Abstract: A material includes a metallic, nanoporous structure having a plurality of nanopores having a porosity that allows passage of insulin but not IgG. The metallic nanoporous structure includes titanium, 316L stainless steel and may have a textured nano-sericeous surface. A nanoporous bicontinuous structure can be integrated with nanopores.
Type:
Grant
Filed:
December 13, 2023
Date of Patent:
March 11, 2025
Assignee:
NanoVault Medical LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster, Janet E. Davis
Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Type:
Grant
Filed:
August 5, 2020
Date of Patent:
January 2, 2024
Assignee:
NanoVault Medical, LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster, Janet E. Davis
Abstract: A material includes a metallic, nanoporous structure having a plurality of nanopores having a porosity that allows passage of insulin but not IgG. The metallic nanoporous structure includes titanium, 316L stainless steel and may have a textured nano-sericeous surface. A nanoporous bicontinuous structure can be integrated with nanopores.
Type:
Grant
Filed:
October 24, 2022
Date of Patent:
January 2, 2024
Assignee:
NanoVault Medical, LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster, Janet E. Davis
Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Type:
Grant
Filed:
January 26, 2022
Date of Patent:
January 2, 2024
Assignee:
NanoVault Medical, LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster, Janet E. Davis
Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Type:
Grant
Filed:
September 12, 2018
Date of Patent:
August 25, 2020
Assignee:
NanoVault Medical LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster
Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Type:
Grant
Filed:
June 6, 2015
Date of Patent:
October 9, 2018
Assignee:
NanoVault Medical LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster
Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Type:
Application
Filed:
June 6, 2015
Publication date:
November 9, 2017
Applicant:
Nanovault Medical, LLC
Inventors:
Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster