Abstract: Mikto-arm star polymers were prepared comprising non-charged hydrophilic poly(ethylene oxide) arms and hydrophobic arms comprising a poly(propylene oxide) chain or phytol group. The polymer arms are covalently linked to a hydrophobic crosslinked polyester core formed by ring opening polymerization of a bis-cyclic ester initiated by mono-nucleophilic polymer arm precursors. The mikto-arm star polymers show improved loading capacity for Coenzyme Q10 (CoQ10).
Type:
Grant
Filed:
September 25, 2017
Date of Patent:
November 26, 2019
Assignees:
International Business Machines Corporation, NanoMalaysia Berhad
Inventors:
Khairiah H. Badri, Emilia B. A. Malek, Siti Mariam B. Mohd Nor, Victoria A. Piunova
Abstract: Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.
Type:
Grant
Filed:
July 20, 2017
Date of Patent:
October 29, 2019
Assignees:
International Business Machines Corporation, NanoMalaysia Berhad
Inventors:
Mohd Zulkefeli Bin Mat Jusoh, Alshakim Nelson, Victoria A. Piunova, Joseph Sly