Abstract: Provided herein is a first fluid dispersed in a second fluid to form an emulsion of micro-droplets having an average droplet size and having a droplet size distribution around the average droplet size and below a maximum droplet size. The micro-droplets will lose their solvent to transform to micro-spheres exhibiting a particle size distribution around an average particle size and substantially below a maximum allowable particle size. The micro-spheres are subjected to a micro-filter having a relatively narrow pore size distribution around an average pore size, which average pore size is between the average particle size and the maximum particle size. A filtrate of the micro-filter comprises a majority of the micro-spheres that is substantially void of micro-spheres having a particle size exceeding the maximum allowable particle size.

Abstract: Methods for preparing micro-particles using a double emulsion technique combining a membrane and a micro-sieve are provided. Particularly the present invention relates to method for preparing micro-particles comprising: preparing a first phase comprising an active agent; preparing a second phase comprising a carrier and a solvent; passing the first phase and the second phase through a membrane to form a primary emulsion; passing the primary emulsion through a micro-sieve in a continuous phase to form a secondary emulsion; and removing the solvent to form the micro-particles.

Abstract: Methods for preparing micro-particles using a double emulsion technique combining a membrane and a micro-sieve are provided. Particularly the present invention relates to method for preparing micro-particles comprising: preparing a first phase comprising an active agent; preparing a second phase comprising a carrier and a solvent; passing the first phase and the second phase through a membrane to form a primary emulsion; passing the primary emulsion through a micro-sieve in a continuous phase to form a secondary emulsion; and removing the solvent to form the micro-particles.

Abstract: A device for generating microspheres from a fluid includes an injection plate with at least one defined injection channel having on an inlet side an inflow opening for receiving the fluid and on an outlet side an outflow opening for delivering microspheres formed from the fluid. The device includes feed elements for carrying fluid through the injection channel and is in open communication, on a side wall thereof, with at least one secondary channel at least at the position of a break-up point where at least during operation a flow of fluid in the injection channel breaks up into separate parts. The secondary channel includes in use an auxiliary fluid at least at the position of a break-up point.