Patents Assigned to Nanogen/Becton Dickinson Partnership
  • Electronically mediated nucleic acid amplification in NASBA
    Patent number: 7070961
    Abstract: A method of improving amplification of nucleic acids using a nucleic acid sequence-based amplification (“NASBA”) method is provided wherein target nucleic acids and NASBA primers are electronically addressed to electronically addressable capture sites of a microchip. This improvement uses electronically induced hybridization of the target nucleic acids to the primers. The primers may be solution-based or immobilized on the capture sites of the microchip.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: July 4, 2006
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Carl F. Edman, Michael I. Nerenberg
  • Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification an bioelectronic chip technology
    Patent number: 6864071
    Abstract: This invention relates to devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using ligation-dependent strand displacement amplification technologies in combination with bioelectronic microchip technology.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: March 8, 2005
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: John J. Carrino, Louis O. Gerrue, Jonathan M. Diver
  • Anchored strand displacement amplification on an electronically addressable microchip
    Patent number: 6531302
    Abstract: Methods and compositions of matter are provided for the strand displacement amplification of target nucleic acids of interest using primer pair sets that are anchored to electronically addressable capture sites on a microarray. The primer pair sets may be individually bound to the capture sites or may comprise a unique branched primer pair moiety. The anchored primers allow for the simultaneous multiplex capture, amplification and detection of a target nucleic acid derived from any sample source.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: March 11, 2003
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Michael I. Nerenberg, Carl F. Edman, Lorelei P. Westin, Lana L. Feng, Geoffrey C. Landis, Ronald G. Sosnowski
  • Electronically mediated nucleic acid amplification in NASBA
    Patent number: 6326173
    Abstract: A method of improving amplification of nucleic acids using a nucleic acid sequence-based amplification (“NASBA”) method is provided wherein target nucleic acids and NASBA primers are electronically addressed to electronically addressable capture sites of a microchip. This improvement uses electronically induced hybridization of the target nucleic acids to the primers. The primers may be solution-based or immobilized on the capture sites of the microchip.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: December 4, 2001
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Carl F. Edman, Michael I. Nerenberg
  • Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
    Patent number: 6309833
    Abstract: A method for amplifying nucleic acids is provided wherein detection of amplified species is enhanced by the use of asymmetric amplification. Such amplification is made asymmetric by using divergent ratios of amplification primers or by using non-extending and/or non-cleavable amplification primers. Detection of the amplicons is improved because maintenance of single stranded species of amplicons during amplification facilitates their direct capture by immobilized probes without having to include denaturing steps.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: October 30, 2001
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Carl F. Edman, Michael I. Nerenberg, Lorelei P. Westin, John J. Carrino
  • Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
    Patent number: 6238868
    Abstract: This invention relates to devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using ligation-dependent strand displacement amplification technologies in combination with bioelectronic microchip technology.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: May 29, 2001
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: John J. Carrino, Louis O. Gerrue, Jonathan M. Diver