Abstract: Prior work on differential mobility analysis (DMA) combined with mass spectrometry (MS) has shown how to couple the output of a planar DMA with the atmospheric pressure inlet of an atmospheric pressure ionization mass spectrometer (APCI-MS). However, because the ion inlet to APCI-MS instruments is a round orifice, while conventional DMA geometries make use of elongated slits, the coupling of both has attained less resolving power or tolerated a smaller sample flow rate than a DMA alone. The present invention overcomes these limitations with an axial DMA of cylindrical symmetry using more than two electrodes. The configuration is related to that previously proposed by Labowsky and Fernández de la Mora (2004, 2006), where ions with a critical electrical mobility are brought into the symmetry axis of the DMA. Ions with this critical mobility are now optimally transmitted into the MS, with much higher resolution than possible in planar DMAs.
Type:
Grant
Filed:
April 21, 2008
Date of Patent:
July 31, 2012
Assignees:
Sociedad Europea de Analisis Diferencial de Movilidad, NanoEngineering Corporation
Inventors:
Juan Fernandez De La Mora, Juan Rus, Jerome J. Schmitt, Francisco Estevez-Molinero