Patents Assigned to NANOFIBER SOLUTIONS, INC.
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Publication number: 20190054036Abstract: A fiber may comprise an electrospun polymer and a pharmaceutical. The pharmaceutical may be dispersed within the electrospun polymer, and may have the form of a crystal, an oil, or a combination thereof. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a pharmaceutical. A method of treating a disorder in a subject may comprise obtaining such a fiber having an effective amount of a pharmaceutical, applying the fiber to an oral region of the subject, and allowing the fiber to disintegrate, thereby delivering the effective amount of the pharmaceutical to the subject.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Applicant: NANOFIBER SOLUTIONS, INC.Inventors: Jed JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
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Patent number: 10166315Abstract: A composition may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. Such a composition may further include a plurality of polymeric electrospun fiber fragment clusters. A kit may comprise a first component of a plurality of polymeric electrospun fiber fragments, and a second component of a carrier medium comprising an effective amount of chitosan. A method of treatment may comprise injecting into a portion of a body a composition which may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. The treatment may be directed to one or more of joint inflammation, osteoarthritis, a tissue injury, a muscle tear, a ligament tear, a tendon tear, a void, incontinence, an aneurysm, and a tumor.Type: GrantFiled: May 4, 2016Date of Patent: January 1, 2019Assignee: NANOFIBER SOLUTIONS, INC.Inventors: Jed Johnson, Ronald Lloyd Bracken, Jason Chakroff
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Publication number: 20180272037Abstract: The invention provides devices for supporting regeneration of body tissue and of tubular structures, such as the esophagus or intestine, and methods for making and for using the devices.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Applicants: The Administrators of the Tulane Educational Fund, Nanofiber Solutions, Inc.Inventors: Derek C. DASHTI, Aline M. BETANCOURT, Jed JOHNSON, Ruth WATERMAN
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Patent number: 9884027Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: GrantFiled: January 14, 2013Date of Patent: February 6, 2018Assignee: NANOFIBER SOLUTIONS, INC.Inventor: Jed K. Johnson
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Patent number: 9737632Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.Type: GrantFiled: September 25, 2014Date of Patent: August 22, 2017Assignee: NANOFIBER SOLUTIONS, INC.Inventors: Jed K. Johnson, Ross Kayuha
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Publication number: 20160325019Abstract: The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed.Type: ApplicationFiled: November 13, 2015Publication date: November 10, 2016Applicant: NANOFIBER SOLUTIONS, INC.Inventor: JED JOHNSON
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Publication number: 20160325015Abstract: A composition may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. Such a composition may further include a plurality of polymeric electrospun fiber fragment clusters. A kit may comprise a first component of a plurality of polymeric electrospun fiber fragments, and a second component of a carrier medium comprising an effective amount of chitosan. A method of treatment may comprise injecting into a portion of a body a composition which may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. The treatment may be directed to one or more of joint inflammation, osteoarthritis, a tissue injury, a muscle tear, a ligament tear, a tendon tear, a void, incontinence, an aneurysm, and a tumor.Type: ApplicationFiled: May 4, 2016Publication date: November 10, 2016Applicant: NANOFIBER SOLUTIONS, INC.Inventors: Jed JOHNSON, Ronald Lloyd BRACKEN, Jason CHAKROFF
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Publication number: 20160317706Abstract: A scaffold may comprise a first polymeric electrospun fiber comprising a first material having a first degradation rate, and a second polymeric electrospun fiber comprising a second material having a second degradation rate different from the first degradation rate. The first degradation rate may substantially correspond to a cell infiltration rate, and the second degradation rate may be slower than the first degradation rate. Such a scaffold may be manufactured by electrospinning a first polymer fiber having a first degradation rate by ejecting a first polymer solution from a first polymer injection system onto a mandrel, and electrospinning a second polymer fiber having a second degradation rate different from the first degradation rate by ejecting a second polymer solution from a second polymer injection system onto a mandrel. Wound healing may be improved by applying such a scaffold to a portion of a wound.Type: ApplicationFiled: April 29, 2016Publication date: November 3, 2016Applicant: NANOFIBER SOLUTIONS, INC.Inventor: Jed JOHNSON