Patents Assigned to NantBio Inc.
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Publication number: 20240124598Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against CD30. Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals diagnosed with hematopoietic malignancies, including Hodgkin lymphoma, CD30-positive B cell lymphomas, CD30-positive T cell lymphomas, CD30-positive NK cell lymphomas.Type: ApplicationFiled: September 8, 2023Publication date: April 18, 2024Applicant: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Helty Adisetiyo, Hermes J. Garban, Mark Guido, Heather McFarlane, Tan Trinh, Shiho Tanaka
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Patent number: 11939585Abstract: Systems and methods are provided for transfecting immune competent cells with RNA at high efficiency and viability.Type: GrantFiled: June 17, 2020Date of Patent: March 26, 2024Assignee: NantBio, Inc.Inventors: Marcos Sixto, Kayvan Niazi, Ting Wu, Chihwei Chang
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Patent number: 11912756Abstract: Compositions, methods and uses of high-diversity nucleic acid library that encodes a plurality of antibodies or antibody fragments are presented. The high-diversity nucleic acid library comprises or is derived from (1) a VH-CDR1/2 sub-library, (2) a plurality of VH-CDR3 sub-libraries, and (3) a VL sub-library, each of which comprises a plurality of members. Preferably, each member of the sub-libraries comprises at least one random cassette that has a plurality of degenerate base positions. In an especially preferred embodiment, at least portions of at least two members of the VH-CDR1/2 sub-library, the plurality of VH-CDR3 sub-libraries, and the VL sub-library are recombined to form an expression library member in an expression library, where each member of the expression library encodes a distinct antibody or antibody fragment.Type: GrantFiled: April 21, 2021Date of Patent: February 27, 2024Assignee: NantBio, Inc.Inventor: Clifford Anders Olson
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Publication number: 20230406918Abstract: Compositions, methods, and uses of recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.Type: ApplicationFiled: May 30, 2023Publication date: December 21, 2023Applicant: NantBio, Inc.Inventors: Patrick Soon-Shiong, Kayvan Niazi, Shiho Tanaka, Jon Thomas Van Lew, Clifford Anders Olson, Philip T. Liu
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Patent number: 11814436Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against CD30. Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals diagnosed with hematopoietic malignancies, including Hodgkin lymphoma, CD30-positive B cell lymphomas, CD30-positive T cell lymphomas, CD30-positive NK cell lymphomas.Type: GrantFiled: February 24, 2022Date of Patent: November 14, 2023Assignee: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Helty Adisetiyo, Hermes J. Garban, Mark Guido, Heather McFarlane, Tan Trinh, Shiho Tanaka
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Patent number: 11773187Abstract: Compositions and methods are presented that allow for an enhanced immune response against a GPI-anchored tumor associated antigen by modification of the protein portion of the TAA to include a transmembrane domain and a trafficking signal that directs the modified protein to the endosomal or lysosomal compartment. Most preferably, the modified protein will no longer have a GPI anchor or GPI attachment sequence.Type: GrantFiled: January 15, 2019Date of Patent: October 3, 2023Assignee: NantBio, Inc.Inventors: Kayvan Niazi, Wael Tadros, Annie Shin
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Patent number: 11773158Abstract: Compositions, methods, and uses of recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.Type: GrantFiled: July 14, 2020Date of Patent: October 3, 2023Assignee: NantBio, Inc.Inventors: Patrick Soon-Shiong, Kayvan Niazi, Shiho Tanaka, Jon Thomas Van Lew, Clifford Anders Olson, Philip T. Liu
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Publication number: 20230287113Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.Type: ApplicationFiled: April 18, 2023Publication date: September 14, 2023Applicant: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Hermes J. Garban, Raymond Wong, Shiho Tanaka
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Patent number: 11756651Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.Type: GrantFiled: December 21, 2018Date of Patent: September 12, 2023Assignees: Nantomics LLC, NantBio, Inc., Nant Holdings IP, LLCInventors: Kevin B. Givechian, Kamil A. Wnuk, Chad Garner, Stephen Charles Benz, Hermes J. Garban, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
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Patent number: 11753467Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.Type: GrantFiled: January 28, 2022Date of Patent: September 12, 2023Assignee: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Hermes J. Garban, Raymond Wong, Shiho Tanaka
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Publication number: 20230270879Abstract: Compositions, methods, and uses of recombinant B7-H4 protein or binding motifs to B7-H4 protein that can reduce the immune suppression effect of B7-H4 in relation to T cell activation, proliferation, and conversion. Preferably, the recombinant B7-H4 protein has a plurality of mutations in N-glycosylation residue to reduce its inhibitory effect to T cell activation and proliferation. The recombinant protein having binding motifs to B7-H4 protein preferably includes a binding motif to IgC domain and another binding motif to IgV domain such that the immune-suppressive effects by two Ig-like domains are concurrently reduced.Type: ApplicationFiled: February 28, 2023Publication date: August 31, 2023Applicant: NantBio, Inc.Inventors: Benjamin Schilling, C. Anders Olson, Philip T. Liu, Shiho Tanaka
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Publication number: 20230230654Abstract: The invention provides a method of validating a predicted pathway activity of a pathway in a solid tumor of a subject, with a digital computer, the method including: a) obtaining a tumor associated sample from the subject; b) obtaining omics data from the tumor associated sample obtained in (a); c) applying the omics data obtained in (b) to a digital computer programmed with a pathway analysis engine configured to generate predicted tumor cell pathway activities in silico, to provide a prediction of one or more pharmaceutically active anticancer compounds effective for treating the subject’s tumor; and d) obtaining enriched viable tumor cells from the subject, and interrogating the enriched viable tumor cells with at least one pharmaceutically active compound known to interact with a pathway element of one or more of the pathways predicted by (c), to measure anticancer activity of the at least one pharmaceutically active compound with respect to the subject’s enriched viable tumor cells.Type: ApplicationFiled: March 16, 2023Publication date: July 20, 2023Applicants: NantBio, Inc., Nant Holdings IP, LLCInventors: Kayvan NIAZI, Shahrooz RABIZADEH, Nicholas J. WITCHEY
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Patent number: 11672873Abstract: Compositions, methods, and uses of recombinant B7-H4 protein or binding motifs to B7-H4 protein that can reduce the immune suppression effect of B7-H4 in relation to T cell activation, proliferation, and conversion. Preferably, the recombinant B7-H4 protein has a plurality of mutations in N-glycosylation residue to reduce its inhibitory effect to T cell activation and proliferation. The recombinant protein having binding motifs to B7-H4 protein preferably includes a binding motif to IgC domain and another binding motif to IgV domain such that the immune-suppressive effects by two Ig-like domains are concurrently reduced.Type: GrantFiled: September 21, 2020Date of Patent: June 13, 2023Assignee: NantBio, Inc.Inventors: Benjamin Schilling, C. Anders Olson, Philip T. Liu, Shiho Tanaka
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Patent number: 11573230Abstract: Methods for rapidly confirming production of infectious viral vectors, for use in clinical grade personalized neo-antigen vaccines for subjects in need thereof, are provided.Type: GrantFiled: January 25, 2019Date of Patent: February 7, 2023Assignees: NantCell, Inc., NantBio, Inc.Inventors: Adrian E. Rice, Kayvan Niazi, Frank R. Jones
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Publication number: 20220403413Abstract: Systems and methods are presented that allow for determination and prediction of payload toxicity in therapeutic viruses. Disclosed herein are methods of determining payload toxicity of an expressed polypeptide in a cell, comprising: generating or procuring a plurality of expression vectors, each containing a different recombinant nucleic acid sequence that encodes a corresponding recombinant polypeptide; expressing the recombinant nucleic acid sequence in a plurality of host cells while culturing the host cells; sequencing the plurality of expression vectors after culturing the host cells; and correlating at least portions of the recombinant nucleic acid sequence with a toxicity measure.Type: ApplicationFiled: July 24, 2020Publication date: December 22, 2022Applicants: Nantomics, LLC, NantBio, Inc.Inventors: Kamil Wnuk, Lise Geissert, Jeremi Sudol, Charles Vaske, Stephen Charles Benz, Connie Tsai, Kayvan Niazi, Christopher W. Szeto
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Patent number: 11485957Abstract: Recombinant cells and methods therefor are contemplated that allow for rapid and high titer production of recombinant viruses, and especially replication deficient Ad5 virus. In some preferred aspects, the host cell is modified to produce an inhibitor that reduces or eliminates the expression of a therapeutic protein encoded in the virus, while in other aspects, the virus includes a gene that directly or indirectly reduces or eliminates the expression of a therapeutic protein encoded in the virus. Most preferably, shRNA encoded by the host cell will reduce or suppress expression of a payload gene encoded in the recombinant virus.Type: GrantFiled: October 9, 2018Date of Patent: November 1, 2022Assignee: NantBio, Inc.Inventors: Kayvan Niazi, Wael Tadros, Annie Shin
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Patent number: 11480572Abstract: Systems and methods for predicting an immune response against a tumor in a patient having the tumor are provided. The relative mass or changes of mass of tumor cells or immune cell in the tumor can be ex vivo observed, and an immune status of the tumor can be determined based on the mass of tumor cells or immune cell. The immune status can provide a guidance to predict the immune response against the tumor in the patient.Type: GrantFiled: December 17, 2017Date of Patent: October 25, 2022Assignees: NantBio, Inc., Nant Holdings IP, LLPInventors: Kayvan Niazi, Shahrooz Rabizadeh, Nicholas J. Witchey
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Publication number: 20220275098Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against CD30. Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals diagnosed with hematopoietic malignancies, including Hodgkin lymphoma, CD30-positive B cell lymphomas, CD30-positive T cell lymphomas, CD30-positive NK cell lymphomas.Type: ApplicationFiled: February 24, 2022Publication date: September 1, 2022Applicant: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Helty Adisetiyo, Hermes J. Garban, Mark Guido, Heather McFarlane, Tan Trinh, Shiho Tanaka
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Publication number: 20220235130Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.Type: ApplicationFiled: January 28, 2022Publication date: July 28, 2022Applicant: NantBio, Inc.Inventors: Clifford Anders Olson, Kayvan Niazi, Hermes J. Garban, Raymond Wong, Shiho Tanaka
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Patent number: 11364265Abstract: Systems and methods are presented that provide for improved NK cell function. In preferred aspects, NK-92 cells express recombinant er/LSP-IL-15 to so render the NK-92 cells independent of exogenous cytokines and to provide extracellular immune stimulation.Type: GrantFiled: February 27, 2020Date of Patent: June 21, 2022Assignees: NantCell, Inc., NantBio, Inc., ImmunityBio, Inc.Inventors: Patrick Soon-Shiong, Shahrooz Rabizadeh, Kayvan Niazi, Hans G. Klingemann