Abstract: A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.

Abstract: A plunger-like mass transporting device and method for controllable transportation of a selected dosage of a solid or liquid composition having a body with a rigid enclosure, and a head, where the head is configured to attach to the body, the head having a stem and a housing. Further, the stem having a first end, the first end having an attachment means to attach to the rigid enclosure containing the body; and a second end, the second end having an attachment means to attach to the housing, and an applicator; wherein a flexible means is disposed on the stem, for providing an up position and a down position during an axial movement of the stem back and forth through the housing, wherein the housing contains the solid or liquid composition.

Abstract: A built-in non-verbal compact instructional device integratable to an applicator having a microdevice for painlessly perforating skin and optionally an active agent for application to the perforated area. The microdevice can include microneedles, microneedle arrays, microblades, microblade arrays, microknives, microknife arrays, and Functional MicroArrays (FMAs). The active agent can be stored in a first chamber. The microdevice can perforate stratum corneum without significant pain or discomfort to a patient. The active agent is applied to the perforated area. The device verifies compliance with predetermined methods of use, such as a light to indicate application with the recommended amount of force for perforating skin. The applicator can provide enhanced delivery of an active agent, with minimal discomfort, for therapeutic or cosmetic treatment, such as topical treatment for acne, or other skin disorders, wrinkles, blemishes, etc.