Patents Assigned to NANOTHETA CO, LTD.
-
Patent number: 10940229Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.Type: GrantFiled: September 29, 2017Date of Patent: March 9, 2021Assignees: Toray Industries, Inc., Nanotheta Co., Ltd.Inventors: Akihiro Saito, Megumi Nakanishi, Kazuhiro Tanahashi, Toru Arakane, Motonori Hochi, Ai Suzuki, Koji Okabayashi, Shinji Takeoka, Toshinori Fujie, Yuya Ishiduka, Shinya Ohtsubo
-
Patent number: 10858490Abstract: A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.Type: GrantFiled: February 22, 2018Date of Patent: December 8, 2020Assignees: Nanotheta Co, Ltd., Shinji Takeoka, Toray Industries, Inc.Inventors: Shinji Takeoka, Akihiro Saito, Hong Zhang, Natsuki Takamizawa
-
Patent number: 10563025Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.Type: GrantFiled: May 11, 2016Date of Patent: February 18, 2020Assignees: Toray Industries, Inc., Nanotheta Co, Ltd.Inventors: Motonori Hochi, Yuki Sekido, Ichiro Itagaki, Toru Arakane, Shinya Ohtsubo, Shinji Takeoka, Atsushi Murata, Mao Fujii, Yuya Ishizuka, Shuichi Shoji, Jun Mizuno, Takashi Kasahara
-
Patent number: 10531988Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.Type: GrantFiled: December 4, 2015Date of Patent: January 14, 2020Assignees: Toray Industries, Inc., NANOTHETA CO, LTD.Inventors: Motonori Hochi, Yuki Sekido, Akihiro Saito, Shinji Takeoka, Shinya Ohtsubo, Akinari Hinoki, Manabu Kinoshita
-
Patent number: 10213530Abstract: A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.Type: GrantFiled: June 17, 2016Date of Patent: February 26, 2019Assignees: Toray Industries, Inc., Nanotheta Co, Ltd.Inventors: Akihiro Saito, Toru Arakane, Kazuhiro Tanahashi, Koji Okabayashi, Shinji Takeoka, Toshinori Fujie, Shoichiro Suzuki, Atsushi Murata, Shinya Otsubo
-
Patent number: 10119000Abstract: Our invention is a laminate film comprising a water-soluble resin layer and a polylactic acid-based resin layer laminated on at least one side of a substrate film, the water-soluble resin layer has a thickness of 0.1 to 15 ?m, the polylactic acid-based resin layer has a thickness of 10 to 500 nm. Such a configuration provides a laminate film of which the water-soluble resin layer and the polylactic acid-based resin layer are easily separated from the substrate film and which is excellent in coating ability, adherence and followability to a soft and curved adherend, as well as compatibility to skin and organs such as viscera, so as to be suitable for wound dressing, adhesion prevention material and a skin external agent such as skin-care product.Type: GrantFiled: March 6, 2014Date of Patent: November 6, 2018Assignees: TORAY INDUSTRIES, INC., NANOTHETA CO, LTD.Inventors: Motonori Hochi, Yuki Goto, Katsuhiro Minomo, Naomi Tamimiya
-
Patent number: 10035337Abstract: A method for preparing a thin film polymer structure having a functional substance on an A surface and a B surface of the film, the polymer structure being obtained by: (a) adsorbing polyfunctional molecules to a region of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then forming a soluble support film on the A surface; (d) exfoliating the thin film and the soluble support film from the substrate body; and (e) bonding to the B surface of the thin film a functional substance identical to or different from the functional substance bonded to the A surface and then dissolving the soluble support film with a solvent.Type: GrantFiled: October 29, 2007Date of Patent: July 31, 2018Assignees: NANOTHETA CO, LTD., TORAY INDUSTRIES, INC.Inventors: Shinji Takeoka, Yosuke Okamura, Toshinori Fujie, Saori Utsunomiya, Takahiro Goto
-
Patent number: 9956751Abstract: A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then (d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body; (e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent.Type: GrantFiled: May 29, 2013Date of Patent: May 1, 2018Assignees: NANOTHETA CO, LTD., TORAY INDUSTRIES, INC.Inventors: Shinji Takeoka, Yosuke Okamura, Toshinori Fujie, Saori Utsunomiya, Takahiro Goto
-
Patent number: 9938384Abstract: The objective of the present invention is to provide a porous ultra-thin polymer film, and a method for producing said porous ultra-thin polymer film. The present invention provides a porous ultra-thin polymer film with a film thickness of 10 nm-1000 nm. In addition, the present invention provides a method for producing a porous ultra-thin polymer film, comprising the steps of: dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.Type: GrantFiled: March 12, 2013Date of Patent: April 10, 2018Assignees: Nanotheta Co, Ltd., Toray Industries, Inc.Inventors: Shinji Takeoka, Akihiro Saito, Hong Zhang, Natsuki Takamizawa
-
Publication number: 20170354615Abstract: The present invention provides a pharmaceutical preparation comprising a layer-by-layer thin film that is produced by alternately layering a polycation and a polyanion, and a drug loaded onto the layer-by-layer thin film. As a result, a pharmaceutical preparation with a prolonged duration of drug action with a single dose is provided.Type: ApplicationFiled: July 27, 2017Publication date: December 14, 2017Applicants: NANOTHETA CO, LTD., TORAY INDUSTRIES, INC.Inventors: Shinji TAKEOKA, Kenji KASHIWAGI, Toshinori FUJIE, Akihiro SAITO, Hiroki HANIUDA
-
Publication number: 20170348465Abstract: A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.Type: ApplicationFiled: June 17, 2016Publication date: December 7, 2017Applicants: Toray Industries, Inc., Nanotheta Co., Ltd.Inventors: Akihiro Saito, Toru Arakane, Kazuhiro Tanahashi, Koji Okabayashi, Shinji Takeoka, Toshinori Fujie, Shoichiro Suzuki, Atsushi Murata, Shinya Otsubo
-
Publication number: 20160002422Abstract: Our invention is a laminate film comprising a water-soluble resin layer and a polylactic acid-based resin layer laminated on at least one side of a substrate film, the water-soluble resin layer has a thickness of 0.1 to 15 ?m, the polylactic acid-based resin layer has a thickness of 10 to 500 nm. Such a configuration provides a laminate film of which the water-soluble resin layer and the polylactic acid-based resin layer are easily separated from the substrate film and which is excellent in coating ability, adherence and followability to a soft and curved adherend, as well as compatibility to skin and organs such as viscera, so as to be suitable for wound dressing, adhesion prevention material and a skin external agent such as skin-care product.Type: ApplicationFiled: March 6, 2014Publication date: January 7, 2016Applicants: NANOTHETA CO, LTD., TORAY INDUSTRIES, INC.Inventors: Motonori HOCHI, Yuki GOTO, Katsuhiro MINOMO, Naomi TAMIMIYA
-
Patent number: 8871252Abstract: The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment. The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.Type: GrantFiled: March 10, 2010Date of Patent: October 28, 2014Assignee: Nanotheta Co, Ltd.Inventors: Shinji Takeoka, Yousuke Obata, Satoru Nakagawa, Shinya Ohtsubo, Yuji Kawasaki
-
Publication number: 20140120144Abstract: The present invention provides a thin film having an excellent manageability, moisture-retaining effect, and unevenness correction effect and a thin film cosmetic. The thin film of the present invention is a laminate of (a) a base film supporting hyaluronic acid or a derivative thereof and (b) a carrier, wherein the thickness of film (a) is 10 to 500 nm.Type: ApplicationFiled: June 14, 2012Publication date: May 1, 2014Applicants: NANOTHETA CO., LTD., SHISEIDO COMPANY, LTD.Inventors: Koji Abe, Satoshi Yamaki, Eriko Takeoka, Tomoko Kimura, Naomi Kunisawa, Shinji Takeoka, Toshinori Fujie, Kohki Kabata, Akihiro Saito
-
Publication number: 20140086973Abstract: The present invention provides a pharmaceutical preparation comprising a layer-by-layer thin film that is produced by alternately layering a polycation and a polyanion, and a drug loaded onto the layer-by-layer thin film. As a result, a pharmaceutical preparation with a prolonged duration of drug action with a single dose is provided.Type: ApplicationFiled: March 23, 2012Publication date: March 27, 2014Applicant: NANOTHETA CO, LTD.Inventors: Shinji Takeoka, Kenji Kashiwagi, Toshinori Fujie, Akihiro Saito, Hiroki Haniuda