Abstract: This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 0 to 12m is 1 or 2 ##STR2## R.sup.1 is X and Z are independently H or NR.sup.2 COR.sup.3Y is CO.sub.2, CH.sub.2 O, O or NH andR.sup.2 and R.sup.3 are independently H, alkyl having from 1 to 12 carbon atoms or aryl having from 6 to 11 carbon atoms,This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is ##STR3## R.sup.2 is H and R.sup.3 is CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.

Abstract: Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclaving and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

Abstract: A process of preparing nanoparticulate drug substances comprising the steps of: preparing a premix of the drug substance and a surface modifier, and subjecting the premix to mechanical means to reduce the particle size of the drug substance, the mechanical means producing shear, impact, cavitation and attrition.