Abstract: New conjugates having a general formula (I). The conjugates include at least one mannose 6-phosphate analogue targeting the cation-independent mannose 6-phosphate receptor and an antibody or antibody fragment for binding a specific target antigen or target molecule. Also, a process for preparing the conjugates and their medical use, in therapeutic or diagnostic fields. The conjugates of formula (I) are particularly interesting for use as a medicine, particularly in a therapeutic treatment method in which a therapeutic antibody or a therapeutic antibody fragment is administered.

Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Abstract: The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P1, X, n, A, L and L1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P1, X, n, A, L and L?1 are as defined in Claim 6, and the use thereof: —in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or—in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.