Patents Assigned to Nanotherapeutics, Inc.
  • Patent number: 9771564
    Abstract: The present invention provides a novel influenza virus wherein both the NS and the PB1 gene segments are modified and wherein the PB1-F2 open reading frame is modified by introduction of at least one stop codon. Specifically, the influenza virus is lacking functional NS1 and PB1-F2 proteins. Additionally, a vaccine formulation comprising the modified influenza virus is provided and its use for prevention of influenza vaccination.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: September 26, 2017
    Assignee: NANOTHERAPEUTICS, INC.
    Inventors: Thomas Muster, Ekaterina Romanovskaya-Romanko, Oleg Kiselev, Markus Wolschek, Boris Ferko, Andrej Egorov
  • Patent number: 9554996
    Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: January 31, 2017
    Assignee: NANOTHERAPEUTICS, INC.
    Inventor: James David Talton
  • Publication number: 20160376552
    Abstract: The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
    Type: Application
    Filed: July 11, 2016
    Publication date: December 29, 2016
    Applicant: Nanotherapeutics, Inc.
    Inventors: Manfred Reiter, Wolfgang Mundt, Simone Feigl, Simone Von Fircks
  • Patent number: 9388380
    Abstract: The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: July 12, 2016
    Assignee: NANOTHERAPEUTICS, INC.
    Inventors: Manfred Reiter, Wolfgang Mundt, Simone Feigl, Simone Von Fircks
  • Patent number: 9040091
    Abstract: The present disclosure is directed to compositions comprising encapsulated particles of diethylenetriaminepentaacetate (DTPA) and a zinc salt such as zinc acetate, and to pharmaceutical compositions comprising such encapsulated compositions. The present disclosure is also directed to methods of treatment by administering an effective amount of the compositions and pharmaceutical compositions of the present disclosure, to methods of making such encapsulated particle compositions, and to methods of making the corresponding pharmaceutical compositions.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 26, 2015
    Assignee: NANOTHERAPEUTICS, INC.
    Inventor: James David Talton
  • Patent number: 8501232
    Abstract: The present invention relates to processes for forming particles including drugs in a solution, changing the bulk or surface properties of a drug particle, and/or microencapsulating drug particles, and compositions produced thereby. In some embodiments, the process described utilizes mechanical agitation, more specifically low-frequency sonication, under controlled conditions, which provides mild shear forces during forming and/or precipitation to control the particle growth and mixing properties. Particle size can range from less than about 200 nanometers to greater than about one millimeter, depending on the processing conditions and application.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: August 6, 2013
    Assignee: Nanotherapeutics, Inc.
    Inventors: James D. Talton, Christopher McConville
  • Publication number: 20130129828
    Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.
    Type: Application
    Filed: January 15, 2013
    Publication date: May 23, 2013
    Applicant: Nanotherapeutics, Inc.
    Inventor: James David Talton
  • Patent number: 8377479
    Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: February 19, 2013
    Assignee: Nanotherapeutics, Inc.
    Inventor: James D. Talton
  • Patent number: 8114894
    Abstract: Disclosed herein are compounds that may be modulators of 5-HT receptors, and methods of making and using same.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: February 14, 2012
    Assignee: Nanotherapeutics, Inc.
    Inventors: Shomir Ghosh, Gali Golan, Boaz Inbal, Vincent Jacques, Mercedes Lobera
  • Patent number: 8074906
    Abstract: A method of milling a powder comprising introducing a gas stream containing a cryogenic liquid and a drug carrier gas into a jet mill, and milling a powder with the jet mill in one or more milling passes. A product produced by the method. A milling apparatus comprising a cryogenic gas input system, a powder feeder, a main jet-mill, and at least one output port for collecting the powder.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: December 13, 2011
    Assignee: Nanotherapeutics, Inc.
    Inventor: James D. Talton
  • Patent number: 8026395
    Abstract: The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: September 27, 2011
    Assignee: Nanotherapeutics, Inc.
    Inventors: Xu Lin, Ivan King
  • Patent number: 7982040
    Abstract: The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: July 19, 2011
    Assignee: Nanotherapeutics, Inc.
    Inventors: Dale S. Dhanoa, Oren Becker, Silvia Noiman, Pradyumna Mohanty, Dongli Chen, Mercedes Lobera, Laurence Wu, Yael Marantz, Boaz Inbal, Alexander Heifetz, Shay Bar-Haim, Sharon Shacham
  • Patent number: 7846459
    Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: December 7, 2010
    Assignee: Nanotherapeutics, Inc.
    Inventors: James D. Talton, James F. Kirk
  • Patent number: 7829105
    Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: November 9, 2010
    Assignee: Nanotherapeutics, Inc.
    Inventors: James D. Talton, James F. Kirk
  • Publication number: 20100129448
    Abstract: Compositions for topical application to the skin and/or a wound are disclosed. In some embodiments, the compositions include a suspension or dispersion of particles of at least one poorly soluble drug chelated or otherwise complexed with a metal salt. The compositions may further contain at least one stabilizer, at least one excipient, and at least one physiologically acceptable carrier. Methods for making such compositions, pharmaceutical formulations containing such compositions, and methods of treatment utilizing such compositions are also disclosed.
    Type: Application
    Filed: August 18, 2009
    Publication date: May 27, 2010
    Applicant: Nanotherapeutics, Inc.
    Inventor: James D. Talton
  • Patent number: 7705135
    Abstract: Pectins having a combination of unexpectedly high molecular weights and low degrees of methylation have been isolated from Aloe vera plants, are superior gel pectins for forming calcium cross-lined gels. Such pectins can be obtained by extracting homogenized Aloe Vera plants or portions thereof. These pectins can be used to prepare pharmaceutical compositions comprising pharmacological agents for application to animals and humans, so as to provide controlled release of the pharmacological agent.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: April 27, 2010
    Assignee: Nanotherapeutics, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates, Ryszard Zarzycki
  • Patent number: 7691986
    Abstract: Pectins having a combination of unexpectedly high molecular weights and low degrees of methylation have been isolated. These high molecular weight, low degree of methylation pectins form gels at unexpectedly low concentrations. Such pectins can be obtained by extracting homogenized Aloe Vera plants or portions thereof. These pectins can be used to prepare pharmaceutical compositions comprising pharmacological agents encapsulated in a pectin gel, for application to animals and humans so as to provide controlled release of the pharmacological agent.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: April 6, 2010
    Assignee: Nanotherapeutics, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates, Ryszard Zarzycki
  • Publication number: 20090061011
    Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.
    Type: Application
    Filed: September 2, 2008
    Publication date: March 5, 2009
    Applicant: Nanotherapeutics, Inc.
    Inventor: James D. TALTON
  • Publication number: 20080014279
    Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 17, 2008
    Applicant: Nanotherapeutics, Inc.
    Inventors: James Talton, James Kirk
  • Publication number: 20080008766
    Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 10, 2008
    Applicant: Nanotherapeutics, Inc.
    Inventors: James Talton, James Kirk