Patents Assigned to Nanovis LLC
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Publication number: 20240050629Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: ApplicationFiled: October 5, 2023Publication date: February 15, 2024Applicant: Nanovis, LLCInventors: Matthew HEDRICK, Chang YAO
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Publication number: 20230414491Abstract: The present disclosure relates to a kit for preventing, reducing, and/or treating surgical site infections, the kit comprising two or more antimicrobial components directed to two or more different post-surgical tissue depths in a subject. The present disclosure further relates to an antimicrobial surgical system, the system comprising two or more antimicrobial components directed to two or more different post-surgical tissue depths in a subject for preventing, reducing, and/or treating surgical site infections. The present disclosure further relates to a method of preventing, reducing, and/or treating one or more surgical site infections, the method comprising: providing an antimicrobial surgical system comprising: two or more antimicrobial components directed to two or more different post-surgical tissue depths in a subject; and applying said antimicrobial surgical system to a subject under conditions effective to prevent, reduce, and/or treat one or more surgical site infections.Type: ApplicationFiled: June 13, 2023Publication date: December 28, 2023Applicant: Nanovis, LLCInventors: David Alan DETWILER, Matthew HEDRICK
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Patent number: 11844835Abstract: Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.Type: GrantFiled: August 30, 2021Date of Patent: December 19, 2023Assignees: PURDUE RESEARCH FOUNDATION, NANOVIS, LLCInventors: Allen Lawrence Garner, Ram Anand Vadlamani, David Alan Detwiler
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Patent number: 11779684Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: GrantFiled: August 27, 2021Date of Patent: October 10, 2023Assignee: NANOVIS, LLCInventors: Matthew Hedrick, Chang Yao
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Patent number: 11129924Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: GrantFiled: January 30, 2020Date of Patent: September 28, 2021Assignee: NANOVIS, LLCInventors: Matthew Hedrick, Chang Yao
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Patent number: 11123428Abstract: Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.Type: GrantFiled: August 12, 2020Date of Patent: September 21, 2021Assignees: Purdue Research Foundation, Nanovis, LLCInventors: Allen Lawrence Garner, Ram Anand Vadlamani, David Alan Detwiler
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Patent number: 10576186Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: GrantFiled: September 26, 2016Date of Patent: March 3, 2020Assignee: NANOVIS, LLCInventors: Matthew Hedrick, Chang Yao
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Publication number: 20170296702Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: ApplicationFiled: September 26, 2016Publication date: October 19, 2017Applicant: NANOVIS, LLCInventors: MATTHEW HEDRICK, CHANG YAO
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Publication number: 20170007743Abstract: An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.Type: ApplicationFiled: September 26, 2016Publication date: January 12, 2017Applicant: NANOVIS, LLCInventors: MATTHEW HEDRICK, CHANG YAO
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Publication number: 20110301716Abstract: A method to enhance osteoblast functionality of a medical implant. The method may include obtaining the medical implant and treating a surface of the medical implant to modify the surface characteristics causing increase functionality of adjacent positioned osteoblasts. A method of increasing cellular activity of a medical implant is also disclosed. A medical device having enhanced cytocompatibility capabilities includes a metallic substrate with an outer surface. Attached to the outer surface is a composition of nanosized structures. A biosensor for use with a medical device, includes an electrode that is attached to an outer surface of the medical device. The biosensor measures electrochemical changes adjacent to the medical implant. Further, a method of manufacturing a medical implant with a biosensor for use in vivo and a method of integrating a biosensor with a medical implant for use in monitoring conductivity and electrochemical changes adjacent to the medical implant are disclosed.Type: ApplicationFiled: July 10, 2008Publication date: December 8, 2011Applicant: NANOVIS, LLC.Inventors: Sirinrath Sirivisoot, Chang Yao, Xingcheng Xiao, Brian Sheldon, Thomas Webster
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Publication number: 20020196826Abstract: A laser device, in particular a semiconductor laser, emitting optical radiation with a defined mode pattern can be produced from a standard Fabry-Perot (FP) laser by post-processing at the wafer level, i.e. before the wafer is separated into individual dies by cleaving/dicing. A sub-cavity is formed within the FP laser cavity. The sub-cavity has a predetermined length and is located between the FP facets. An aperiodic grating composed of a small number of contrast elements, typically less than 10, with predetermined inter-element separations and predetermined spacings relative to the sub-cavity is formed on or in the optical waveguide. The inter-element separations and the spacings relative to the sub-cavity produce a filtering function of the aperiodic grating for optical radiation propagating in the waveguide. The laser device is suitable for telecommunications applications due to its high side-mode-suppression ratio and narrow-linewidth.Type: ApplicationFiled: June 3, 2002Publication date: December 26, 2002Applicant: Nanovis LLCInventors: Robert J. Mears, Augustin Yiptong, Adam D. Cohen
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Patent number: D681204Type: GrantFiled: April 23, 2012Date of Patent: April 30, 2013Assignee: Nanovis, LLCInventors: Jeffrey Farris, Heidi Rorick, Matthew Hedrick, John Williams, Greg Hoffman, Alan McGee, Daniel Refai, John Gorup
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Patent number: D681205Type: GrantFiled: April 23, 2012Date of Patent: April 30, 2013Assignee: Nanovis, LLCInventors: Jeffrey Farris, Heidi Rorick, Matthew Hedrick, John Williams, Greg Hoffman, Alan McGee, Daniel Refai, John Gorup
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Patent number: D681812Type: GrantFiled: April 23, 2012Date of Patent: May 7, 2013Assignee: Nanovis, LLCInventors: Jeffrey Farris, John Williams, Greg Hoffman, Alan McGee, Daniel Refai, John Gorup
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Patent number: D682427Type: GrantFiled: April 23, 2012Date of Patent: May 14, 2013Assignee: Nanovis, LLCInventors: Jeffrey Farris, Heidi Rorick, Matthew Hedrick, John Williams, Greg Hoffman, Alan McGee, Daniel Refai, John Gorup
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Patent number: D718860Type: GrantFiled: April 23, 2012Date of Patent: December 2, 2014Assignee: Nanovis, LLCInventors: Jeffrey Farris, Heidi Rorick, Matthew Hedrick, John Williams, Greg Hoffman, Alan McGee, Daniel Refai, John Gorup