Abstract: Four major polymeric architectures, namely: (a) linear, (b) branched, (c) hyperbranched/dendritic and (d) cross-linked polymers, when formed by reaction of multifunctional alcohols, such as sugar-based alpha-, beta- or gamma-cyclodextrins, with multi-carboxylic acids form unique polyester copolymers. These copolymers have been demonstrated to substantially enhance the water-solubility and bioavailability of water insoluble compounds for a wide variety of uses.
Type:
Application
Filed:
December 15, 2022
Publication date:
April 20, 2023
Applicant:
NanoSynthons LLC
Inventors:
Donald A. Tomalia, David M. Hedstrand, Mayank K. Singh, Linda S. Nixon
Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.
Type:
Grant
Filed:
July 12, 2019
Date of Patent:
April 6, 2021
Assignee:
NanoSynthons LLC
Inventors:
Donald A Tomalia, David M Hedstrand, Linda S Nixon
Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.
Type:
Application
Filed:
July 12, 2019
Publication date:
November 21, 2019
Applicant:
NanoSynthons LLC
Inventors:
Donald A. Tomalia, David M. Hedstrand, Linda S. Nixon
Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.
Type:
Grant
Filed:
September 14, 2015
Date of Patent:
September 24, 2019
Assignee:
NanoSynthons LLC
Inventors:
Donald A Tomalia, David M Hedstrand, Linda S Nixon
Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.
Type:
Application
Filed:
September 14, 2015
Publication date:
August 31, 2017
Applicant:
NanoSynthons LLC
Inventors:
Donald A Tomalia, David M Hedstrand, Linda S Nixon