg Research Laboratories, Inc.Inventors: Kazuhisa Sugimoto, Hiromi Nishiura, Yoko Yamaguchi, Keiichi Hirata, Yoshiki Kubota
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Patent number: 7968600Abstract: A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.Type: GrantFiled: February 1, 2007Date of Patent: June 28, 2011Assignees: Nanoegg Research Laboratories, Inc., Kemphys Ltd.Inventors: Mitsuko Takenaga, Koichi Shudo, Tetsuro Matsuishi, Miwako Ishido
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Publication number: 20110081418Abstract: An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.Type: ApplicationFiled: September 7, 2010Publication date: April 7, 2011Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko Yamaguchi, Rie Igarashi
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Publication number: 20110065781Abstract: Provision of a stable ?-lipoic acid. A method for producing ?-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing ?-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming ?-lipoic acid nanoparticles.Type: ApplicationFiled: December 12, 2008Publication date: March 17, 2011Applicants: EZAKI GLICO CO., LTD., NANOEGG RESEARCH LABORATORIES, INC.Inventors: Kazuhisa Sugimoto, Hiromi Nishiura, Yoko Yamaguchi, Keiichi Hirata, Yoshiki Kubota
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Publication number: 20100330014Abstract: An object of the present invention is to provide a composition for external application on the skin containing hydroquinone as an active ingredient, which has an excellent skin-whitening activity and reduced side effects. The composition for external application on the skin of the present invention as a means for achieving the object is characterized by containing hydroquinone or a derivative thereof compounded with a lyotropic liquid crystal.Type: ApplicationFiled: January 29, 2009Publication date: December 30, 2010Applicants: TBC GROUP CO., LTD., NANOEGG RESEARCH LABORATORIES, INC., ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINEInventors: Mina Musashi, Keiichi Hirata, Yoko Yamaguchi
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Publication number: 20100305215Abstract: An object of the present invention is to provide a novel dermal regeneration enhancer. In accordance with the present invention, there is provided a dermal regeneration enhancer as a novel pharmaceutical use of lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, and the dermal regeneration enhancer of the present invention achieves an excellent suppressive effect to aging of the skin, generation of spots, etc.Type: ApplicationFiled: June 18, 2010Publication date: December 2, 2010Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko YAMAGUCHI, Rie IGARASHI
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Publication number: 20090075860Abstract: An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.Type: ApplicationFiled: April 28, 2006Publication date: March 19, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko Yamaguchi, Rie Igarashi
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Publication number: 20090017123Abstract: An object of the present invention is to provide a novel dermal regeneration enhancer. In accordance with the present invention, there is provided a dermal regeneration enhancer as a novel pharmaceutical use of lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, and the dermal regeneration enhancer of the present invention achieves an excellent suppressive effect to aging of the skin, generation of spots, etc.Type: ApplicationFiled: April 28, 2006Publication date: January 15, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko Yamaguchi, Rie Igarashi