Patents Assigned to Nanoprobes
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Patent number: 8323694Abstract: Disclosed herein are compositions and methods for increasing the infrared absorptivity of a therapeutic target. Also disclosed are methods for detecting or ablating a therapeutic target that include providing a nanoparticle composition for increasing the infrared absorptivity of the therapeutic target. Subsequently, the therapeutic target having increased infrared absorptivity is exposed to a therapeutically effective dose of infrared irradiation to effect its detection or ablation. In addition, a method is disclosed for treating a subject suffering from a tumor by providing to the tumor a nanoparticle composition for increasing its infrared absorptivity. The tumor having increased infrared absorptivity is then heated by exposing it to a therapeutically effective dose of infrared irradiation.Type: GrantFiled: May 9, 2007Date of Patent: December 4, 2012Assignee: Nanoprobes, Inc.Inventor: James F. Hainfeld
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Publication number: 20120244075Abstract: The present disclosure relates to the product, process, and use of 5 nm Nickel-Nitrilotriacetic acid (Ni-NTA) gold nanoparticles. Applications include diagnostic tests, imaging, therapies, detection technologies, gold conjugation to other molecules, and novel material constructs.Type: ApplicationFiled: March 25, 2011Publication date: September 27, 2012Applicant: Nanoprobes, Inc.Inventors: Wenqiu Liu, James F. Hainfeld
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Patent number: 8033977Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.Type: GrantFiled: March 31, 2009Date of Patent: October 11, 2011Assignee: NanoProbes, Inc.Inventors: James F. Hainfeld, Daniel N. Slatkin
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Patent number: 7951554Abstract: The present invention provides compositions, kits, assemblies of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention concerns using enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using microscopy.Type: GrantFiled: February 17, 2010Date of Patent: May 31, 2011Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Wenqiu Liu
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Patent number: 7906147Abstract: Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commercial applications.Type: GrantFiled: October 12, 2006Date of Patent: March 15, 2011Assignee: Nanoprobes, Inc.Inventor: James F. Hainfeld
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Patent number: 7892781Abstract: A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzyme substrate. A method of detecting a target in a test sample includes exposing the test sample to the probe, then treating the test sample with an enhancement or development solution to deposit at least one of a fluorophore, a chromogen, or a metal.Type: GrantFiled: April 28, 2008Date of Patent: February 22, 2011Assignee: Nanoprobes, Inc.Inventors: Richard D. Powell, Vishwas N. Joshi, James F. Hainfeld
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Patent number: 7888060Abstract: Disclosed embodiments concern site-specific, enzymatic-directed deposition of elemental metal for in-situ analysis. Enzyme substrates are contacted with metal ions and subsequently direct the deposition of elemental metals. Sensitive and selective detection of target molecules, such as biomarkers in various biological samples, can be obtained using various methods, such as in-situ chromogenic immunohistochemical (IHC) detection with bright field light microscopy.Type: GrantFiled: March 4, 2008Date of Patent: February 15, 2011Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Wenqiu Liu, Richard D. Powell, Vishwas N. Joshi
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Patent number: 7691598Abstract: The present invention provides methods for the use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.Type: GrantFiled: March 5, 2007Date of Patent: April 6, 2010Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Wenqiu Liu
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Patent number: 7592153Abstract: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.Type: GrantFiled: January 26, 2007Date of Patent: September 22, 2009Assignee: Nanoprobes, Inc.Inventor: James F. Hainfeld
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Publication number: 20090186060Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.Type: ApplicationFiled: March 31, 2009Publication date: July 23, 2009Applicant: NanoProbes, Inc.Inventors: James F. Hainfeld, Daniel N. Slatkin
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Patent number: 7530940Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.Type: GrantFiled: November 10, 2003Date of Patent: May 12, 2009Assignee: NanoProbes, Inc.Inventors: James F. Hainfeld, Daniel N. Slatkin
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Patent number: 7367934Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.Type: GrantFiled: July 21, 2005Date of Patent: May 6, 2008Assignee: NanoProbes, Inc.Inventors: James F. Hainfeld, Daniel N. Slatkin
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Patent number: 7364872Abstract: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal and deposited. These methods enable a wide range of applications including the detection of one or more constituents in a test sample.Type: GrantFiled: May 4, 2005Date of Patent: April 29, 2008Assignee: NanoprobesInventor: James F. Hainfeld
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Publication number: 20080089836Abstract: Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.Type: ApplicationFiled: October 12, 2006Publication date: April 17, 2008Applicant: Nanoprobes, Inc.Inventor: James F. Hainfeld
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Patent number: 7183072Abstract: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.Type: GrantFiled: September 8, 2003Date of Patent: February 27, 2007Assignee: Nanoprobes, Inc.Inventor: James F. Hainfeld
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Patent number: 6955639Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.Type: GrantFiled: March 12, 2003Date of Patent: October 18, 2005Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Daniel N. Slatkin
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Patent number: 6670113Abstract: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally, disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.Type: GrantFiled: March 30, 2001Date of Patent: December 30, 2003Assignee: NanoprobesInventor: James F. Hainfeld
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Patent number: 6121425Abstract: Novel metal-lipid molecules have the formula M-Or-L. M represents a cluster or colloid of atoms of Au, Ag, Pt, Pd, or combinations thereof. Or is an organic group covalently attached to the metal atoms. L represents a lipid moiety. In a preferred embodiment, M represents a cluster of about 50-70 gold atoms having a diameter of about 1.4 nm in diameter and L represents dipalmitoyl phosphatidyl ethanolamine.Type: GrantFiled: March 16, 1998Date of Patent: September 19, 2000Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Frederic R. Furuya, Richard D. Powell, Vishwas N. Joshi, Edmund Gutierrez
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Patent number: 5728590Abstract: Small organometallic probes are disclosed which include a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe is disclosed which includes a core of metal atoms surrounded by a shell of organic moieties covalently attached to the metal atoms, a fluorescent molecule, e.g., fluorescein, covalently attached to one of the organic moieties, and a targeting molecule, e.g., an antibody, covalently attached to another of the organic moieties. In another embodiment, a small metal cluster of palladium or platinum is disclosed in which the central metal core comprises platinum or palladium in which the central metal core is from about 1.8 to 3.6 nm in diameter and contains about 309 to about 2,057 metal atoms. This metal core has 1,10-phenanthroline organic moieties covalently attached to the metal core. A process for making this palladium and platinum cluster compound is also disclosed.Type: GrantFiled: May 23, 1996Date of Patent: March 17, 1998Assignee: Nanoprobes, Inc.Inventor: Richard D. Powell
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Patent number: 5521289Abstract: Small organometallic probes comprise a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe comprises a core of metal atoms surrounded by a shell of organic moieties covalently attached to the metal atoms, a fluorescent molecule, e.g., fluorescein, covalently attached to one of the organic moieties, and a targeting molecule, e.g., an antibody, covalently attached to another of the organic moieties.Type: GrantFiled: July 29, 1994Date of Patent: May 28, 1996Assignee: Nanoprobes, Inc.Inventors: James F. Hainfeld, Robert D. Leone, Frederic R. Furuya, Richard D. Powell